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Mitochondrial integrity and autoinflammation

Project description

Mitochondria in rare immune diseases

Interferons (IFNs) represent the first line of defence against viruses, and upregulation of IFN signalling is the hallmark of a rare genetic group of diseases known as type I interferonopathies (T1IFNs). Nucleic acid metabolism and mitochondria seem to trigger IFN signalling and may constitute new therapeutic targets for T1IFNs. The EU-funded MitoFeron project will focus on a mitochondrial protein involved in enhanced IFN signalling observed in T1IFN patients and investigate its role in organelle homeostasis and IFN induction. The results will lead to a new clinical screening protocol for T1IFN patients and new targets for therapeutic intervention.

Call for proposal

H2020-MSCA-IF-2019
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Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION
Address
24 Bd Du Montparnasse
75015 Paris 15
France
Activity type
Research Organisations
EU contribution
€ 184 707,84