Renal iron homeostasis tackles with glucose metabolism to confer disease tolerance in malaria infection

Project description

A novel approach for treating malaria

Ferroptosis is a newly discovered process of iron-dependent cell death that seems to be implicated in various diseases including malaria. Scientists of the EU-funded RIGM project are working under the hypothesis that the modulation of iron metabolism could serve as a novel therapeutic intervention against malaria. Research efforts will focus on the investigation of ferroptosis in the kidneys during malaria and its impact on glucose metabolism. Transcriptomic and metabolomic analyses in a mouse model of the disease are expected to unveil novel targets of ferroptosis manipulation and help scientists understand how iron metabolism affects organ homeostasis.

Fields of science

• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › basic medicine › physiology › homeostasis

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

FUNDACAO CALOUSTE GULBENKIAN

Net EU contribution

€ 147 815,04

Address

Avenida Berna 45
1000 Lisboa
Portugal

Region

Continente › Área Metropolitana de Lisboa › Área Metropolitana de Lisboa

Activity type

Research Organisations

Links

Non-EU contribution

€ 0,00