Dietary shaping of the early life metabolome and its role in healthy lung and brain development

Informacje na temat projektu

DEFEND

Identyfikator umowy o grant: 946228

DOI

10.3030/946228

Data podpisania przez KE 29 Stycznia 2021

Data rozpoczęcia 1 Lutego 2021

Data zakończenia 31 Stycznia 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 499 952,00

Wkład UE

€ 1 499 952,00

Koordynowany przez

REGION HOVEDSTADEN
Denmark

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (34)

The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review

Autorzy: Mette S. Schjødt; Gözde Gürdeniz; Bo L. Chawes
Opublikowane w: Metabolites, Numer 1, 2020, ISSN 2218-1989
Wydawca: MDPI
DOI: 10.3390/metabo10120511

Association of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life

Autorzy: Nicklas Brustad, Fink NR, Stokholm J, Bønnelykke K, Følsgaard NV, Hougaard D, Brix S, Lasky-Su J, Weiss ST, Chawes B
Opublikowane w: Nutrients, 2021, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14010015.

Maternal vitamin D-related metabolome and offspring risk of asthma outcomes

Autorzy: Min Kim, Nicklas Brustad, Mina Ali, Gürdeniz G, Arendt M, Litonjua AA, Wheelock CE, Kelly RS, Chen Y, Prince N, Guo F, Zhou X, Stokholm J, Bønnelykke K, Weiss ST, Bisgaard H, Lasky-Su J, Chawes B.
Opublikowane w: J Allergy Clin Immunol, 2023, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2023.06.030

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort

Autorzy: Sevelsted A, Pedersen CT, Gürdeniz G, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Lasky-Su J, Morin A, Ober C, Schoos AM, Stokholm J, Bønnelykke K, Bo Chawes, Bisgaard H
Opublikowane w: eBioMedicine, 2023, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104699

Environmental and genetic associations with aberrant early-life gut microbial maturation in childhood asthma

Autorzy: Yih-Chieh Chen; Yulu Chen; Jessica Lasky-Su; Rachel S. Kelly; Jakob Stokholm; Hans Bisgaard; Klaus Bønnelykke; Casper-Emil Tingskov Pedersen; Bo Chawes; Nancy Laranjo; Scott T. Weiss; Augusto A. Litonjua; Kathleen Lee-Sarwar
Opublikowane w: J Allergy Clin Immunol, Numer 1, 2023, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2023.01.006

Maternal Diet Associates with Offspring Bone Mineralization, Fracture Risk and Enamel Defects in Childhood and Influences the Prenatal Effect of High-Dose Vitamin D Supplementation

Autorzy: Min Kim, Pia E. Nørrisgaard, Nilo Vahman, Olivier N. F. Cexus, Paul A. Townsend, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes, Nicklas Brustad
Opublikowane w: Nutrients, Numer 16, 2025, Strona(/y) 405, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16030405

Vitamin D‐FUT2 interaction and risk of lower respiratory tract infections in childhood

Autorzy: Nicklas Brustad, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Opublikowane w: Allergy, Numer 80, 2025, Strona(/y) 582-584, ISSN 0105-4538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/all.16266

High dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial

Autorzy: Nicklas Brustad, Chawes BL, Thorsen J, Krakauer M, Lasky-Su J, Weiss ST, Stokholm J, Bønnelykke K, Bisgaard H
Opublikowane w: eClinicalMedicine, 2021, ISSN 2589-5370
Wydawca: Elsevier inc.
DOI: 10.1016/j.eclinm.2021.101254

Vitamin D in early life and risk of daily registered childhood infection episodes

Autorzy: Nicklas Brustad, Julie Nyholm Kyvsgaard, Casper‐Emil Tingskov Pedersen, Laura Marie Hesselberg, Anders U. Eliasen, Signe Kjeldgaard Jensen, Luo Yang, Nilofar Vahman, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Opublikowane w: Allergy, Numer 80, 2025, Strona(/y) 332-335, ISSN 0105-4538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/all.16354

Prenatal high-dose vitamin D supplementation and childhood atopic dermatitis until age 6 years: a secondary analysis of a randomized clinical trial

