Descripción del proyecto
Nuevos materiales para la diferenciación de células madre
Las células madre desempeñan un papel fundamental en la ingeniería de tejidos, dado que pueden utilizarse en tratamientos regeneradores, en implantes biomiméticos o para formar plataformas «in vitro» para el descubrimiento de fármacos. Se espera que los avances recientes en materiales biocompatibles tridimensionales revolucionen la ingeniería biomédica. El proyecto financiado con fondos europeos MultiStem aprovechará nuevos biomateriales óptica y eléctricamente activos para generar matrices tridimensionales multifuncionales a fin de controlar las células madre. La idea es investigar las señales eléctricas y ópticas que influyen sobre la diferenciación de las células madre y comprender cómo pueden emplearse estos materiales para aplicaciones biológicas. Se espera que los resultados del proyecto hagan avanzar la investigación sobre células madre hacia la consecución de objetivos terapéuticos y que mejoren de forma radical los dispositivos bioelectrónicos ya existentes.
Objetivo
The field of bioelectronics devices that can translate ionic signals in our bodies into electronic signals, is one of the most remarkable success stories of science and engineering over the last decades. Although such devices have been lifesavers (i.e. pacemakers, glucose meters), recent discoveries are about to change the entire pharmaceutical industry. Organic bioelectronics, devices based on biocompatible polymers, opening new horizons in biomedical engineering. Recent developments in 3D materials and devices show a tremendous potential to deliver human-like platforms for tissue growth, however, these devices are still in their infancy. This project aims to take a fundamental approach to designing composite materials with electrical and optical properties that may be used for a multitude of applications in biomedical engineering. The project proposes the realization of 3D multifunctional scaffolds for stem cell control by blending optically and electrically active biocompatible polymers. Beginning with films, to understand mixing and properties, the project will gain insight into how these materials may be used for biological applications. Subsequently, the materials will be prepared in 3D formats and used to host stem cells. The multifunctional properties of the proposed scaffolds will be used to determine the effect of electrical and optical cues on stem cell differentiation. Stem cells play a key role in tissue engineering medicine as they have already proven effective in developing new treatments. These highly biomimetic platforms and the fundamental knowledge produced in this project will be an invaluable tool to further progress with stem cell research towards therapeutic goals. As such, the outcomes of this proposal can, in the short term, benefit the field of organic bioelectronics by providing fundamental knowledge and a novel platform for a facile control of cell function and in the long term, can impact the global need for better treatment of diseases.
Ámbito científico
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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
CB2 1TN Cambridge
Reino Unido