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Characterize corpus callosum-mediated local and global inhibitory effects with novel MRI-compatible photonic crystal fiber-based multifunction probe and wireless amplified NMR detector in rat brain

Project description

Untangling the functional and neuronal interconnections between right and left hemispheres

The corpus callosum is a c-shaped structure under the cortex consisting of about 200 million axons that interconnect the left and right hemispheres. It integrates sensory, motor and cognitive signals from the two sides, and disruption of this connection has been linked to numerous diseases and disorders. However, the neural substrates of the clinical manifestations are largely unknown. The ambitious EU-funded CCMuPWA project is developing highly sensitive techniques to find answers. Scientists are stimulating the corpus callosum in behaving rats while utilising enhanced multimodal functional magnetic resonance imaging (fMRI) and calcium recording to characterise brain activity, including the calcium dynamics of astrocytes. Outcomes should yield a holistic picture of neuroglial interactions in the corpus callosum of normal and diseased brains.

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Net EU contribution
€ 205 352,64
Address
Hofgartenstrasse 8
80539 Munchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MICHIGAN STATE UNIVERSITY
United States
Net EU contribution
€ 0,00
Address
Administration Building 360
48824 East Lansing, Michigan

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 123 949,44