Dietary shaping of the early life metabolome and its role in healthy lung and brain development

Project Information

DEFEND

Grant agreement ID: 946228

DOI 10.3030/946228

EC signature date 29 January 2021

Start date 1 February 2021

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 952,00

EU contribution € 1 499 952,00

Coordinated by

REGION HOVEDSTADEN
Denmark

Publications

Peer reviewed articles (19)

The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review

Author(s): Mette S. Schjødt; Gözde Gürdeniz; Bo L. Chawes
Published in: Metabolites, Issue 1, 2020, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo10120511

Association of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life

Author(s): Nicklas Brustad, Fink NR, Stokholm J, Bønnelykke K, Følsgaard NV, Hougaard D, Brix S, Lasky-Su J, Weiss ST, Chawes B
Published in: Nutrients, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14010015.

Maternal vitamin D-related metabolome and offspring risk of asthma outcomes

Author(s): Min Kim, Nicklas Brustad, Mina Ali, Gürdeniz G, Arendt M, Litonjua AA, Wheelock CE, Kelly RS, Chen Y, Prince N, Guo F, Zhou X, Stokholm J, Bønnelykke K, Weiss ST, Bisgaard H, Lasky-Su J, Chawes B.
Published in: J Allergy Clin Immunol, 2023, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2023.06.030

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort

Author(s): Sevelsted A, Pedersen CT, Gürdeniz G, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Lasky-Su J, Morin A, Ober C, Schoos AM, Stokholm J, Bønnelykke K, Bo Chawes, Bisgaard H
Published in: eBioMedicine, 2023, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104699

Environmental and genetic associations with aberrant early-life gut microbial maturation in childhood asthma

Author(s): Yih-Chieh Chen; Yulu Chen; Jessica Lasky-Su; Rachel S. Kelly; Jakob Stokholm; Hans Bisgaard; Klaus Bønnelykke; Casper-Emil Tingskov Pedersen; Bo Chawes; Nancy Laranjo; Scott T. Weiss; Augusto A. Litonjua; Kathleen Lee-Sarwar
Published in: J Allergy Clin Immunol, Issue 1, 2023, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2023.01.006

High dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial

Author(s): Nicklas Brustad, Chawes BL, Thorsen J, Krakauer M, Lasky-Su J, Weiss ST, Stokholm J, Bønnelykke K, Bisgaard H
Published in: eClinicalMedicine, 2021, ISSN 2589-5370
Publisher: Elsevier inc.
DOI: 10.1016/j.eclinm.2021.101254

Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Author(s): Huang M, Kelly RS, Chu SH, Kachroo P, Gürdeniz G, Chawes BL, Bisgaard H, Weiss ST, Lasky-Su J
Published in: Metabolites, 2021, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo11020065

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

Author(s): Sevelsted A, Gürdeniz G, Rago D, Pedersen CT, Lasky-Su JA, Checa A, Zhang P, Wheelock CE, Normann SS, Kristensen DM, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Stokholm J, Bønnelykke K, Bisgaard H, Chawes B
Published in: eBioMedicine, 2022, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104236.

Vertical Transfer of Metabolites Detectable from Newborn’s Dried Blood Spot Samples Using UPLC-MS: A Chemometric Study

Author(s): Olarini A, Ernst M, Gürdeniz G, Min Kim, Nicklas Brustad, Bønnelykke K, Cohen A, Hougaard D, Lasky-Su J, Bisgaard H, Chawes B, Rasmussen MA
Published in: Metabolites, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12020094.

Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts

Author(s): Nicole Prince; Min Kim; Rachel S. Kelly; Joann Diray-Arce; Klaus Bønnelykke; Bo L. Chawes; Mengna Huang; Ofer Levy; Augusto A. Litonjua; Jakob Stokholm; Craig E. Wheelock; Hans Bisgaard; Scott T. Weiss; Jessica A. Lasky-Su
Published in: Metabolites, Issue 1, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12111108

Effects of prenatal nutrient supplementation and early life exposures on neurodevelopment at age 10: a randomised controlled trial - the COPSYCH study protocol

