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Delineating epigenome regulators as functional survival dependencies in intrahepatic cholangiocarcinoma.

Project description

Epigenome regulators in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (iCC) is an aggressive cancer of the biliary tract with patient survival less than one year after diagnosis. Genomic analyses have identified mutations in epigenetic regulators associated with iCC. The EU-funded EPiCC project proposes to use patient-derived cell lines to characterise the functional role of key epigenetic regulators and the modifications linked to iCC chemotherapy resistance to identify new therapeutic targets. The specific aims of the project are the identification of iCC-associated functional epigenetic modifications using CRISPR/Cas9 technology and the characterisation of the epigenomic changes induced by the loss of the epigenetic regulators.


Net EU contribution
€ 207 312,00
Norregade 10
1165 Kobenhavn

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Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00