Dietary shaping of the early life metabolome and its role in healthy lung and brain development

Informations projet

DEFEND

N° de convention de subvention: 946228

DOI

10.3030/946228

Projet clôturé

Date de signature de la CE 29 Janvier 2021

Date de début 1 Février 2021

Date de fin 31 Janvier 2026

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 499 952,00

Contribution de l’UE

€ 1 499 952,00

Coordonné par

REGION HOVEDSTADEN
Denmark

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Publications

Peer reviewed articles (34)

The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review

Auteurs: Mette S. Schjødt; Gözde Gürdeniz; Bo L. Chawes
Publié dans: Metabolites, Numéro 1, 2020, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo10120511

Association of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life

Auteurs: Nicklas Brustad, Fink NR, Stokholm J, Bønnelykke K, Følsgaard NV, Hougaard D, Brix S, Lasky-Su J, Weiss ST, Chawes B
Publié dans: Nutrients, 2021, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14010015.

Maternal vitamin D-related metabolome and offspring risk of asthma outcomes

Auteurs: Min Kim, Nicklas Brustad, Mina Ali, Gürdeniz G, Arendt M, Litonjua AA, Wheelock CE, Kelly RS, Chen Y, Prince N, Guo F, Zhou X, Stokholm J, Bønnelykke K, Weiss ST, Bisgaard H, Lasky-Su J, Chawes B.
Publié dans: J Allergy Clin Immunol, 2023, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2023.06.030

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort

Auteurs: Sevelsted A, Pedersen CT, Gürdeniz G, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Lasky-Su J, Morin A, Ober C, Schoos AM, Stokholm J, Bønnelykke K, Bo Chawes, Bisgaard H
Publié dans: eBioMedicine, 2023, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104699

Environmental and genetic associations with aberrant early-life gut microbial maturation in childhood asthma

Auteurs: Yih-Chieh Chen; Yulu Chen; Jessica Lasky-Su; Rachel S. Kelly; Jakob Stokholm; Hans Bisgaard; Klaus Bønnelykke; Casper-Emil Tingskov Pedersen; Bo Chawes; Nancy Laranjo; Scott T. Weiss; Augusto A. Litonjua; Kathleen Lee-Sarwar
Publié dans: J Allergy Clin Immunol, Numéro 1, 2023, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2023.01.006

Maternal Diet Associates with Offspring Bone Mineralization, Fracture Risk and Enamel Defects in Childhood and Influences the Prenatal Effect of High-Dose Vitamin D Supplementation

Auteurs: Min Kim, Pia E. Nørrisgaard, Nilo Vahman, Olivier N. F. Cexus, Paul A. Townsend, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes, Nicklas Brustad
Publié dans: Nutrients, Numéro 16, 2025, Page(s) 405, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16030405

Vitamin D‐FUT2 interaction and risk of lower respiratory tract infections in childhood

Auteurs: Nicklas Brustad, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Publié dans: Allergy, Numéro 80, 2025, Page(s) 582-584, ISSN 0105-4538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/all.16266

High dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial

Auteurs: Nicklas Brustad, Chawes BL, Thorsen J, Krakauer M, Lasky-Su J, Weiss ST, Stokholm J, Bønnelykke K, Bisgaard H
Publié dans: eClinicalMedicine, 2021, ISSN 2589-5370
Éditeur: Elsevier inc.
DOI: 10.1016/j.eclinm.2021.101254

Vitamin D in early life and risk of daily registered childhood infection episodes

Auteurs: Nicklas Brustad, Julie Nyholm Kyvsgaard, Casper‐Emil Tingskov Pedersen, Laura Marie Hesselberg, Anders U. Eliasen, Signe Kjeldgaard Jensen, Luo Yang, Nilofar Vahman, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Publié dans: Allergy, Numéro 80, 2025, Page(s) 332-335, ISSN 0105-4538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/all.16354

Prenatal high-dose vitamin D supplementation and childhood atopic dermatitis until age 6 years: a secondary analysis of a randomized clinical trial

Auteurs: Nicklas Brustad, Tingting Wang, Liang Chen, Hannah Kaiser, Beatriz Gomes, Amalie Klein, Nilo Vahman, Lone Skov, Jakob Stokholm, Ann-Marie Schoos, Klaus Bønnelykke, Bo Chawes
Publié dans: British Journal of Dermatology, Numéro 193, 2025, Page(s) 775-777, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1093/bjd/ljaf208

Air pollution-induced proteomic alterations increase the risk of child respiratory infections

Auteurs: Nicklas Brustad, Tingting Wang, Shizhen He, Casper-Emil Tingskov Pedersen, Olena Gruzieva, Liang Chen, Göran Pershagen, Mina Ali, Julie Nyholm Kyvsgaard, Marie Pedersen, Matthias Ketzel, Heikki Hyöty, Daniel Agardh, Erik Melén, Jonathan Thorsen, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-61392-y

Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Auteurs: Huang M, Kelly RS, Chu SH, Kachroo P, Gürdeniz G, Chawes BL, Bisgaard H, Weiss ST, Lasky-Su J
Publié dans: Metabolites, 2021, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo11020065

Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability

Auteurs: Mario Lovrić, David Horner, Liang Chen, Nicklas Brustad, Ann-Marie Schoos, Jessica Lasky-Su, Bo Chawes, Morten Rasmussen
Publié dans: Metabolites, Numéro 14, 2025, Page(s) 136, ISSN 2218-1989
Éditeur: MDPI AG
DOI: 10.3390/metabo14030136

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

Auteurs: Sevelsted A, Gürdeniz G, Rago D, Pedersen CT, Lasky-Su JA, Checa A, Zhang P, Wheelock CE, Normann SS, Kristensen DM, Rasmussen MA, Schullehner J, Sdougkou K, Martin JW, Stokholm J, Bønnelykke K, Bisgaard H, Chawes B
Publié dans: eBioMedicine, 2022, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104236.

A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence

Auteurs: David Horner, Jens Richardt M. Jepsen, Bo Chawes, Kristina Aagaard, Julie B. Rosenberg, Parisa Mohammadzadeh, Astrid Sevelsted, Nilo Vahman, Rebecca Vinding, Birgitte Fagerlund, Christos Pantelis, Niels Bilenberg, Casper-Emil T. Pedersen, Anders Eliasen, Sarah Brandt, Yulu Chen, Nicole Prince, Su H. Chu, Rachel S. Kelly, Jessica Lasky-Su, Thorhallur I. Halldorsson, Marin Strøm, Katrine Strandberg
Publié dans: Nature Metabolism, Numéro 7, 2025, Page(s) 586-601, ISSN 2522-5812
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s42255-025-01230-z

Vertical Transfer of Metabolites Detectable from Newborn’s Dried Blood Spot Samples Using UPLC-MS: A Chemometric Study

Auteurs: Olarini A, Ernst M, Gürdeniz G, Min Kim, Nicklas Brustad, Bønnelykke K, Cohen A, Hougaard D, Lasky-Su J, Bisgaard H, Chawes B, Rasmussen MA
Publié dans: Metabolites, 2022, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo12020094.

Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts

Auteurs: Nicole Prince; Min Kim; Rachel S. Kelly; Joann Diray-Arce; Klaus Bønnelykke; Bo L. Chawes; Mengna Huang; Ofer Levy; Augusto A. Litonjua; Jakob Stokholm; Craig E. Wheelock; Hans Bisgaard; Scott T. Weiss; Jessica A. Lasky-Su
Publié dans: Metabolites, Numéro 1, 2022, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo12111108

Effects of prenatal nutrient supplementation and early life exposures on neurodevelopment at age 10: a randomised controlled trial - the COPSYCH study protocol

Auteurs: Parisa Mohammadzadeh; Julie Bøjstrup Rosenberg; Rebecca Vinding; Jens Richardt Møllegaard Jepsen; Ulrich Lindberg; Nilo Følsgaard; Mikkel Erlang Sørensen; Daban Sulaiman; Niels Bilenberg; Jayachandra Mitta Raghava; Birgitte Fagerlund; Mark Vestergaard; Christos Pantelis; Jakob Stokholm; Bo Chawes; Henrik Larsson; Birte Yding Glenthøj; Klaus Bønnelykke; Bjørn H Ebdrup; Hans Bisgaard
Publié dans: BMJ Open, Numéro 1, 2022, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-047706

Maternal dietary patterns, breastfeeding duration, and their association with child cognitive function and head circumference growth: A prospective mother–child cohort study

Auteurs: David Horner, Jens Richardt Møllegaard Jepsen, Bo Chawes, Rebecca Vinding, Julie B. Rosenberg, Parisa Mohammadzadeh, Yang Luo, Birgitte Fagerlund, Trine Flensborg-Madsen, Thomas Ragnar Wood, Janine F. Felix, Louise Monnerup, Birte Y. Glenthøj, Klaus Bønnelykke, Bjørn H. Ebdrup, Jakob Stokholm, Morten Arendt Rasmussen
Publié dans: PLOS Medicine, Numéro 22, 2025, Page(s) e1004454, ISSN 1549-1676
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/journal.pmed.1004454

Neonatal metabolome of caesarean section and risk of childhood asthma

Auteurs: Gözde Gürdeniz; Madeleine Ernst; Daniela Rago; Min Kim; Julie Courraud; Jakob Stokholm; Klaus Bønnelykke; Anders Björkbom; Urvish Trivedi; Søren J. Sørensen; Susanne Brix; David Hougaard; Morten Rasmussen; Arieh S. Cohen; Hans Bisgaard; Bo Chawes
Publié dans: European Respiratory Journal, 2022, ISSN 0903-1936
Éditeur: European Respiratory Society
DOI: 10.1183/13993003.02406-2021

Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial.

Auteurs: Lærke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo L. Chawes; Rebecca K. Vinding; Anna-Rosa Cecilie Mora-Jensen; Jonathan Thorsen; Sarah Noergaard; Bjørn H Ebdrup; Jens Richardt Møllegaard Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard
Publié dans: Child Development, 2021, ISSN 0009-3920
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13541

High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

Auteurs: Nicklas Brustad; Jens H. Greve; Hooman Mirzakhani; Casper-Emil T. Pedersen; Anders U. Eliasen; Jakob Stokholm; Jessica Lasky-Su; Klaus Bønnelykke; Augusto A. Litonjua; Scott T. Weiss; Hans Bisgaard; Bo L. Chawes
Publié dans: Pediatric Allergy and Immunology, 2021, ISSN 0905-6157
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pai.13453

25‐hydroxyvitamin D and risk of atopic diseases and infections in early childhood

Auteurs: Nicklas Brustad, Min Kim, Frederikke Skov, Ann‐Marie Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo L. Chawes
Publié dans: Allergy, Numéro 78, 2023, Page(s) 2770-2773, ISSN 0105-4538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/all.15759

Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis

Auteurs: Liang Chen, Nicklas Brustad, Yang Luo, Tingting Wang, Mina Ali, Parvaneh Ebrahimi, Ann-Marie M. Schoos, Nilo Vahman, Mario Lovrić, Morten A. Rasmussen, Johan Kolmert, Craig E. Wheelock, Jessica A. Lasky-Su, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Publié dans: JAMA Dermatology, Numéro 160, 2024, Page(s) 1082, ISSN 2168-6068
Éditeur: American Medical Association
DOI: 10.1001/jamadermatol.2024.2849

High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial

Auteurs: Kristina Aagaard, Jens Richardt Møllegaard Jepsen, Astrid Sevelsted, David Horner, Rebecca Vinding, Julie Bøjstrup Rosenberg, Nicklas Brustad, Anders Eliasen, Parisa Mohammadzadeh, Nilofar Følsgaard, María Hernández-Lorca, Birgitte Fagerlund, Birte Y. Glenthøj, Morten Arendt Rasmussen, Niels Bilenberg, Jakob Stokholm, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes
Publié dans: The American Journal of Clinical Nutrition, Numéro 119, 2025, Page(s) 362-370, ISSN 0002-9165
Éditeur: American Society for Clinical Nutrition, Inc.
DOI: 10.1016/j.ajcnut.2023.12.002

Furan fatty acid metabolite in newborns predicts risk of asthma

Auteurs: Gözde Gürdeniz; Min Kim; Nicklas Brustad; Madeleine Ernst; Francesco Russo; Jakob Stokholm; Klaus Bønnelykke; David Hougaard; Morten Rasmussen; Arieh Cohen; Bo Chawes
Publié dans: Allergy, 2022, ISSN 1398-9995
Éditeur: Wiley
DOI: 10.1111/all.15554

Diet‐associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood

Auteurs: Nicklas Brustad; Alessandra Olarini; Min Kim; Liang Chen; Mina Ali; Tingting Wang; Arieh S. Cohen; Madeleine Ernst; David Hougaard; Ann‐Marie Schoos; Jakob Stokholm; Klaus Bønnelykke; Jessica Lasky‐Su; Morten A. Rasmussen; Bo Chawes
Publié dans: Ped Allergy Immunol, Numéro 2, 2023, ISSN 1399-3038
Éditeur: Wiley
DOI: 10.1111/pai.13917

A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation

Auteurs: Mario Lovrić, Tingting Wang, Mads Rønnow Staffe, Iva Šunić, Kristina Časni, Jessica Lasky-Su, Bo Chawes, Morten Arendt Rasmussen
Publié dans: Metabolites, Numéro 14, 2025, Page(s) 278, ISSN 2218-1989
Éditeur: MDPI AG
DOI: 10.3390/metabo14050278

Elevated third trimester corticosteroid levels are associated with fewer offspring infections

Auteurs: Prince N, Kelly RS, Chu SH, Kachroo P, Chen Y, Mendez KM, Begum S, Bisgaard H, Bønnelykke K, Min Kim, Levy O, Litonjua AA, Wheelock CE, Weiss ST, Chawes B, Lasky-Su JA.
Publié dans: Sci Rep, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-36535-0

Dietary prevention strategies for childhood asthma

Auteurs: Nicklas Brustad, Klaus Bønnelykke, Bo Chawes
Publié dans: Pediatric Allergy and Immunology, Numéro 34, 2023, ISSN 0905-6157
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pai.13984

Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

Auteurs: Hanna M. Knihtilä; Rachel S. Kelly; Nicklas Brustad; Nicklas Brustad; Mengna Huang; Priyadarshini Kachroo; Bo L. Chawes; Jakob Stokholm; Klaus Bønnelykke; Casper-Emil T. Pedersen; Hans Bisgaard; Augusto A. Litonjua; Jessica Lasky-Su; Scott T. Weiss
Publié dans: European Respiratory Journal, 2021, ISSN 0903-1936
Éditeur: European Respiratory Society
DOI: 10.1183/13993003.02012-2020

Vitamin D Primary Prevention of Respiratory Infections and Asthma in Early Childhood: Evidence and Mechanisms

Auteurs: Nicklas Brustad, Bo Chawes
Publié dans: The Journal of Allergy and Clinical Immunology: In Practice, Numéro 12, 2024, Page(s) 1707-1714, ISSN 2213-2198
Éditeur: Elsevier
DOI: 10.1016/j.jaip.2024.02.005

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype.

Auteurs: Rago D, Pedersen CT, Huang M, Kelly RS, Gürdeniz G, Nicklas Brustad, Knihtil H, Lee-Sarwar KA, Morin A, Rasmussen MA, Stokholm J, Bønnelykke K, Litonjua AA, Wheelock CE, Weiss ST, Lasky-Su J, Bisgaard H, Chawes BL
Publié dans: American Journal of Respiratory and Critical care Medicine, 2021, ISSN 1073-449X
Éditeur: American Thoracic Society
DOI: 10.1164/rccm.202008-3206oc.

Urinary eicosanoid levels in early life and risk of atopic disease in childhood

Auteurs: Liang Chen, Nicklas Brustad, Min Kim, Yang Luo, Tingting Wang, Mina Ali, Nicole Prince, Yulu Chen, Su Chu, Sofina Begum, Kevin Mendez, Rachel S. Kelly, Ann-Marie Schoos, Morten A. Rasmussen, Javier Zurita, Johan Kolmert, Jakob Stokholm, Augusto Litonjua, Scott T. Weiss, Klaus Bønnelykke, Craig E. Wheelock, Jessica Lasky-Su, Bo Chawes
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 154, 2024, Page(s) 670-678, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2024.05.022