Epigenome regulators in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCC) is an aggressive cancer of the biliary tract with patient survival less than one year after diagnosis. Genomic analyses have identified mutations in epigenetic regulators associated with iCC. The EU-funded EPiCC project proposes to use patient-derived cell lines to characterise the functional role of key epigenetic regulators and the modifications linked to iCC chemotherapy resistance to identify new therapeutic targets. The specific aims of the project are the identification of iCC-associated functional epigenetic modifications using CRISPR/Cas9 technology and the characterisation of the epigenomic changes induced by the loss of the epigenetic regulators.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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