Project description
New instrumentation for sequencing of HS structures
Heparan sulphate (HS) is a polysaccharide found in animal tissues. HS binds a variety of protein ligands and regulates a range of biological activities, including development, angiogenesis, blood coagulation and tumour metastasis. The EU-funded HS-SEQ project aims to address a lack of methods for the sequencing of HS structures by developing a new instrumentation that can simultaneously record multiple molecular properties such as molecular weight by mass spectrometry, collisional cross sections by ion mobility spectroscopy and vibrational properties by gas-phase infrared ion spectroscopy. Applications of the new technology will enable the identification of HS codes that promote the generation of dopaminergic neurons from human pluripotent stem cells for cell replacement therapy in Parkinson’s disease.
Fields of science
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicineneurologyparkinson
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
- natural sciencesphysical sciencesopticsspectroscopy
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
3584 CS Utrecht
Netherlands
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Participants (8)
1165 Kobenhavn
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17177 Stockholm
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Participation ended
6525 XZ Nijmegen
14195 Berlin
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SK9 4AX Wilmslow Cheshire
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41043 Formigine
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L69 7ZB Liverpool
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6525 GA Nijmegen
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