Autorzy: Nicklas Brustad, Tingting Wang, Liang Chen, Hannah Kaiser, Beatriz Gomes, Amalie Klein, Nilo Vahman, Lone Skov, Jakob Stokholm, Ann-Marie Schoos, Klaus Bønnelykke, Bo Chawes
Opublikowane w: British Journal of Dermatology, Numer 193, 2025, Strona(/y) 775-777, ISSN 0007-0963
Wydawca: Blackwell Publishing Inc.
DOI: 10.1093/bjd/ljaf208

Air pollution-induced proteomic alterations increase the risk of child respiratory infections

Autorzy: Nicklas Brustad, Tingting Wang, Shizhen He, Casper-Emil Tingskov Pedersen, Olena Gruzieva, Liang Chen, Göran Pershagen, Mina Ali, Julie Nyholm Kyvsgaard, Marie Pedersen, Matthias Ketzel, Heikki Hyöty, Daniel Agardh, Erik Melén, Jonathan Thorsen, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-61392-y

Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Autorzy: Huang M, Kelly RS, Chu SH, Kachroo P, Gürdeniz G, Chawes BL, Bisgaard H, Weiss ST, Lasky-Su J
Opublikowane w: Metabolites, 2021, ISSN 2218-1989
Wydawca: MDPI
DOI: 10.3390/metabo11020065

Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability

Autorzy: Mario Lovrić, David Horner, Liang Chen, Nicklas Brustad, Ann-Marie Schoos, Jessica Lasky-Su, Bo Chawes, Morten Rasmussen
Opublikowane w: Metabolites, Numer 14, 2025, Strona(/y) 136, ISSN 2218-1989
Wydawca: MDPI AG
DOI: 10.3390/metabo14030136

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

Autorzy: Sevelsted A, Gürdeniz G, Rago D, Pedersen CT, Lasky-Su JA, Checa A, Zhang P, Wheelock CE, Normann SS, Kristensen DM, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Stokholm J, Bønnelykke K, Bisgaard H, Chawes B
Opublikowane w: eBioMedicine, 2022, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104236.

A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence

Autorzy: David Horner, Jens Richardt M. Jepsen, Bo Chawes, Kristina Aagaard, Julie B. Rosenberg, Parisa Mohammadzadeh, Astrid Sevelsted, Nilo Vahman, Rebecca Vinding, Birgitte Fagerlund, Christos Pantelis, Niels Bilenberg, Casper-Emil T. Pedersen, Anders Eliasen, Sarah Brandt, Yulu Chen, Nicole Prince, Su H. Chu, Rachel S. Kelly, Jessica Lasky-Su, Thorhallur I. Halldorsson, Marin Strøm, Katrine Strandberg
Opublikowane w: Nature Metabolism, Numer 7, 2025, Strona(/y) 586-601, ISSN 2522-5812
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s42255-025-01230-z

Vertical Transfer of Metabolites Detectable from Newborn’s Dried Blood Spot Samples Using UPLC-MS: A Chemometric Study

Autorzy: Olarini A, Ernst M, Gürdeniz G, Min Kim, Nicklas Brustad, Bønnelykke K, Cohen A, Hougaard D, Lasky-Su J, Bisgaard H, Chawes B, Rasmussen MA
Opublikowane w: Metabolites, 2022, ISSN 2218-1989
Wydawca: MDPI
DOI: 10.3390/metabo12020094.

Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts

Autorzy: Nicole Prince; Min Kim; Rachel S. Kelly; Joann Diray-Arce; Klaus Bønnelykke; Bo L. Chawes; Mengna Huang; Ofer Levy; Augusto A. Litonjua; Jakob Stokholm; Craig E. Wheelock; Hans Bisgaard; Scott T. Weiss; Jessica A. Lasky-Su
Opublikowane w: Metabolites, Numer 1, 2022, ISSN 2218-1989
Wydawca: MDPI
DOI: 10.3390/metabo12111108

Effects of prenatal nutrient supplementation and early life exposures on neurodevelopment at age 10: a randomised controlled trial - the COPSYCH study protocol

Autorzy: Parisa Mohammadzadeh; Julie Bøjstrup Rosenberg; Rebecca Vinding; Jens Richardt Møllegaard Jepsen; Ulrich Lindberg; Nilo Følsgaard; Mikkel Erlang Sørensen; Daban Sulaiman; Niels Bilenberg; Jayachandra Mitta Raghava; Birgitte Fagerlund; Mark Vestergaard; Christos Pantelis; Jakob Stokholm; Bo Chawes; Henrik Larsson; Birte Yding Glenthøj; Klaus Bønnelykke; Bjørn H Ebdrup; Hans Bisgaard
Opublikowane w: BMJ Open, Numer 1, 2022, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-047706

