AI-enabled RNA nanotechnology DElivery SysTem for INformATION transfer into cells.

Project description

Intelligent RNA-based delivery of new information into live cells

The EU-funded DESTINATION project aims to create a first-generation RNA-based delivery platform (RNano) for effective delivery of information (mRNA) into cells in vivo. Addressing this challenging goal requires a novel, biocompatible and scalable system to protect the deliverable mRNA from degradation in blood, escape the immune response, and provide high selectivity in cell targeting. The consortium will use AI/machine learning to generate a library of programmable RNano scaffolds for packaged mRNA and RNA aptamers for laser-specific internalisation of RNanos into cells. DESTINATION success could enable novel functions such as the production of a cell's own medicine by replacing the faulty mRNA or engineering cells to fight genetic disorders and cancer.

Fields of science

• natural sciences › biological sciences › genetics › RNA
• medical and health sciences › basic medicine › immunology
• medical and health sciences › health sciences › infectious diseases
• medical and health sciences › clinical medicine › oncology
• engineering and technology › nanotechnology

Programme(s)

• H2020-EU.1.2.1. - FET Open

Topic(s)

• FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

SIXFOLD BIOSCIENCE LTD

Address

The Imperial College White City Inc Innovation Hub
W12 0BZ London
United Kingdom

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU contribution

€ 886 250

Participants (6)

EXPLORA SRL

Italy

EU contribution

€ 492 473,75

Address

Via Giacomo Peroni 386
00131 Roma

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA

Spain

EU contribution

€ 509 183,75

Address

Avenida De Pio Xii 55
31008 Pamplona

Activity type

Research Organisations

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU contribution

€ 572 336,25

Address

Kings Gate
NE1 7RU Newcastle Upon Tyne

Activity type

Higher or Secondary Education Establishments

TECHNISCHE UNIVERSITEIT EINDHOVEN

Netherlands

EU contribution

€ 306 750

Address

Groene Loper 3
5612 AE Eindhoven

Activity type

Higher or Secondary Education Establishments

FUTURESYNTHESIS SP ZOO

Poland

EU contribution

€ 222 125

Address

Rubiez, Nr 46, Lok. B
61612 Poznan

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN

Germany

EU contribution

€ 392 770

Address

Regina Pacis Weg 3
53113 Bonn

Activity type

Higher or Secondary Education Establishments