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Antimicrobial resistance in engineered wastewater systems – Predicting the impacts of dynamic exposure levels to antimicrobial agents on AMR attenuation and amplification

Descrizione del progetto

Prevedere la diffusione della resistenza agli antimicrobici nei sistemi di trattamento delle acque reflue

La resistenza agli antimicrobici (AMR, AntiMicrobial Resistance) è una crescente preoccupazione per la salute in tutto il mondo. La diffusione di una tale resistenza nell’ambiente acquatico rappresenta una grave minaccia al trattamento delle acque reflue (WWT, WasteWater Treatment) utilizzato per affrontare la scarsità di acqua e cibo. L’obiettivo del progetto IDYEA, finanziato dall’UE, è quello di modellare sperimentalmente la dinamica dell’occorrenza e del destino di antimicrobici selezionati e sviluppare modelli di simulazione per prevedere la diffusione dell’AMR in diverse fasi durante il WWT. Il progetto contribuirà a sviluppare soluzioni tecno-economiche per valutare il rischio di diffusione della resistenza agli antimicrobici nel WWT e a fornire suggerimenti per processi di progettazione e funzionamento ottimali per un riciclaggio dell’acqua sicuro e sostenibile.

Obiettivo

Antimicrobial resistance (AMR) spread in the aquatic environment poses a growing public health risk with wastewater treatment (WWT), being the most important but still un-optimised barrier in confronting the global water and nutrient scarcity challenges.
Europe’s Water Framework Directive aims to achieve good qualitative and quantitative status of all water bodies. Challenges to the effective separation and recovery of water resources from hazardous materials, notably, antibiotic residues and AMR in WWT were recently identified.
In the past, AMR spread was experimentally assessed at static antimicrobial exposure levels that may suffer from lack of environmental representativeness as a result of significant variations in the emission of antimicrobials in urban catchments.
IDYEA takes on this challenge by (i) experimental modelling of dynamics in the occurrence and fate of selected antimicrobials; and (ii) developing dynamic simulation models for predicting AMR spread at different time scales in WWT.
The inter-sectorial and interdisciplinary IDYEA will be hosted at University of Bath, and supported by the Norwegian Institute for Water Research. It trains one experienced researcher in areas of process modelling, analytical chemistry, molecular microbiology and bioinformatics. IDYEA will offer excellent opportunities for mutual knowledge exchange and technology development.
IDYEA’s success is based on achieving the project objectives via seven work packages, including laboratory- and full-scale experimentation, model identification and risk assessment.
To provide techno-economic solutions to AMR risk assessment as well as optimised process design and operation, the expected main outcome comprises dynamic process rate and stoichiometric relations for AMR spread. IDYEA will disseminate results via public engagement, reaching out to especially young people, inspiring them to get involved with science to solve real-world problems, thus building our global water futures.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Invito a presentare proposte

(si apre in una nuova finestra) H2020-MSCA-IF-2019

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Coordinatore

UNIVERSITY OF BATH
Contributo netto dell'UE
€ 224 933,76
Indirizzo
CLAVERTON DOWN
BA2 7AY BATH
Regno Unito
Regione
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 224 933,76