Maternal dietary patterns, breastfeeding duration, and their association with child cognitive function and head circumference growth: A prospective mother–child cohort study

Autorzy: David Horner, Jens Richardt Møllegaard Jepsen, Bo Chawes, Rebecca Vinding, Julie B. Rosenberg, Parisa Mohammadzadeh, Yang Luo, Birgitte Fagerlund, Trine Flensborg-Madsen, Thomas Ragnar Wood, Janine F. Felix, Louise Monnerup, Birte Y. Glenthøj, Klaus Bønnelykke, Bjørn H. Ebdrup, Jakob Stokholm, Morten Arendt Rasmussen
Opublikowane w: PLOS Medicine, Numer 22, 2025, Strona(/y) e1004454, ISSN 1549-1676
Wydawca: Public Library of Science (PLoS)
DOI: 10.1371/journal.pmed.1004454

Neonatal metabolome of caesarean section and risk of childhood asthma

Autorzy: Gözde Gürdeniz; Madeleine Ernst; Daniela Rago; Min Kim; Julie Courraud; Jakob Stokholm; Klaus Bønnelykke; Anders Björkbom; Urvish Trivedi; Søren J. Sørensen; Susanne Brix; David Hougaard; Morten Rasmussen; Arieh S. Cohen; Hans Bisgaard; Bo Chawes
Opublikowane w: European Respiratory Journal, 2022, ISSN 0903-1936
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.02406-2021

Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial.

Autorzy: Lærke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo L. Chawes; Rebecca K. Vinding; Anna-Rosa Cecilie Mora-Jensen; Jonathan Thorsen; Sarah Noergaard; Bjørn H Ebdrup; Jens Richardt Møllegaard Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard
Opublikowane w: Child Development, 2021, ISSN 0009-3920
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13541

High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

Autorzy: Nicklas Brustad; Jens H. Greve; Hooman Mirzakhani; Casper-Emil T. Pedersen; Anders U. Eliasen; Jakob Stokholm; Jessica Lasky-Su; Klaus Bønnelykke; Augusto A. Litonjua; Scott T. Weiss; Hans Bisgaard; Bo L. Chawes
Opublikowane w: Pediatric Allergy and Immunology, 2021, ISSN 0905-6157
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/pai.13453

25‐hydroxyvitamin D and risk of atopic diseases and infections in early childhood

Autorzy: Nicklas Brustad, Min Kim, Frederikke Skov, Ann‐Marie Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Opublikowane w: Allergy, Numer 78, 2023, Strona(/y) 2770-2773, ISSN 0105-4538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/all.15759

Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis

Autorzy: Liang Chen, Nicklas Brustad, Yang Luo, Tingting Wang, Mina Ali, Parvaneh Ebrahimi, Ann-Marie M. Schoos, Nilo Vahman, Mario Lovrić, Morten A. Rasmussen, Johan Kolmert, Craig E. Wheelock, Jessica A. Lasky-Su, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Opublikowane w: JAMA Dermatology, Numer 160, 2024, Strona(/y) 1082, ISSN 2168-6068
Wydawca: American Medical Association
DOI: 10.1001/jamadermatol.2024.2849

High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial

Autorzy: Kristina Aagaard, Jens Richardt Møllegaard Jepsen, Astrid Sevelsted, David Horner, Rebecca Vinding, Julie Bøjstrup Rosenberg, Nicklas Brustad, Anders Eliasen, Parisa Mohammadzadeh, Nilofar Følsgaard, María Hernández-Lorca, Birgitte Fagerlund, Birte Y. Glenthøj, Morten Arendt Rasmussen, Niels Bilenberg, Jakob Stokholm, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes
Opublikowane w: The American Journal of Clinical Nutrition, Numer 119, 2025, Strona(/y) 362-370, ISSN 0002-9165
Wydawca: American Society for Clinical Nutrition, Inc.
DOI: 10.1016/j.ajcnut.2023.12.002

