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AI-enabled RNA nanotechnology DElivery SysTem for INformATION transfer into cells.

Project description

Intelligent RNA-based delivery of new information into live cells

The EU-funded DESTINATION project aims to create a first-generation RNA-based delivery platform (RNano) for effective delivery of information (mRNA) into cells in vivo. Addressing this challenging goal requires a novel, biocompatible and scalable system to protect the deliverable mRNA from degradation in blood, escape the immune response, and provide high selectivity in cell targeting. The consortium will use AI/machine learning to generate a library of programmable RNano scaffolds for packaged mRNA and RNA aptamers for laser-specific internalisation of RNanos into cells. DESTINATION success could enable novel functions such as the production of a cell's own medicine by replacing the faulty mRNA or engineering cells to fight genetic disorders and cancer.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Coordinator

SIXFOLD BIOSCIENCE LTD
Address
The Imperial College White City Inc Innovation Hub
W12 0BZ London
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 886 250

Participants (6)

EXPLORA SRL
Italy
EU contribution
€ 492 473,75
Address
Via Giacomo Peroni 386
00131 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 509 183,75
Address
Avenida De Pio Xii 55
31008 Pamplona
Activity type
Research Organisations
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 572 336,25
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 306 750
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
FUTURESYNTHESIS SP ZOO
Poland
EU contribution
€ 222 125
Address
Rubiez, Nr 46, Lok. B
61612 Poznan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 392 770
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments