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Mechanisms linking stress and ageing in two avian species exhibiting contrasted natural resistance to stress (NAtural REsistance to Stress-Induced Cellular Ageing)

Projektbeschreibung

Der Faktor Stress bei der Zellalterung

Die Zellalterung ist ein Prozess, der nach wie vor viele Rätsel aufgibt und in vielen Aspekten noch nicht ausreichend erforscht ist. Das EU-finanzierte Projekt NARESICA verfolgt deshalb das Ziel, die Rolle von Stress beim Alterungsprozess zu untersuchen. Anhand der Telomerlänge als Biomarker der Alterung werden die Forschenden der Frage nachgehen, wie chronischer Stress, und insbesondere das Stresshormon Glukokortikoid, die Alterung bei zwei Vogelarten beschleunigt. Ein besonderer Schwerpunkt wird dabei auf verschiedenen potenziellen Alterungsbeschleunigern wie mitochondrialen Funktionen, oxidativem Stress, DNS-Schäden und mTOR-Zellsignalwegen liegen. Insgesamt werden die Projektergebnisse wichtige Erkenntnisse über diesen grundlegenden biologischen Prozess und seine klinischen Implikationen liefern.

Ziel

Previous research has identified stress exposure as a key factor influencing health state and ageing rate. The overall aim of the proposed project is to investigate the precise mechanisms linking stress exposure to accelerated cellular ageing (using telomere length as a biomarker of ageing), and to identify potential mechanisms allowing some species to better prevent stress-induced ageing than others. To this aim I will use two avian species (Japanese quail and king penguin) to investigate (1) if chronic stress affects telomere shortening differently between species exhibiting contrasted stress resistance, (2) if glucocorticoid ‘stress’ hormones are directly responsible of the stress-induced alterations in telomere dynamics, (3) by which mechanisms (i.e. alterations of mitochondrial function, oxidative stress and DNA damage, impaired mTOR cellular signalling or telomere maintenance) stress exposure is accelerating telomere shortening, and if king penguin have specific mechanisms preventing/limiting stress-induced telomere shortening, and (4) if chronic stress / glucocorticoid hormones modify the acute oxidative stress responses of individuals. To this end, I will employ experimental approaches manipulating stress exposure and glucocorticoid hormones in captive Japanese quail and wild king penguins, and measure the resulting impact on telomere shortening and its potential cellular drivers (mitochondrial function, oxidative stress, mTOR cellular signalling). This project will enable a two-way transfer of skills and competences between the applicant and the host, by providing training to the applicant regarding mitochondrial biology, cellular signalling and gene expression, and by providing the host with the opportunity to integrate an ageing component through the use of telomeres in his current and future projects.

Koordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Netto-EU-Beitrag
€ 184 707,84
Adresse
Boulevard du 11 novembre 1918 num43
69622 Villeurbanne cedex
Frankreich

Auf der Karte ansehen

Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Weitere Finanzmittel
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