Cell therapy targeting the tumour vasculature
Targeting the tumour vasculature is emerging as a promising anti-cancer treatment strategy. The scope of the EU-funded AngioCAR project is to develop an adoptive cell therapy based on chimeric antigen receptor (CAR) T cells directed against newly formed vessels in solid tumours. CAR T cells will carry antibodies against an extracellular form of the cytoskeletal protein vimentin encountered specifically in tumours. The vimentin-targeting CAR T cells will facilitate endothelial cell killing and also increase local inflammation, thereby reducing immune suppression. The AngioCAR approach alone or in combination with checkpoint inhibitors will open new possibilities for effective cancer therapy.