Project description
The role of dietary fibre in intestinal homeostasis
Microscopic colitis (MC) is a chronic disease associated with mild intestinal inflammation. Considering the increase in inflammatory bowel disease incidence and the potential of intestinal inflammation to cause peripheral inflammation and metabolic disease, there is a pressing need to understand its underlying mechanisms. To address this, scientists of the EU-funded FIBCOLIT project will investigate the impact of fermentable dietary fibres (DFs) on intestinal physiology and inflammation. Through an intervention study on MC patients, the project will follow a multi-omics approach to examine DF-induced changes in inflammatory markers, intestinal microbiota and well-being. The link between DF and intestinal homeostasis may introduce a non-pharmaceutical option to prevent and manage inflammatory diseases of the intestine.
Objective
The FIBCOLIT project investigates the impact of fermentable dietary fibres (DFs) on intestinal physiology and inflammation via dietary intervention study in human patients with microscopic colitis (MC), a chronic disease characterised by sustained mild intestinal inflammation. This subject topic has significant interest for public health considering 1) the increased global incidence and prevalence of inflammatory bowel diseases in the last 20 years, and 2) the increased scientific knowledge regarding the role of intestinal inflammation in driving the development of systemic inflammation in metabolic diseases. Currently, considerable knowledge gaps exists regarding the biological and physiological mechanisms that maintain and modulate intestinal homeostasis as well as the pathophysiological mechanisms that lead to chronic intestinal inflammation. The FIBCOLIT project aims to answer these open scientific questions through a multi-omics approach employing several analytical methods to examine DF-induced changes in intestinal barrier function, inflammatory markers, intestinal microbiota composition and functionality, as well as gastrointestinal symptoms, quality of life, and general well-being. The projects utilises a DF known to promote the production of luminal butyrate, a short-chain fatty acid that has been associated with several positive health effects. Overall, the project's methodology allows specific targeting of the mechanistic links between DF intake, butyrate, and intestinal health. Should DF supplementation prove effective at restoring intestinal homeostasis, it could potentially offer a non-pharmaceutical option to the prevention and management of diseases characterised by chronic intestinal inflammation. The project results could potentially also serve as starting point in the development of functional foods for the general public.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
70182 Orebro
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.