Understanding and targeting the functional consequences of aneuploidy in cancer

Project Information

CancerAneuploidy

Grant agreement ID: 945674

DOI

10.3030/945674

EC signature date 2 December 2020

Start date 1 October 2021

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 612 500,00

EU contribution

€ 1 612 500,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q

Author(s): Dylan Stavish, Christopher J. Price, Gabriele Gelezauskaite, Haneen Alsehli, Kimberly A. Leonhard, Seth M. Taapken, Erik M. McIntire, Owen Laing, Bethany M. James, Jack J. Riley, Johanna Zerbib, Duncan Baker, Amy L. Harding, Lydia H. Jestice, Thomas F. Eleveld, Ad J.M. Gillis, Sanne Hillenius, Leendert H.J. Looijenga, Paul J. Gokhale, Uri Ben-David, Tenneille E. Ludwig, Ivana Barbaric
Published in: Stem Cell Reports, Issue 19, 2024, Page(s) 1217-1232, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2024.06.003

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Author(s): Nishanth Ulhas Nair, Alejandro A. Schäffer, E. Michael Gertz, Kuoyuan Cheng, Johanna Zerbib, Avinash Das Sahu, Gil Leor, Eldad D. Shulman, Kenneth D. Aldape, Uri Ben-David, Eytan Ruppin
Published in: Cancer Research, Issue 84, 2024, Page(s) 3464-3477, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-1366

Aneuploidy as a driver of human cancer

Author(s): Eran Sdeor, Hajime Okada, Ron Saad, Tal Ben-Yishay, Uri Ben-David
Published in: Nature Genetics, 2024, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-024-01916-2

CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments

Author(s): R Bhagya Lakshmi; Pinaki Nayak; Linoy Raz; Apurba Sarkar; Akshay Saroha; Pratibha Kumari; Vishnu M Nair; Delvin P Kombarakkaran; S Sajana; Sanusha M G; Sarit S Agasti; Raja Paul; Uri Ben-David; Tapas K Manna
Published in: Crossref, Issue 3, 2023, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.1038/s44319-024-00106-9

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Author(s): Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad D. Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tiangen Chang, Emma M. Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mülleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, France
Published in: Cancer Discovery, 2024, Page(s) OF1-OF22, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0309

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Author(s): Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52176-x

DNA-based copy number analysis confirms genomic evolution of PDX models

Author(s): Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha & Uri Ben-David
Published in: npj Precision Oncology, 2022, ISSN 2397-768X
Publisher: Springer Nature
DOI: 10.1038/s41698-022-00268-6

Short-term molecular consequences of chromosome mis-segregation for genome stability

Author(s): Lorenza Garribba; Giuseppina De Feudis; Valentino Martis; Martina Galli; Marie Dumont; Yonatan Eliezer; René Wardenaar; Marica Rosaria Ippolito; Divya Ramalingam Iyer; Andréa E. Tijhuis; Diana C. J. Spierings; Michael Schubert; Silvia Taglietti; Chiara Soriani; Simon Gemble; Renata Basto; Nick Rhind; Floris Foijer; Uri Ben-David; Daniele Fachinetti; Ylli Doksani; Stefano Santaguida
Published in: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Issue 2, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37095-7

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Author(s): Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben‑David and Esti Yeger‑Lotem
Published in: Genome Biology, 2024, ISSN 1474-7596
Publisher: BioMed Central
DOI: 10.1186/s13059-024-03225-7

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers

Author(s): Kavya Prasad; Mathew Bloomfield ; Hagai Levi ; Kristina Keuper ; Sara V. Bernhard; Nicolaas C. Baudoin; Gil Leor ; Yonatan Eliezer; Maybelline Giam; Cheng Kit Wong; Giulia Rancati; Zuzana Storchová ; Daniela Cimini ; Uri Ben-David
Published in: Cancer Research, 2022, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-21-2065

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Author(s): Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A. Mirono
Published in: Science, Issue 385, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adj7446

Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage

Author(s): Alessio David Nahmad, Eli Reuveni , Ella Goldschmidt , Tamar Tenne, Meytal Liberman, Miriam Horovitz-Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi, Uri Ben-David, Adi Barzel
Published in: nature biotechnology, 2022, ISSN 1546-1696
Publisher: Springer Nature
DOI: 10.1038/s41587-022-01377-0