Dietary shaping of the early life metabolome and its role in healthy lung and brain development

Project Information

DEFEND

Grant agreement ID: 946228

DOI

10.3030/946228

EC signature date 29 January 2021

Start date 1 February 2021

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 952,00

EU contribution

€ 1 499 952,00

Coordinated by

REGION HOVEDSTADEN
Denmark

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (34)

The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review

Author(s): Mette S. Schjødt; Gözde Gürdeniz; Bo L. Chawes
Published in: Metabolites, Issue 1, 2020, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo10120511

Association of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life

Author(s): Nicklas Brustad, Fink NR, Stokholm J, Bønnelykke K, Følsgaard NV, Hougaard D, Brix S, Lasky-Su J, Weiss ST, Chawes B
Published in: Nutrients, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14010015.

Maternal vitamin D-related metabolome and offspring risk of asthma outcomes

Author(s): Min Kim, Nicklas Brustad, Mina Ali, Gürdeniz G, Arendt M, Litonjua AA, Wheelock CE, Kelly RS, Chen Y, Prince N, Guo F, Zhou X, Stokholm J, Bønnelykke K, Weiss ST, Bisgaard H, Lasky-Su J, Chawes B.
Published in: J Allergy Clin Immunol, 2023, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2023.06.030

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort

Author(s): Sevelsted A, Pedersen CT, Gürdeniz G, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Lasky-Su J, Morin A, Ober C, Schoos AM, Stokholm J, Bønnelykke K, Bo Chawes, Bisgaard H
Published in: eBioMedicine, 2023, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104699

Environmental and genetic associations with aberrant early-life gut microbial maturation in childhood asthma

Author(s): Yih-Chieh Chen; Yulu Chen; Jessica Lasky-Su; Rachel S. Kelly; Jakob Stokholm; Hans Bisgaard; Klaus Bønnelykke; Casper-Emil Tingskov Pedersen; Bo Chawes; Nancy Laranjo; Scott T. Weiss; Augusto A. Litonjua; Kathleen Lee-Sarwar
Published in: J Allergy Clin Immunol, Issue 1, 2023, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2023.01.006

Maternal Diet Associates with Offspring Bone Mineralization, Fracture Risk and Enamel Defects in Childhood and Influences the Prenatal Effect of High-Dose Vitamin D Supplementation

Author(s): Min Kim, Pia E. Nørrisgaard, Nilo Vahman, Olivier N. F. Cexus, Paul A. Townsend, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes, Nicklas Brustad
Published in: Nutrients, Issue 16, 2025, Page(s) 405, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16030405

Vitamin D‐FUT2 interaction and risk of lower respiratory tract infections in childhood

Author(s): Nicklas Brustad, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Published in: Allergy, Issue 80, 2025, Page(s) 582-584, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.16266

High dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial

Author(s): Nicklas Brustad, Chawes BL, Thorsen J, Krakauer M, Lasky-Su J, Weiss ST, Stokholm J, Bønnelykke K, Bisgaard H
Published in: eClinicalMedicine, 2021, ISSN 2589-5370
Publisher: Elsevier inc.
DOI: 10.1016/j.eclinm.2021.101254

Vitamin D in early life and risk of daily registered childhood infection episodes

Author(s): Nicklas Brustad, Julie Nyholm Kyvsgaard, Casper‐Emil Tingskov Pedersen, Laura Marie Hesselberg, Anders U. Eliasen, Signe Kjeldgaard Jensen, Luo Yang, Nilofar Vahman, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Published in: Allergy, Issue 80, 2025, Page(s) 332-335, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.16354

Prenatal high-dose vitamin D supplementation and childhood atopic dermatitis until age 6 years: a secondary analysis of a randomized clinical trial

Author(s): Nicklas Brustad, Tingting Wang, Liang Chen, Hannah Kaiser, Beatriz Gomes, Amalie Klein, Nilo Vahman, Lone Skov, Jakob Stokholm, Ann-Marie Schoos, Klaus Bønnelykke, Bo Chawes
Published in: British Journal of Dermatology, Issue 193, 2025, Page(s) 775-777, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/bjd/ljaf208

Air pollution-induced proteomic alterations increase the risk of child respiratory infections

Author(s): Nicklas Brustad, Tingting Wang, Shizhen He, Casper-Emil Tingskov Pedersen, Olena Gruzieva, Liang Chen, Göran Pershagen, Mina Ali, Julie Nyholm Kyvsgaard, Marie Pedersen, Matthias Ketzel, Heikki Hyöty, Daniel Agardh, Erik Melén, Jonathan Thorsen, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-61392-y

Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Author(s): Huang M, Kelly RS, Chu SH, Kachroo P, Gürdeniz G, Chawes BL, Bisgaard H, Weiss ST, Lasky-Su J
Published in: Metabolites, 2021, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo11020065

Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability

Author(s): Mario Lovrić, David Horner, Liang Chen, Nicklas Brustad, Ann-Marie Schoos, Jessica Lasky-Su, Bo Chawes, Morten Rasmussen
Published in: Metabolites, Issue 14, 2025, Page(s) 136, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14030136

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

Author(s): Sevelsted A, Gürdeniz G, Rago D, Pedersen CT, Lasky-Su JA, Checa A, Zhang P, Wheelock CE, Normann SS, Kristensen DM, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Stokholm J, Bønnelykke K, Bisgaard H, Chawes B
Published in: eBioMedicine, 2022, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104236.

