Development of a connexon-proteoliposome delivery system to ameliorate inflammatory and mechanical stress responses in the regeneration of osteoarthritic cartilage

Project description

Intelligent cartilage scaffolds for osteoarthritis

Cartilage degenerative conditions such as osteoarthritis are treated using engineered scaffolds. However, to maximise the regenerative potential of these strategies, more specific cues are needed. The EU-funded ChondroCONNECT project will exploit connexins (Cx) in gap junctions as a mode of delivering small molecules with putative regenerative potential. The work will focus on Cx43, the most abundant form in cartilage and a therapeutic target for osteoarthritis. Scientists will investigate the role of Cx43 in osteoarthritis and develop a platform to knock down Cx43 and restore healthy metabolism. Through engineered Cx-containing proteoliposomes, ChondroCONNECT will improve existing strategies for cartilage repair in osteoarthritis.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › genetics › RNA

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND

Net EU contribution

€ 196 590,72

Address

St Stephen's Green 123
2 Dublin
Ireland

Region

Ireland › Northern and Western › Border

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 196 590,72