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Renal iron homeostasis tackles with glucose metabolism to confer disease tolerance in malaria infection

Project description

A novel approach for treating malaria

Ferroptosis is a newly discovered process of iron-dependent cell death that seems to be implicated in various diseases including malaria. Scientists of the EU-funded RIGM project are working under the hypothesis that the modulation of iron metabolism could serve as a novel therapeutic intervention against malaria. Research efforts will focus on the investigation of ferroptosis in the kidneys during malaria and its impact on glucose metabolism. Transcriptomic and metabolomic analyses in a mouse model of the disease are expected to unveil novel targets of ferroptosis manipulation and help scientists understand how iron metabolism affects organ homeostasis.

Coordinator

FUNDACAO CALOUSTE GULBENKIAN
Net EU contribution
€ 147 815,04
Address
Avenida Berna 45
1000 Lisboa
Portugal

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Non-EU contribution
€ 0,00