Dissecting TGF-β signalling in health and disease
Transforming growth factor beta (TGF-β) is a cytokine with multiple functions, encountered in different isoforms and expressed by various cell types. Deregulation of the TGF-β pathway is responsible for many human diseases including cancer, with recent evidence implicating TGF-β in the tumour microenvironment and in cancer immunotherapy. The aim of the EU-funded TGF-BTB project is to provide mechanistic insight into TGF-β signalling. For this purpose, scientists will combine structural and cell biology methods with in silico approaches and develop new tools to study the impact of pathway manipulation. Results will not only shed light on unexplored aspects of TGF-β signalling but also open new therapeutic avenues for treating diseases.
Fields of science
- natural sciencesbiological sciencescell biologycell signaling
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesdevelopmental biology
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicineimmunologyimmunotherapy
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF-GF - Global Fellowships
LS2 9JT Leeds
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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