HEPARIN AND HEPARAN SULPHATE: FROM SEQUENCE DETERMINATION TO THERAPEUTIC STRATEGIES FOR PARKINSON’S DISEASE

Project Information

HS-SEQ

Grant agreement ID: 899687

DOI

10.3030/899687

Project closed

EC signature date 28 May 2020

Start date 1 October 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 998 385,00

EU contribution

€ 3 848 385,00

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (4)

Prototype MS-IMS-IR instrument based on Waters SYNAPT G2S

Prototype MSIMSIR instrument based on Waters SYNAPT G2S

Automation platform for chemoenzymatic synthesis of HS saccharide standards
Advanced separations methods for natural heparin and HS
Workflows for phage-display antibodies development using synthetic and cellular HS

Workflows for phagedisplay antibodies development using synthetic and cellular HS

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (1)

Public website

Publications

Peer reviewed articles (16)

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Author(s): Pantazis C.B., Yang A., Lara E., McDonough J.A., Blauwendraat C., Peng L., Oguro H., Kanaujiya J., Zou J., Sebesta D., Pratt G., Cross E., Blockwick J., Buxton P., Kinner-Bibeau L., Medura C., Tompkins C., Hughes S., Santiana M., Faghri F., Nalls M.A., Vitale D., Ballard S., Qi Y.A., Ramos D.M., Anderson K.M., Stadler J., Narayan P., Papademetriou J., Reilly L., Nelson M.P., Aggarwal S., Rosen L.U
Published in: Cell Stem Cell, 2022, Page(s) 1685-1702 e22, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.11.004

Heparin increases the antibiotic efficacy of colistin

Author(s): Szekeres G.P., Hanozin E., Diehn R., Horlebein J., Polewski L., Zappe A., Lauster D., Pagel K.
Published in: Frontiers in Analytical Science, 2023, ISSN 2673-9283
Publisher: Frontiers
DOI: 10.3389/frans.2023.1154391

Chondroitin Sulfate Disaccharides in the Gas Phase: Differentiation and Conformational Constraints

Author(s): Maike Lettow, Kim Greis, Márkó Grabarics, Jan Horlebein, Rebecca L. Miller, Gerard Meijer, Gert von Helden, Kevin Pagel
Published in: The Journal of Physical Chemistry A, Issue 125/20, 2021, Page(s) 4373-4379, ISSN 1089-5639
Publisher: American Chemical Society
DOI: 10.1021/acs.jpca.1c02463

Identification of heparin-binding amino acid residues in antibody HS4C3 with the potential to design antibodies against heparan sulfate domains

Author(s): Lars A A Damen, Thao P Bui, Thierry van Wessel, Yong Li, Bart F Straten, Robin Pampiermole, Willeke F Daamen, David G Fernig, Toin H van Kuppevelt
Published in: Glycobiology, Issue 34, 2024, ISSN 1460-2423
Publisher: Oxford University Press (OUP)
DOI: 10.1093/glycob/cwae046

Ion Mobility Mass Spectrometry‐Based Disaccharide Analysis of Glycosaminoglycans

Author(s): Lukasz Polewski, Eunjin Moon, Andreas Zappe, Michael Götze, Gergo Peter Szekeres, Christian Roth, Kevin Pagel
Published in: Chemistry – A European Journal, Issue 30, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202400783

Predicting structural motifs of glycosaminoglycans using cryogenic infrared spectroscopy and random forest

Author(s): Riedel J., Lettow M., Grabarics M., Gotze M., Miller R.L., Boons G.J., Meijer G., von Helden G., Szekeres G.P., Pagel K.
Published in: J. Am. Chem. Soc., 2023, Page(s) 7859-7868, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c12762

Chemokine Oligomers and the Impact of Fondaparinux Binding

Author(s): Gergo Peter Szekeres, Douglas P. Dyer, Rebecca L. Miller, Kevin Pagel
Published in: Journal of the American Society for Mass Spectrometry, Issue 35, 2024, Page(s) 1550-1555, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.4c00142

Analytical challenges of glycosaminoglycans at biological interfaces

Author(s): Gergo Peter Szekeres, Kevin Pagel, Zsuzsanna Heiner
Published in: Analytical and Bioanalytical Chemistry, 2021, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-021-03705-w

Ion mobility-tandem mass spectrometry of mucin-type O-glycans

Author(s): Leïla Bechtella, Jin Chunsheng, Kerstin Fentker, Güney R. Ertürk, Marc Safferthal, Łukasz Polewski, Michael Götze, Simon Y. Graeber, Gaël M. Vos, Weston B. Struwe, Marcus A. Mall, Philipp Mertins, Niclas G. Karlsson, Kevin Pagel
Published in: Nature Communications, Issue 15, 2024, Page(s) 1-10, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46825-4

Mass Spectrometry-Based Techniques to Elucidate the Sugar Code

Author(s): Márkó Grabarics, Maike Lettow, Carla Kirschbaum, Kim Greis, Christian Manz, Kevin Pagel
Published in: Chemical Reviews, 2021, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00380

The interaction of chondroitin sulfate with a lipid monolayer observed by using nonlinear vibrational spectroscopy

Author(s): Gergo Peter Szekeres, Szilvia Krekic, Rebecca L. Miller, Mark Mero, Kevin Pagel, Zsuzsanna Heiner
Published in: Physical Chemistry Chemical Physics, Issue 23/23, 2021, Page(s) 13389-13395, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cp01975a

Well-defined heparin mimetics can inhibit binding of the trimeric spike of SARS—COV2 in a length-dependent manner

Author(s): Sun L., Chopra P., Tomris I., van der Woude R., Liu L., de Vries R.P., Boons G.J.
Published in: JACS Au, 2023, Page(s) 1185-1195, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00042

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors

Author(s): Gray A.L., Karlsson R., Roberts A.R.E., Ridley A.J.L., Pun N., Khan B., Lawless C., Luis R., Szpakowska M., Chevigne A., Hughes C.E., Medina-Ruiz L., Birchenough H.L., Mulholland I.Z., Salanga C.L., Yates E.A., Turnbull J.E., Handel T.M., Graham G.J., Jowitt T.A., Schiessl I., Richter R.P., Miller R.L., Dyer D.P.
Published in: Cell Rep, 2023, Page(s) 111930, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111930

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides having a Domain Structure**

Author(s): Sun, Lifeng; Chopra, Pradeep; Boons, Geert-Jan; Afd Chemical Biology and Drug Discovery; Sub Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery
Published in: Angewandte Chemie-International Edition, 2022, Page(s) e202211112, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202211112

State‐of‐the‐art glycosaminoglycan characterization

Author(s): Andreas Zappe, Rebecca L. Miller, Weston B. Struwe, Kevin Pagel
Published in: Mass Spectrometry Reviews, 2021, ISSN 0277-7037
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mas.21737

Protein Secondary Structure Affects Glycan Clustering in Native Mass Spectrometry

Author(s): Hao Yan, Julia Lockhauserbäumer, Gergo Peter Szekeres, Alvaro Mallagaray, Robert Creutznacher, Stefan Taube, Thomas Peters, Kevin Pagel, Charlotte Uetrecht
Published in: Life, Issue 11/6, 2021, Page(s) 554, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11060554