Furan fatty acid metabolite in newborns predicts risk of asthma

Autorzy: Gözde Gürdeniz; Min Kim; Nicklas Brustad; Madeleine Ernst; Francesco Russo; Jakob Stokholm; Klaus Bønnelykke; David Hougaard; Morten Rasmussen; Arieh Cohen; Bo Chawes
Opublikowane w: Allergy, 2022, ISSN 1398-9995
Wydawca: Wiley
DOI: 10.1111/all.15554

Diet‐associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood

Autorzy: Nicklas Brustad; Alessandra Olarini; Min Kim; Liang Chen; Mina Ali; Tingting Wang; Arieh S. Cohen; Madeleine Ernst; David Hougaard; Ann‐Marie Schoos; Jakob Stokholm; Klaus Bønnelykke; Jessica Lasky‐Su; Morten A. Rasmussen; Bo Chawes
Opublikowane w: Ped Allergy Immunol, Numer 2, 2023, ISSN 1399-3038
Wydawca: Wiley
DOI: 10.1111/pai.13917

A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation

Autorzy: Mario Lovrić, Tingting Wang, Mads Rønnow Staffe, Iva Šunić, Kristina Časni, Jessica Lasky-Su, Bo Chawes, Morten Arendt Rasmussen
Opublikowane w: Metabolites, Numer 14, 2025, Strona(/y) 278, ISSN 2218-1989
Wydawca: MDPI AG
DOI: 10.3390/metabo14050278

Elevated third trimester corticosteroid levels are associated with fewer offspring infections

Autorzy: Prince N, Kelly RS, Chu SH, Kachroo P, Chen Y, Mendez KM, Begum S, Bisgaard H, Bønnelykke K, Min Kim, Levy O, Litonjua AA, Wheelock CE, Weiss ST, Chawes B, Lasky-Su JA.
Opublikowane w: Sci Rep, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-36535-0

Dietary prevention strategies for childhood asthma

Autorzy: Nicklas Brustad, Klaus Bønnelykke, Bo Chawes
Opublikowane w: Pediatric Allergy and Immunology, Numer 34, 2023, ISSN 0905-6157
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/pai.13984

Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

Autorzy: Hanna M. Knihtilä; Rachel S. Kelly; Nicklas Brustad; Nicklas Brustad; Mengna Huang; Priyadarshini Kachroo; Bo L. Chawes; Jakob Stokholm; Klaus Bønnelykke; Casper-Emil T. Pedersen; Hans Bisgaard; Augusto A. Litonjua; Jessica Lasky-Su; Scott T. Weiss
Opublikowane w: European Respiratory Journal, 2021, ISSN 0903-1936
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.02012-2020

Vitamin D Primary Prevention of Respiratory Infections and Asthma in Early Childhood: Evidence and Mechanisms

Autorzy: Nicklas Brustad, Bo Chawes
Opublikowane w: The Journal of Allergy and Clinical Immunology: In Practice, Numer 12, 2024, Strona(/y) 1707-1714, ISSN 2213-2198
Wydawca: Elsevier
DOI: 10.1016/j.jaip.2024.02.005

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype.

Autorzy: Rago D, Pedersen CT, Huang M, Kelly RS, Gürdeniz G, Nicklas Brustad, Knihtil H, Lee-Sarwar KA, Morin A, Rasmussen MA, Stokholm J, Bønnelykke K, Litonjua AA, Wheelock CE, Weiss ST, Lasky-Su J, Bisgaard H, Chawes BL
Opublikowane w: American Journal of Respiratory and Critical care Medicine, 2021, ISSN 1073-449X
Wydawca: American Thoracic Society
DOI: 10.1164/rccm.202008-3206oc.

Urinary eicosanoid levels in early life and risk of atopic disease in childhood

Autorzy: Liang Chen, Nicklas Brustad, Min Kim, Yang Luo, Tingting Wang, Mina Ali, Nicole Prince, Yulu Chen, Su Chu, Sofina Begum, Kevin Mendez, Rachel S. Kelly, Ann-Marie Schoos, Morten A. Rasmussen, Javier Zurita, Johan Kolmert, Jakob Stokholm, Augusto Litonjua, Scott T. Weiss, Klaus Bønnelykke, Craig E. Wheelock, Jessica Lasky-Su, Bo Chawes
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 154, 2024, Strona(/y) 670-678, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2024.05.022