Project description
Pancreatic cancer characterisation at the single-cell level
Pancreatic ductal adenocarcinoma (PDAC) remains a cancer with dismal prognosis. However, recent evidence indicates that stratification into different subtypes provides a better guide for treatment decision. Despite patient heterogeneity and a lack of robust data, certain transcription factors are believed to act as drivers for these subtypes, and changes in their expression may even facilitate subtype switching. The EU-funded PDASwITch project will explore the role of the tumour microenvironment in this phenomenon. Using powerful high throughput single-cell profiling technologies, scientists will characterise the dynamic crosstalk between cancer cells and how this affects their phenotype. The ultimate goal is to clinically convert non-responder to responder tumours and improve patient outcome.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF-EF-ST - Standard EFCoordinator
28029 Madrid
Spain
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