Skip to main content

Super-enhancer modules controlling plasticity and response to therapy in pancreatic cancer

Project description

Pancreatic cancer characterisation at the single-cell level

Pancreatic ductal adenocarcinoma (PDAC) remains a cancer with dismal prognosis. However, recent evidence indicates that stratification into different subtypes provides a better guide for treatment decision. Despite patient heterogeneity and a lack of robust data, certain transcription factors are believed to act as drivers for these subtypes, and changes in their expression may even facilitate subtype switching. The EU-funded PDASwITch project will explore the role of the tumour microenvironment in this phenomenon. Using powerful high throughput single-cell profiling technologies, scientists will characterise the dynamic crosstalk between cancer cells and how this affects their phenotype. The ultimate goal is to clinically convert non-responder to responder tumours and improve patient outcome.

Coordinator

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Net EU contribution
€ 160 932,48
Address
C Melchor Fernandez Almagro 3
28029 Madrid
Spain

See on map

Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 0,00