An innovative in vitro assay for screening lipid-based drugs
Although oral drug administration is the preferred method of choice for both patients and healthcare providers, most drug candidates exhibit low solubility in a water-based environment such as the gut. To increase drug solubility, researchers have developed lipid-based formulations (LBFs), which, however, are difficult to characterise in vivo and incur high drug development costs. The EU-funded DINAMIC project is working on an efficient, rapid and cost-effective in vitro assay that mimics the gut microenvironment and can be used to screen LBFs. The assay setup provides an integrated, more physiologically relevant description of LBF performance and drug bioavailability in less than an hour. DINAMIC will develop an assay prototype and undertake activities towards its commercialisation.
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