Delineating epigenome regulators as functional survival dependencies in intrahepatic cholangiocarcinoma.

Project description

Epigenome regulators in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (iCC) is an aggressive cancer of the biliary tract with patient survival less than one year after diagnosis. Genomic analyses have identified mutations in epigenetic regulators associated with iCC. The EU-funded EPiCC project proposes to use patient-derived cell lines to characterise the functional role of key epigenetic regulators and the modifications linked to iCC chemotherapy resistance to identify new therapeutic targets. The specific aims of the project are the identification of iCC-associated functional epigenetic modifications using CRISPR/Cas9 technology and the characterisation of the epigenomic changes induced by the loss of the epigenetic regulators.

Fields of science

• natural sciences › biological sciences › genetics › mutation
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › health sciences › personalized medicine
• medical and health sciences › basic medicine › physiology › homeostasis
• natural sciences › biological sciences › genetics › epigenetics

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinator

KOBENHAVNS UNIVERSITET

Net EU contribution

€ 207 312,00

Address

Norregade 10
1165 Kobenhavn
Denmark

Region

Danmark › Hovedstaden › Byen København

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00