Descripción del proyecto
Quelantes de lantánidos inspirados en la naturaleza para unas tecnologías más ecológicas
Los lantánidos (Ln) son metales de tierras raras cuya purificación tiene un impacto ambiental negativo. Aunque estudios recientes han demostrado que muchas bacterias utilizan Ln para su crecimiento, así como en los centros activos de sus enzimas, su mecanismo de captación de Ln está todavía poco estudiado. El objetivo principal del proyecto LANTHANOPHOR, financiado con fondos europeos, es identificar los lantanidóforos y los péptidos inspirados en la naturaleza que pueden unirse a Ln, presentes en las bacterias que utilizan lantánidos. Las actividades del proyecto ayudarán a los científicos a comprender la biodisponibilidad de los Ln, lo que abrirá el camino a tecnologías más respetuosas con el medio ambiente para la separación y el reciclaje de Ln.
Objetivo
Lanthanides (Ln) are critical raw materials and designated with a high supply risk by the European Commission. Their mining and purification have a considerable negative environmental impact and we urgently need sustainable and efficient recycling strategies for these elements. It was recently discovered that many bacteria use Ln for growth and utilize them in the active sites of enzymes. In addition, a Ln-binding protein with unprecedented affinities for Ln (Lanmodulin, LanM) has been isolated from one of these bacteria. The Ln-uptake mechanisms of these bacteria remain vastly underexplored, however, the involvement of polydentate ligands (chelators) to bind lanthanides — lanthanophores (lanthanide carriers) — has recently been established. For the first time, practical applications of chelators that were specifically designed by nature to bind, recycle and separate the technologically-indispensable lanthanides are in reach. Thus, the objective of LANTHANOPHOR is the identification and isolation of lanthanophores from the spent media of lanthanide-utilizing bacteria and the synthesis of short peptides based on the Ln-binding moiety in LanM. A comprehensive characterization of the lanthanophore including their lanthanide coordination chemistry, will contribute to our understanding how Ln are made bioavailable inside bacterial cells. The lanthanophore and the peptides will be evaluated for the use in Ln separation and recycling. I will further elucidate whether these ligands can be used in lanthanide bioremediation or for medical applications as chelators. The results of LANTHANOPHOR will advance the development of sustainable solutions and bioinspired applications that are urgently needed in the quest for new, environmentally friendly and faster Ln separation and recycling technologies. The unique combination of lanthanide biochemistry and coordination chemistry in my group opens unparalleled opportunities for discovery and characterisation of lanthanophores.
Ámbito científico
- engineering and technologyenvironmental engineeringwaste managementwaste treatment processesrecycling
- natural sciencesbiological sciencesmicrobiologybacteriology
- engineering and technologyenvironmental biotechnologybioremediation
- engineering and technologyenvironmental engineeringmining and mineral processing
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Palabras clave
Programa(s)
Régimen de financiación
ERC-STG - Starting GrantInstitución de acogida
40225 Dusseldorf
Alemania