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Renal iron homeostasis tackles with glucose metabolism to confer disease tolerance in malaria infection

Project description

A novel approach for treating malaria

Ferroptosis is a newly discovered process of iron-dependent cell death that seems to be implicated in various diseases including malaria. Scientists of the EU-funded RIGM project are working under the hypothesis that the modulation of iron metabolism could serve as a novel therapeutic intervention against malaria. Research efforts will focus on the investigation of ferroptosis in the kidneys during malaria and its impact on glucose metabolism. Transcriptomic and metabolomic analyses in a mouse model of the disease are expected to unveil novel targets of ferroptosis manipulation and help scientists understand how iron metabolism affects organ homeostasis.


Net EU contribution
€ 147 815,04
Avenida Berna 45
1000 Lisboa

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Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Non-EU contribution
€ 0,00