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AI-enabled RNA nanotechnology DElivery SysTem for INformATION transfer into cells.

Project description

Intelligent RNA-based delivery of new information into live cells

The EU-funded DESTINATION project aims to create a first-generation RNA-based delivery platform (RNano) for effective delivery of information (mRNA) into cells in vivo. Addressing this challenging goal requires a novel, biocompatible and scalable system to protect the deliverable mRNA from degradation in blood, escape the immune response, and provide high selectivity in cell targeting. The consortium will use AI/machine learning to generate a library of programmable RNano scaffolds for packaged mRNA and RNA aptamers for laser-specific internalisation of RNanos into cells. DESTINATION success could enable novel functions such as the production of a cell's own medicine by replacing the faulty mRNA or engineering cells to fight genetic disorders and cancer.

Call for proposal

H2020-FETOPEN-2018-2020

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Sub call

H2020-FETOPEN-2018-2019-2020-01

Coordinator

SIXFOLD BIOSCIENCE LTD
Net EU contribution
€ 886 250,00
Address
The Imperial College White City Inc Innovation Hub
W12 0BZ London
United Kingdom

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (6)

EXPLORA SRL
Italy
Net EU contribution
€ 492 473,75
Address
Via Giacomo Peroni 386
00131 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
Net EU contribution
€ 509 183,75
Address
Avenida De Pio Xii 55
31008 Pamplona

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Region
Noreste Comunidad Foral de Navarra Navarra
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 572 336,25
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Region
North East (England) Northumberland and Tyne and Wear Tyneside
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
Net EU contribution
€ 306 750,00
Address
Groene Loper 3
5612 AE Eindhoven

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUTURESYNTHESIS SP ZOO
Poland
Net EU contribution
€ 222 125,00
Address
Rubiez, Nr 46, Lok. B
61612 Poznan

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Makroregion północno-zachodni Wielkopolskie Miasto Poznań
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
Net EU contribution
€ 392 770,00
Address
Regina Pacis Weg 3
53113 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00