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Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation

Project description

Insight into brain cortex dynamics

In the mammalian brain, sensory perception is achieved through a fine orchestration of neocortical networks, which are formed by a rich diversity of excitatory and inhibitory neurons. In particular, the neocortical layer 1 (L1) integrates motor cortex and thalamic inputs to facilitate top-down context-dependent sensory processing. The scope of the EU-funded InProSMod project is to delineate the role of L1 interneurons in decoding sensory information. Scientists will employ electrophysiology, imaging and theoretical modelling to investigate whisking in mice, a behaviour used for exploratory movements and spatial navigation. Apart from advancing our knowledge of cortical circuit dynamics, the project's work may have positive implications for several brain disorders.

Call for proposal

H2020-MSCA-IF-2019
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Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
Address
Boulevard De L'hopital 47
75013 Paris
France
Activity type
Research Organisations
EU contribution
€ 196 707,84