Insight into brain cortex dynamics
In the mammalian brain, sensory perception is achieved through a fine orchestration of neocortical networks, which are formed by a rich diversity of excitatory and inhibitory neurons. In particular, the neocortical layer 1 (L1) integrates motor cortex and thalamic inputs to facilitate top-down context-dependent sensory processing. The scope of the EU-funded InProSMod project is to delineate the role of L1 interneurons in decoding sensory information. Scientists will employ electrophysiology, imaging and theoretical modelling to investigate whisking in mice, a behaviour used for exploratory movements and spatial navigation. Apart from advancing our knowledge of cortical circuit dynamics, the project's work may have positive implications for several brain disorders.
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