NUCLEAR DYNAMICS OF AUTOPHAGY IN PLANT IMMUNITY

Project description

Connecting the nucleus and autophagy in plant defence

Autophagy is a major renewal mechanism of the cell that removes damaged or redundant cellular components in eukaryotes. It is a defensive mechanism of plants against pathogens and could open new paths to improving disease resistance in crops. Research on plant autophagy initially emphasised cytoplasmic mechanisms and targets. However, the degradation of nuclear components and the epigenetic regulation of autophagy have recently attracted increasing attention in yeast and mammalian systems. The EU-funded NUCLAGY project is based on the researcher’s findings that several isoforms of the Arabidopsis core autophagy protein 8 (ATG8) localise to distinct nuclear components. The project will identify nuclear ATG8 interactomes in physiological and disease conditions by affinity-immunoprecipitation and mass spectrometry analysis. The characterisation of interactors is expected to uncover novel regulators and nuclear targets of autophagy with implications for plant defence and crop improvement.

Fields of science

• natural sciences › biological sciences › microbiology › virology
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry
• agricultural sciences › agriculture, forestry, and fisheries › agriculture
• natural sciences › biological sciences › genetics and heredity › epigenetics

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

SVERIGES LANTBRUKSUNIVERSITET

Address

Almas Alle 8
750 07 Uppsala
Sweden

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 203 852,16