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NUCLEAR DYNAMICS OF AUTOPHAGY IN PLANT IMMUNITY

Project description

Connecting the nucleus and autophagy in plant defence

Autophagy is a major renewal mechanism of the cell that removes damaged or redundant cellular components in eukaryotes. It is a defensive mechanism of plants against pathogens and could open new paths to improving disease resistance in crops. Research on plant autophagy initially emphasised cytoplasmic mechanisms and targets. However, the degradation of nuclear components and the epigenetic regulation of autophagy have recently attracted increasing attention in yeast and mammalian systems. The EU-funded NUCLAGY project is based on the researcher’s findings that several isoforms of the Arabidopsis core autophagy protein 8 (ATG8) localise to distinct nuclear components. The project will identify nuclear ATG8 interactomes in physiological and disease conditions by affinity-immunoprecipitation and mass spectrometry analysis. The characterisation of interactors is expected to uncover novel regulators and nuclear targets of autophagy with implications for plant defence and crop improvement.

Call for proposal

H2020-MSCA-IF-2019
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Coordinator

SVERIGES LANTBRUKSUNIVERSITET
Address
Almas Alle 8
750 07 Uppsala
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 203 852,16