Key determinants in asymmetric cell division
Early on during development cells undergo asymmetric divisions, giving rise to daughter cells of different fates. Despite the identification of specific factors that govern cell polarity and asymmetric division, there are certain aspects of the process that remain poorly understood. The EU-funded PIADINE project aims to investigate how plasma membrane tension affects cell division by focussing on the role of the lipid phosphatidylinositol biphosphate (PIP2). Using Caenorhabditis elegans and Pristionchus pacificus embryos as model organisms, researchers will provide novel insight into the mechanism of asymmetric cell division, with significant implications for developmental and stem cell biology.
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