Project description
New instrumentation for sequencing of HS structures
Heparan sulphate (HS) is a polysaccharide found in animal tissues. HS binds a variety of protein ligands and regulates a range of biological activities, including development, angiogenesis, blood coagulation and tumour metastasis. The EU-funded HS-SEQ project aims to address a lack of methods for the sequencing of HS structures by developing a new instrumentation that can simultaneously record multiple molecular properties such as molecular weight by mass spectrometry, collisional cross sections by ion mobility spectroscopy and vibrational properties by gas-phase infrared ion spectroscopy. Applications of the new technology will enable the identification of HS codes that promote the generation of dopaminergic neurons from human pluripotent stem cells for cell replacement therapy in Parkinson’s disease.
Fields of science
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicineneurologyparkinson
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
- natural sciencesphysical sciencesopticsspectroscopy
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
3584 CS Utrecht
Netherlands
See on map
Participants (8)
1165 Kobenhavn
See on map
17177 Stockholm
See on map
Participation ended
6525 XZ Nijmegen
14195 Berlin
See on map
SK9 4AX Wilmslow Cheshire
See on map
41043 Formigine
See on map
L69 7ZB Liverpool
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6525 GA Nijmegen
See on map