Deciphering the role of PI(4,5)P2 and its modulators PPK-1 and CSNK-1 in nematode asymmetric division

Project description

Key determinants in asymmetric cell division

Early on during development cells undergo asymmetric divisions, giving rise to daughter cells of different fates. Despite the identification of specific factors that govern cell polarity and asymmetric division, there are certain aspects of the process that remain poorly understood. The EU-funded PIADINE project aims to investigate how plasma membrane tension affects cell division by focussing on the role of the lipid phosphatidylinositol biphosphate (PIP2). Using Caenorhabditis elegans and Pristionchus pacificus embryos as model organisms, researchers will provide novel insight into the mechanism of asymmetric cell division, with significant implications for developmental and stem cell biology.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › biological sciences › cell biology › cell polarity
• medical and health sciences › clinical medicine › embryology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Net EU contribution

€ 191 149,44

Address

Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland

Region

Schweiz/Suisse/Svizzera › Région lémanique › Vaud

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00