Author(s): Parisa Mohammadzadeh; Julie Bøjstrup Rosenberg; Rebecca Vinding; Jens Richardt Møllegaard Jepsen; Ulrich Lindberg; Nilo Følsgaard; Mikkel Erlang Sørensen; Daban Sulaiman; Niels Bilenberg; Jayachandra Mitta Raghava; Birgitte Fagerlund; Mark Vestergaard; Christos Pantelis; Jakob Stokholm; Bo Chawes; Henrik Larsson; Birte Yding Glenthøj; Klaus Bønnelykke; Bjørn H Ebdrup; Hans Bisgaard
Published in: BMJ Open, Issue 1, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-047706

Neonatal metabolome of caesarean section and risk of childhood asthma

Author(s): Gözde Gürdeniz; Madeleine Ernst; Daniela Rago; Min Kim; Julie Courraud; Jakob Stokholm; Klaus Bønnelykke; Anders Björkbom; Urvish Trivedi; Søren J. Sørensen; Susanne Brix; David Hougaard; Morten Rasmussen; Arieh S. Cohen; Hans Bisgaard; Bo Chawes
Published in: European Respiratory Journal, 2022, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.02406-2021

Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial.

Author(s): Lærke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo L. Chawes; Rebecca K. Vinding; Anna-Rosa Cecilie Mora-Jensen; Jonathan Thorsen; Sarah Noergaard; Bjørn H Ebdrup; Jens Richardt Møllegaard Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard
Published in: Child Development, 2021, ISSN 0009-3920
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13541

High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

Author(s): Nicklas Brustad; Jens H. Greve; Hooman Mirzakhani; Casper-Emil T. Pedersen; Anders U. Eliasen; Jakob Stokholm; Jessica Lasky-Su; Klaus Bønnelykke; Augusto A. Litonjua; Scott T. Weiss; Hans Bisgaard; Bo L. Chawes
Published in: Pediatric Allergy and Immunology, 2021, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.13453

Furan fatty acid metabolite in newborns predicts risk of asthma

Author(s): Gözde Gürdeniz; Min Kim; Nicklas Brustad; Madeleine Ernst; Francesco Russo; Jakob Stokholm; Klaus Bønnelykke; David Hougaard; Morten Rasmussen; Arieh Cohen; Bo Chawes
Published in: Allergy, 2022, ISSN 1398-9995
Publisher: Wiley
DOI: 10.1111/all.15554

Diet‐associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood

Author(s): Nicklas Brustad; Alessandra Olarini; Min Kim; Liang Chen; Mina Ali; Tingting Wang; Arieh S. Cohen; Madeleine Ernst; David Hougaard; Ann‐Marie Schoos; Jakob Stokholm; Klaus Bønnelykke; Jessica Lasky‐Su; Morten A. Rasmussen; Bo Chawes
Published in: Ped Allergy Immunol, Issue 2, 2023, ISSN 1399-3038
Publisher: Wiley
DOI: 10.1111/pai.13917

Elevated third trimester corticosteroid levels are associated with fewer offspring infections

Author(s): Prince N, Kelly RS, Chu SH, Kachroo P, Chen Y, Mendez KM, Begum S, Bisgaard H, Bønnelykke K, Min Kim, Levy O, Litonjua AA, Wheelock CE, Weiss ST, Chawes B, Lasky-Su JA.
Published in: Sci Rep, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-36535-0

Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

Author(s): Hanna M. Knihtilä; Rachel S. Kelly; Nicklas Brustad; Nicklas Brustad; Mengna Huang; Priyadarshini Kachroo; Bo L. Chawes; Jakob Stokholm; Klaus Bønnelykke; Casper-Emil T. Pedersen; Hans Bisgaard; Augusto A. Litonjua; Jessica Lasky-Su; Scott T. Weiss
Published in: European Respiratory Journal, 2021, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.02012-2020

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype.

Author(s): Rago D, Pedersen CT, Huang M, Kelly RS, Gürdeniz G, Nicklas Brustad, Knihtil H, Lee-Sarwar KA, Morin A, Rasmussen MA, Stokholm J, Bønnelykke K, Litonjua AA, Wheelock CE, Weiss ST, Lasky-Su J, Bisgaard H, Chawes BL
Published in: American Journal of Respiratory and Critical care Medicine, 2021, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202008-3206oc.