Understanding and targeting the functional consequences of aneuploidy in cancer

Project Information

CancerAneuploidy

Grant agreement ID: 945674

DOI

10.3030/945674

EC signature date 2 December 2020

Start date 1 October 2021

End date 30 September 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 612 500,00

EU contribution

€ 1 612 500,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses

Author(s): Ron Saad, Ron Shamir, Uri Ben-David
Published in: Cell Reports, Issue 44, 2026, Page(s) 116455, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2025.116455

Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q

Author(s): Dylan Stavish, Christopher J. Price, Gabriele Gelezauskaite, Haneen Alsehli, Kimberly A. Leonhard, Seth M. Taapken, Erik M. McIntire, Owen Laing, Bethany M. James, Jack J. Riley, Johanna Zerbib, Duncan Baker, Amy L. Harding, Lydia H. Jestice, Thomas F. Eleveld, Ad J.M. Gillis, Sanne Hillenius, Leendert H.J. Looijenga, Paul J. Gokhale, Uri Ben-David, Tenneille E. Ludwig, Ivana Barbaric
Published in: Stem Cell Reports, Issue 19, 2024, Page(s) 1217-1232, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2024.06.003

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Author(s): Nishanth Ulhas Nair, Alejandro A. Schäffer, E. Michael Gertz, Kuoyuan Cheng, Johanna Zerbib, Avinash Das Sahu, Gil Leor, Eldad D. Shulman, Kenneth D. Aldape, Uri Ben-David, Eytan Ruppin
Published in: Cancer Research, Issue 84, 2024, Page(s) 3464-3477, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-1366

Aneuploidy as a driver of human cancer

Author(s): Eran Sdeor, Hajime Okada, Ron Saad, Tal Ben-Yishay, Uri Ben-David
Published in: Nature Genetics, 2024, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-024-01916-2

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly

Author(s): Ushma Anand, Amit Bloomberg, Pradip Bhattacharjee, Swarnendu Mukhopadhyay, Binshad Badarudeen, Shivani Ramakrishnan, Uri Ben-David, Tapas K. Manna
Published in: Journal of Biological Chemistry, Issue 302, 2026, Page(s) 111104, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.111104

CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments

Author(s): R Bhagya Lakshmi; Pinaki Nayak; Linoy Raz; Apurba Sarkar; Akshay Saroha; Pratibha Kumari; Vishnu M Nair; Delvin P Kombarakkaran; S Sajana; Sanusha M G; Sarit S Agasti; Raja Paul; Uri Ben-David; Tapas K Manna
Published in: Crossref, Issue 3, 2023, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.1038/s44319-024-00106-9

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism

Author(s): Kathrin Laue, Sabina Pozzi, Johanna Zerbib, Rebecca Bertolio, Yonatan Eliezer, Yael Cohen-Sharir, Tom Winkler, Manuel Caputo, Alessia A. Ricci, Lital Adler, Rami Khoury, Giuseppe Longobardi, Rachel Slutsky, Alicia I. Leikin-Frenkel, Shai Ovadia, Katharina Lange, Alessandra Rustighi, Silvano Piazza, Andrea Sacconi, Rayna Y. Magesh, Faith N. Keller, Jean Berthelet, Alexander Schäffer, Ron Saad, Sah
Published in: Nature Genetics, Issue 58, 2026, Page(s) 116-131, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02446-1

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Author(s): Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad D. Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tiangen Chang, Emma M. Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mülleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, France
Published in: Cancer Discovery, 2024, Page(s) OF1-OF22, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0309

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Author(s): Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52176-x

Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling

Author(s): Mathew Bloomfield, Sydney M. Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, Eva M. Schmelz, Uri Ben-David, Daniela Cimini
Published in: Cancer Research, Issue 86, 2026, Page(s) 2126-2142, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-3718

Evolutionary rescue by aneuploidy in tumors exposed to anticancer drugs

Author(s): Remus Stana, Uri Ben-David, Daniel B Weissman, Yoav Ram
Published in: GENETICS, Issue 230, 2025, ISSN 1943-2631
Publisher: Oxford University Press (OUP)
DOI: 10.1093/genetics/iyaf098

DNA-based copy number analysis confirms genomic evolution of PDX models

Author(s): Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha & Uri Ben-David
Published in: npj Precision Oncology, 2022, ISSN 2397-768X
Publisher: Springer Nature
DOI: 10.1038/s41698-022-00268-6

Short-term molecular consequences of chromosome mis-segregation for genome stability

Author(s): Lorenza Garribba; Giuseppina De Feudis; Valentino Martis; Martina Galli; Marie Dumont; Yonatan Eliezer; René Wardenaar; Marica Rosaria Ippolito; Divya Ramalingam Iyer; Andréa E. Tijhuis; Diana C. J. Spierings; Michael Schubert; Silvia Taglietti; Chiara Soriani; Simon Gemble; Renata Basto; Nick Rhind; Floris Foijer; Uri Ben-David; Daniele Fachinetti; Ylli Doksani; Stefano Santaguida
Published in: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Issue 2, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37095-7

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors

Author(s): Siqi Zheng, Linoy Raz, Lin Zhou, Yael Cohen-Sharir, Ruifang Tian, Marica Rosaria Ippolito, Sara Gianotti, Ron Saad, Rene Wardenaar, Mathilde Broekhuis, Maria Suarez Peredo Rodriguez, Soraya Wobben, Anouk van den Brink, Petra Bakker, Stefano Santaguida, Floris Foijer, Uri Ben-David
Published in: EMBO Reports, Issue 26, 2026, Page(s) 1036-1061, ISSN 1469-3178
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44319-024-00363-8

The cGAS–STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts

Author(s): Majd Haj, Yann Frey, Amit Levon, Avishai Maliah, Tal Ben-Yishay, Rachel Slutsky, Riham Smoom, Yehuda Tzfati, Uri Ben-David, Carmit Levy, Ran Elkon, Yael Ziv, Yosef Shiloh
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2419196122

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Author(s): Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben‑David and Esti Yeger‑Lotem
Published in: Genome Biology, 2024, ISSN 1474-7596
Publisher: BioMed Central
DOI: 10.1186/s13059-024-03225-7

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

Author(s): Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, Johanna Zerbib, Ross Smith, Jonne Raaijmakers, Pratiti Bandopadhayay, Lillian M. Guenther, Justin H. Hwang, Amanda Iniguez, Susan Moody, Ji-Heui Seo, Elizabeth H. Stover, Levi Garraway, William C. Hahn, Kimberly Stegmaier, René
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-56301-2

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers

Author(s): Kavya Prasad; Mathew Bloomfield ; Hagai Levi ; Kristina Keuper ; Sara V. Bernhard; Nicolaas C. Baudoin; Gil Leor ; Yonatan Eliezer; Maybelline Giam; Cheng Kit Wong; Giulia Rancati; Zuzana Storchová ; Daniela Cimini ; Uri Ben-David
Published in: Cancer Research, 2022, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-21-2065

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Author(s): Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A. Mirono
Published in: Science, Issue 385, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adj7446

Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage

Author(s): Alessio David Nahmad, Eli Reuveni , Ella Goldschmidt , Tamar Tenne, Meytal Liberman, Miriam Horovitz-Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi, Uri Ben-David, Adi Barzel
Published in: nature biotechnology, 2022, ISSN 1546-1696
Publisher: Springer Nature
DOI: 10.1038/s41587-022-01377-0