Project description
Intelligent RNA-based delivery of new information into live cells
The EU-funded DESTINATION project aims to create a first-generation RNA-based delivery platform (RNano) for effective delivery of information (mRNA) into cells in vivo. Addressing this challenging goal requires a novel, biocompatible and scalable system to protect the deliverable mRNA from degradation in blood, escape the immune response, and provide high selectivity in cell targeting. The consortium will use AI/machine learning to generate a library of programmable RNano scaffolds for packaged mRNA and RNA aptamers for laser-specific internalisation of RNanos into cells. DESTINATION success could enable novel functions such as the production of a cell's own medicine by replacing the faulty mRNA or engineering cells to fight genetic disorders and cancer.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
W12 0BZ London
United Kingdom
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Participants (6)
00131 Roma
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
31008 Pamplona
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NE1 7RU Newcastle Upon Tyne
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5612 AE Eindhoven
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61612 Poznan
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
53113 Bonn
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