Mechanoresponsive transcription factor in intestinal tissue repair
Inflammatory bowel disease (IBD), namely ulcerative colitis and Crohn’s disease, involves chronic pathologies of the intestines that affect millions of people. Currently, no curative therapies are available, and standard of care is limited to palliative treatments. Improving epithelial regeneration is likely to accelerate recovery and minimise exposure to luminal microbes, preventing inflammation and chronic damage. Recently, the mechanoresponsive transcription factor YAP has been identified as a key mediator of epithelial repair in IBD and is regulated by extracellular matrix rigidity, strain, shear stress and other processes linked to cytoskeletal integrity. The EU-funded InterYAP project proposes to carry out a proteomic study to dissect the mechanisms by which YAP is activated and exerts its functions in intestinal tissue repair.
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