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Chimeric antigen receptor (CAR) T-cell therapy against solid tumors by targeting the vasculature

Project description

Cell therapy targeting the tumour vasculature

Targeting the tumour vasculature is emerging as a promising anti-cancer treatment strategy. The scope of the EU-funded AngioCAR project is to develop an adoptive cell therapy based on chimeric antigen receptor (CAR) T cells directed against newly formed vessels in solid tumours. CAR T cells will carry antibodies against an extracellular form of the cytoskeletal protein vimentin encountered specifically in tumours. The vimentin-targeting CAR T cells will facilitate endothelial cell killing and also increase local inflammation, thereby reducing immune suppression. The AngioCAR approach alone or in combination with checkpoint inhibitors will open new possibilities for effective cancer therapy.

Objective

Advances of adoptive cellular therapy and monoclonal antibodies (mAbs) have resulted in unprecedented responses in patients with malignant tumors. Due to the fact that tumor growth and metastasis depend on the formation of new blood vessels, termed angiogenesis, direct targeting of the tumor vasculature provides a universal point of engagement in the battle against cancer. The main objective of this project is the development of chimeric antigen receptor (CAR) T cell approaches to target the tumor vasculature. Although extremely effective in hematological malignancies, success of CAR T cell strategies against solid tumors is lagging behind. It is hypothesized that aiming CAR T cells towards the tumor vasculature will be effective, as (i) the target is readily accessible via the blood stream and (ii) the engineered T cells do not need to enter the immunosuppressive environment of the tumor. Vimentin, which is known as a cytoskeletal protein, was found to massively externalize from tumor endothelial cells and to become deposited in the surrounding matrix, while expression in all other cells is exclusively intracellular. Therapeutic targeting of this extracellular vimentin (eVim) with antibodies – or through vaccination – resulted in pronounced inhibition of tumor growth, in absence of toxicity. AngioCAR is a multidisciplinary project, aimed to develop CAR T cells against eVim for targeting of solid tumors. Newly developed antibodies against eVim will be expressed as the CAR to redirect T cells to the tumor vasculature. This will not only result in direct endothelial cell killing, but will also increase local inflammation and reduce immune suppression. The project also aims for testing the possible synergistic combination with checkpoint inhibitors as well. AngioCAR results have the potential capacity to open new avenues in cancer treatment in terms of enhancing specificity and efficiency.

Coordinator

STICHTING AMSTERDAM UMC
Net EU contribution
€ 175 572,48
Address
DE BOELELAAN 1117
1081 HV Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Links
Total cost
€ 175 572,48