Identifying neuronal or muscle cell-specific suppressors that rescue motility defects in the ALS model of the nematode worm Caenorhabditis elegans

Projektinformationen

RescueMoDe

ID Finanzhilfevereinbarung: 895529

DOI

10.3030/895529

Projekt abgeschlossen

EK-Unterschriftsdatum 23 April 2020

Startdatum 2 August 2021

Enddatum 27 November 2023

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 175 572,48

EU-Beitrag

€ 175 572,48

Koordiniert durch

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

Periodic Reporting for period 1 - RescueMoDe (Identifying neuronal or muscle cell-specific suppressors that rescue motility defects in the ALS model of the nematode worm Caenorhabditis elegans)

Berichtszeitraum: 2021-08-02 bis 2023-08-01

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

I pursued a project to understand the mechanism behind a modifier of proteotoxicity using the nematode worm Caenorhabditis elegans. This modifier induces a protective effect in several worm models of ageing and neurodegeneration by extending lifespan and health span, indicating that it has a broadly neuroprotective effect. Understanding how it protects neurons can potentially lead to the development of new therapeutic strategies against ageing and neurodegenerative diseases.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

Using novel genetic tools, I identified that this modifier of proteotoxicity improved the health of some types of neurons during ageing, while other types of neurons are less affected. I also optimised a genetic tool that enables rapid depletion of a protein of interest in C. elegans worms. Therefore we are now able to deplete this modifier in any tissue of interest and at any timepoint. Using this optimised tool, we plan to investigate the mechanism of this modifier of toxicity further in several C. elegans models of neurodegeneration.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

My data implicates that this modifier of neurodegeneration is working on specific neuronal tissues. Further research is required to understand the exact neuroprotective effect of mechanism, but understanding the tissue localisation of these mechanisms in the future will help researchers develop targeted therapeutic strategies for ageing and neurodegenerative diseases.

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