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Antimicrobial resistance in engineered wastewater systems – Predicting the impacts of dynamic exposure levels to antimicrobial agents on AMR attenuation and amplification

Descripción del proyecto

Predecir la propagación de la resistencia microbiana en los sistemas de tratamiento de aguas residuales

La resistencia a los antimicrobianos (RAM) constituye un problema de salud creciente. La propagación de la RAM en el medio acuático supone una grave amenaza para el tratamiento de las aguas residuales (TMA) que se utiliza para hacer frente a la escasez de agua y alimentos. El objetivo del proyecto IDYEA, financiado con fondos europeos, es modelar de forma experimental la dinámica de la aparición y el destino de determinados antimicrobianos y desarrollar modelos de simulación para predecir la propagación de la RAM en diferentes etapas del TMA. El proyecto ayudará a desarrollar soluciones tecnoeconómicas para evaluar el riesgo de propagación de la RAM en los TMA y hacer sugerencias para un diseño óptimo y unos procesos de operación de reciclaje del agua seguro y sostenible.

Objetivo

Antimicrobial resistance (AMR) spread in the aquatic environment poses a growing public health risk with wastewater treatment (WWT), being the most important but still un-optimised barrier in confronting the global water and nutrient scarcity challenges.
Europe’s Water Framework Directive aims to achieve good qualitative and quantitative status of all water bodies. Challenges to the effective separation and recovery of water resources from hazardous materials, notably, antibiotic residues and AMR in WWT were recently identified.
In the past, AMR spread was experimentally assessed at static antimicrobial exposure levels that may suffer from lack of environmental representativeness as a result of significant variations in the emission of antimicrobials in urban catchments.
IDYEA takes on this challenge by (i) experimental modelling of dynamics in the occurrence and fate of selected antimicrobials; and (ii) developing dynamic simulation models for predicting AMR spread at different time scales in WWT.
The inter-sectorial and interdisciplinary IDYEA will be hosted at University of Bath, and supported by the Norwegian Institute for Water Research. It trains one experienced researcher in areas of process modelling, analytical chemistry, molecular microbiology and bioinformatics. IDYEA will offer excellent opportunities for mutual knowledge exchange and technology development.
IDYEA’s success is based on achieving the project objectives via seven work packages, including laboratory- and full-scale experimentation, model identification and risk assessment.
To provide techno-economic solutions to AMR risk assessment as well as optimised process design and operation, the expected main outcome comprises dynamic process rate and stoichiometric relations for AMR spread. IDYEA will disseminate results via public engagement, reaching out to especially young people, inspiring them to get involved with science to solve real-world problems, thus building our global water futures.

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.

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Coordinador

UNIVERSITY OF BATH
Aportación neta de la UEn
€ 224 933,76
Dirección
CLAVERTON DOWN
BA2 7AY Bath
Reino Unido

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Región
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 224 933,76