Gene network rewiring by an engineered CRIPSR-Cas12a variant

Project description

Large-scale gene editing

Recent years have witnessed the use of omics technologies to produce an unparalleled amount of information on cellular function, which, however, awaits experimental validation. The EU-funded GNRECC project builds on a previously developed CRISPR/12-based genome engineering tool capable of performing multiplex editing in dozens of endogenous genes simultaneously. In GNRECC, scientists plan to increase the efficiency of this molecular tool to rewire signalling pathways involved in cellular proliferation. For this purpose, they will design novel Cas12a protein variants, and using statistical physics alongside protein and genome engineering, they will build the foundation towards the large-scale engineering of gene networks.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › genetics › genomes

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

POLITECNICO DI TORINO

Net EU contribution

€ 171 473,28

Address

Corso Duca Degli Abruzzi 24
10129 Torino
Italy

Region

Nord-Ovest › Piemonte › Torino

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00