Targeting the Achilles heel of cancer
Cancer cells often present with an imbalanced number of chromosomes or chromosomal translocations. Despite extensive research into the origin of aneuploidy, its underlying mechanisms have not been fully elucidated. The EU-funded CancerAneuploidy project aims to study the cellular consequences of aneuploidy. To achieve this, scientists will use state-of-the-art genomic approaches and chemical perturbation and investigate the evolution of aneuploidy in tumours. The discovery of the vulnerabilities caused by aneuploidy has the potential to be exploited for killing cancer cells. Collectively, the project's results will shed light on the biological enigma of aneuploidy and offer new opportunities for cancer therapy.
Fields of science
Call for proposal
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