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HEPARIN AND HEPARAN SULPHATE: FROM SEQUENCE DETERMINATION TO THERAPEUTIC STRATEGIES FOR PARKINSON’S DISEASE

Project description

New instrumentation for sequencing of HS structures

Heparan sulphate (HS) is a polysaccharide found in animal tissues. HS binds a variety of protein ligands and regulates a range of biological activities, including development, angiogenesis, blood coagulation and tumour metastasis. The EU-funded HS-SEQ project aims to address a lack of methods for the sequencing of HS structures by developing a new instrumentation that can simultaneously record multiple molecular properties such as molecular weight by mass spectrometry, collisional cross sections by ion mobility spectroscopy and vibrational properties by gas-phase infrared ion spectroscopy. Applications of the new technology will enable the identification of HS codes that promote the generation of dopaminergic neurons from human pluripotent stem cells for cell replacement therapy in Parkinson’s disease.

Call for proposal

H2020-FETOPEN-2018-2020

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Sub call

H2020-FETOPEN-2018-2019-2020-01

Coordinator

UNIVERSITEIT UTRECHT
Net EU contribution
€ 864 400,00
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (8)

KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 664 360,00
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 717 500,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 14 047,50
Address
Houtlaan 4
6525 XZ Nijmegen
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FREIE UNIVERSITAET BERLIN
Germany
Net EU contribution
€ 883 750,00
Address
Kaiserswerther Strasse 16-18
14195 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MICROMASS UK LTD
United Kingdom
Net EU contribution
€ 12 500,00
Address
Waters Wilmslow Stamford Avenue Altrincham Road
SK9 4AX Wilmslow Cheshire

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Region
North West (England) Cheshire Cheshire East
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 75 000,00
OPOCRIN SPA
Italy
Net EU contribution
€ 12 500,00
Address
Via Pacinotti 3
41043 Formigine

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Region
Nord-Est Emilia-Romagna Modena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 75 000,00
INTELLIHEP LTD
United Kingdom
Net EU contribution
€ 101 500,00
Address
Crown Street Merseybio
L69 7ZB Liverpool

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
North West (England) Merseyside Liverpool
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 577 827,50
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00