CORDIS
EU research results

CORDIS

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Preventing and reversing neuroinflammatory brain damage using local expansion of regulatory T cells

Project information

Grant agreement ID: 899863

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

Hosted by:

THE BABRAHAM INSTITUTE

United Kingdom

Objective

"A proposal to use local IL2 delivery via a viral vector to prevent and reverse the inflammatory damage that happens to the brain during neuroinflammatory diseases as diverse as traumatic brain injury, Multiple Sclerosis and Alzheimer's Disease. In ""TissueTregs"" we identified and characterised a brain-resident regulatory T cell population, with high expression of anti-inflammatory and reparative proteins. A synthetic circuit for deliver IL2 to the brain expanded this population, without any off-target increases in circulation or the blood. In order to translate these findings beyond the scope of the original ""TissueTregs"" grant, we have moved to a viral vector system, designed to give brain-specific expression of IL2. This systems demonstrates long-lasting brain-specific expansion of the brain-resident regulatory T cell population, after only a single intravenous injection. Preliminary results demonstrate a striking ability of this treatment to prevent neurological damage in mouse models of traumatic brain injury and Multiple Sclerosis. A provisional patent has been filed to cover this invention. In this PoC grant, we will run the necessary validation and target deconvolution experiments to pave the way for this treatment to move into the clinical sphere."
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Host institution

THE BABRAHAM INSTITUTE

Address

Babraham Hall
Cb22 3at Cambridge

United Kingdom

Activity type

Research Organisations

EU Contribution

€ 150 000

Beneficiaries (1)

THE BABRAHAM INSTITUTE

United Kingdom

EU Contribution

€ 150 000

Project information

Grant agreement ID: 899863

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

Hosted by:

THE BABRAHAM INSTITUTE

United Kingdom