Project description
Streamlining the synthesis of complex and biologically active linked rings
The chemical formula of a molecule tells us a lot about its makeup – the number of atoms of each element present. However, many molecules can exist in more than one 3D form depending on which atoms are where. Enantiomers, molecules with the same chemical formula but whose 3D structures are mirror images of each other, are common and a thorn in the side of synthetic chemists. When it comes to biological activity, enantiomers can have different functions, or one can have no functional activity at all. The more complex the molecule, the more difficult it can be to control its final form. The EU-funded SmART project is developing the first-ever catalytic enantioselective reactions to produce complex linked rings employing one of the most widely used and important reagents, samarium(II) diiodide, significantly streamlining the synthesis of biologically active molecules.
Objective
Complex biologically-active molecules, containing linked rings of atoms and possessing elaborate 3D forms, represent the ultimate challenge for synthetic chemists. As many of society’s established and future drugs, agrochemicals, and biological probes, boast intricate architectures, the ability to efficiently generate molecular complexity from simple starting materials is vital. Radical cyclization cascade reactions could well provide the solution; they have the potential to deliver complex architectures, with control of three dimensional shape, in one-step. Unfortunately, carrying out reactions with radicals in an enantiocontrolled fashion remains challenging due to their high reactivity. This is particularly the case for radicals generated using the classical reagent, samarium(II) diiodide (SmI2). SmI2 is one of the global community’s most important and widely used reagents for radical chemistry, as evidenced by its commercial availability and its pivotal use in numerous scientific studies around the world. Despite over 40 years of widespread use, and 1000s of publications describing its chemistry, two well-known disadvantages shadow SmI2: 1. An inability to control the enantioselectivity of radical reactions using SmI2, and; 2. The requirement for the use of a significant stoichiometric excess of SmI2 thus raising issues of cost and waste. Bringing together the Procter group’s recent breakthroughs in chiral ligand control and catalysis using SmI2, Dr Agasti’s ‘SmART’ project will develop the first catalytic enantioselective reactions using SmI2. Furthermore, the new catalytic processes will be used to convert simple feedstocks into high-value, complex, cyclic molecules bearing multiple stereocenters with high enantio- and diastereocontrol. Previously, such molecules could only be prepared by laborious multi-step synthesis. Dr Agasti’s approach will therefore streamline complex molecule synthesis, saving time and money, and minimizing chemical waste.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
M13 9PL Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.