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Development of a connexon-proteoliposome delivery system to ameliorate inflammatory and mechanical stress responses in the regeneration of osteoarthritic cartilage

Project description

Intelligent cartilage scaffolds for osteoarthritis

Cartilage degenerative conditions such as osteoarthritis are treated using engineered scaffolds. However, to maximise the regenerative potential of these strategies, more specific cues are needed. The EU-funded ChondroCONNECT project will exploit connexins (Cx) in gap junctions as a mode of delivering small molecules with putative regenerative potential. The work will focus on Cx43, the most abundant form in cartilage and a therapeutic target for osteoarthritis. Scientists will investigate the role of Cx43 in osteoarthritis and develop a platform to knock down Cx43 and restore healthy metabolism. Through engineered Cx-containing proteoliposomes, ChondroCONNECT will improve existing strategies for cartilage repair in osteoarthritis.

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Net EU contribution
€ 196 590,72
Address
St Stephen's Green 123
2 Dublin
Ireland

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Region
Ireland Northern and Western Border
Activity type
Higher or Secondary Education Establishments
Other funding
€ 196 590,72