A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence

Author(s): David Horner, Jens Richardt M. Jepsen, Bo Chawes, Kristina Aagaard, Julie B. Rosenberg, Parisa Mohammadzadeh, Astrid Sevelsted, Nilo Vahman, Rebecca Vinding, Birgitte Fagerlund, Christos Pantelis, Niels Bilenberg, Casper-Emil T. Pedersen, Anders Eliasen, Sarah Brandt, Yulu Chen, Nicole Prince, Su H. Chu, Rachel S. Kelly, Jessica Lasky-Su, Thorhallur I. Halldorsson, Marin Strøm, Katrine Strandberg
Published in: Nature Metabolism, Issue 7, 2025, Page(s) 586-601, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-025-01230-z

Vertical Transfer of Metabolites Detectable from Newborn’s Dried Blood Spot Samples Using UPLC-MS: A Chemometric Study

Author(s): Olarini A, Ernst M, Gürdeniz G, Min Kim, Nicklas Brustad, Bønnelykke K, Cohen A, Hougaard D, Lasky-Su J, Bisgaard H, Chawes B, Rasmussen MA
Published in: Metabolites, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12020094.

Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts

Author(s): Nicole Prince; Min Kim; Rachel S. Kelly; Joann Diray-Arce; Klaus Bønnelykke; Bo L. Chawes; Mengna Huang; Ofer Levy; Augusto A. Litonjua; Jakob Stokholm; Craig E. Wheelock; Hans Bisgaard; Scott T. Weiss; Jessica A. Lasky-Su
Published in: Metabolites, Issue 1, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12111108

Effects of prenatal nutrient supplementation and early life exposures on neurodevelopment at age 10: a randomised controlled trial - the COPSYCH study protocol

Author(s): Parisa Mohammadzadeh; Julie Bøjstrup Rosenberg; Rebecca Vinding; Jens Richardt Møllegaard Jepsen; Ulrich Lindberg; Nilo Følsgaard; Mikkel Erlang Sørensen; Daban Sulaiman; Niels Bilenberg; Jayachandra Mitta Raghava; Birgitte Fagerlund; Mark Vestergaard; Christos Pantelis; Jakob Stokholm; Bo Chawes; Henrik Larsson; Birte Yding Glenthøj; Klaus Bønnelykke; Bjørn H Ebdrup; Hans Bisgaard
Published in: BMJ Open, Issue 1, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-047706

Maternal dietary patterns, breastfeeding duration, and their association with child cognitive function and head circumference growth: A prospective mother–child cohort study

Author(s): David Horner, Jens Richardt Møllegaard Jepsen, Bo Chawes, Rebecca Vinding, Julie B. Rosenberg, Parisa Mohammadzadeh, Yang Luo, Birgitte Fagerlund, Trine Flensborg-Madsen, Thomas Ragnar Wood, Janine F. Felix, Louise Monnerup, Birte Y. Glenthøj, Klaus Bønnelykke, Bjørn H. Ebdrup, Jakob Stokholm, Morten Arendt Rasmussen
Published in: PLOS Medicine, Issue 22, 2025, Page(s) e1004454, ISSN 1549-1676
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pmed.1004454

Neonatal metabolome of caesarean section and risk of childhood asthma

Author(s): Gözde Gürdeniz; Madeleine Ernst; Daniela Rago; Min Kim; Julie Courraud; Jakob Stokholm; Klaus Bønnelykke; Anders Björkbom; Urvish Trivedi; Søren J. Sørensen; Susanne Brix; David Hougaard; Morten Rasmussen; Arieh S. Cohen; Hans Bisgaard; Bo Chawes
Published in: European Respiratory Journal, 2022, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.02406-2021

Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial.

Author(s): Lærke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo L. Chawes; Rebecca K. Vinding; Anna-Rosa Cecilie Mora-Jensen; Jonathan Thorsen; Sarah Noergaard; Bjørn H Ebdrup; Jens Richardt Møllegaard Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard
Published in: Child Development, 2021, ISSN 0009-3920
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13541

High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

Author(s): Nicklas Brustad; Jens H. Greve; Hooman Mirzakhani; Casper-Emil T. Pedersen; Anders U. Eliasen; Jakob Stokholm; Jessica Lasky-Su; Klaus Bønnelykke; Augusto A. Litonjua; Scott T. Weiss; Hans Bisgaard; Bo L. Chawes
Published in: Pediatric Allergy and Immunology, 2021, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.13453

25‐hydroxyvitamin D and risk of atopic diseases and infections in early childhood

Author(s): Nicklas Brustad, Min Kim, Frederikke Skov, Ann‐Marie Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Published in: Allergy, Issue 78, 2023, Page(s) 2770-2773, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.15759

Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis

Author(s): Liang Chen, Nicklas Brustad, Yang Luo, Tingting Wang, Mina Ali, Parvaneh Ebrahimi, Ann-Marie M. Schoos, Nilo Vahman, Mario Lovrić, Morten A. Rasmussen, Johan Kolmert, Craig E. Wheelock, Jessica A. Lasky-Su, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Published in: JAMA Dermatology, Issue 160, 2024, Page(s) 1082, ISSN 2168-6068
Publisher: American Medical Association
DOI: 10.1001/jamadermatol.2024.2849

High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial

Author(s): Kristina Aagaard, Jens Richardt Møllegaard Jepsen, Astrid Sevelsted, David Horner, Rebecca Vinding, Julie Bøjstrup Rosenberg, Nicklas Brustad, Anders Eliasen, Parisa Mohammadzadeh, Nilofar Følsgaard, María Hernández-Lorca, Birgitte Fagerlund, Birte Y. Glenthøj, Morten Arendt Rasmussen, Niels Bilenberg, Jakob Stokholm, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes
Published in: The American Journal of Clinical Nutrition, Issue 119, 2025, Page(s) 362-370, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1016/j.ajcnut.2023.12.002

Furan fatty acid metabolite in newborns predicts risk of asthma

Author(s): Gözde Gürdeniz; Min Kim; Nicklas Brustad; Madeleine Ernst; Francesco Russo; Jakob Stokholm; Klaus Bønnelykke; David Hougaard; Morten Rasmussen; Arieh Cohen; Bo Chawes
Published in: Allergy, 2022, ISSN 1398-9995
Publisher: Wiley
DOI: 10.1111/all.15554

Diet‐associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood

Author(s): Nicklas Brustad; Alessandra Olarini; Min Kim; Liang Chen; Mina Ali; Tingting Wang; Arieh S. Cohen; Madeleine Ernst; David Hougaard; Ann‐Marie Schoos; Jakob Stokholm; Klaus Bønnelykke; Jessica Lasky‐Su; Morten A. Rasmussen; Bo Chawes
Published in: Ped Allergy Immunol, Issue 2, 2023, ISSN 1399-3038
Publisher: Wiley
DOI: 10.1111/pai.13917

A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation

Author(s): Mario Lovrić, Tingting Wang, Mads Rønnow Staffe, Iva Šunić, Kristina Časni, Jessica Lasky-Su, Bo Chawes, Morten Arendt Rasmussen
Published in: Metabolites, Issue 14, 2025, Page(s) 278, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14050278

Elevated third trimester corticosteroid levels are associated with fewer offspring infections

Author(s): Prince N, Kelly RS, Chu SH, Kachroo P, Chen Y, Mendez KM, Begum S, Bisgaard H, Bønnelykke K, Min Kim, Levy O, Litonjua AA, Wheelock CE, Weiss ST, Chawes B, Lasky-Su JA.
Published in: Sci Rep, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-36535-0

Dietary prevention strategies for childhood asthma

Author(s): Nicklas Brustad, Klaus Bønnelykke, Bo Chawes
Published in: Pediatric Allergy and Immunology, Issue 34, 2023, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.13984

Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

Author(s): Hanna M. Knihtilä; Rachel S. Kelly; Nicklas Brustad; Nicklas Brustad; Mengna Huang; Priyadarshini Kachroo; Bo L. Chawes; Jakob Stokholm; Klaus Bønnelykke; Casper-Emil T. Pedersen; Hans Bisgaard; Augusto A. Litonjua; Jessica Lasky-Su; Scott T. Weiss
Published in: European Respiratory Journal, 2021, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.02012-2020

Vitamin D Primary Prevention of Respiratory Infections and Asthma in Early Childhood: Evidence and Mechanisms

Author(s): Nicklas Brustad, Bo Chawes
Published in: The Journal of Allergy and Clinical Immunology: In Practice, Issue 12, 2024, Page(s) 1707-1714, ISSN 2213-2198
Publisher: Elsevier
DOI: 10.1016/j.jaip.2024.02.005

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype.

Author(s): Rago D, Pedersen CT, Huang M, Kelly RS, Gürdeniz G, Nicklas Brustad, Knihtil H, Lee-Sarwar KA, Morin A, Rasmussen MA, Stokholm J, Bønnelykke K, Litonjua AA, Wheelock CE, Weiss ST, Lasky-Su J, Bisgaard H, Chawes BL
Published in: American Journal of Respiratory and Critical care Medicine, 2021, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202008-3206oc.

Urinary eicosanoid levels in early life and risk of atopic disease in childhood

Author(s): Liang Chen, Nicklas Brustad, Min Kim, Yang Luo, Tingting Wang, Mina Ali, Nicole Prince, Yulu Chen, Su Chu, Sofina Begum, Kevin Mendez, Rachel S. Kelly, Ann-Marie Schoos, Morten A. Rasmussen, Javier Zurita, Johan Kolmert, Jakob Stokholm, Augusto Litonjua, Scott T. Weiss, Klaus Bønnelykke, Craig E. Wheelock, Jessica Lasky-Su, Bo Chawes
Published in: Journal of Allergy and Clinical Immunology, Issue 154, 2024, Page(s) 670-678, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2024.05.022