Project description
Uncovering the mechanisms that promote health during intermittent fasting
Adaptation to food deprivation is a mainstay of mammal physiology. Mammals are exquisitely fitted to tolerate frequent bouts of fasting owing to fuel production by the liver (glucose, ketones). The EU-funded MemoChrom project conjectures that mammals adapt to recurring fasting by sensitising transcriptional programmes and maximising future transcriptional responses, thereby ensuring survival. The project plans to uncover transcriptional mechanisms of fasting memory that mediate the health benefits of recurrent fasting. To this end, it will profile the hepatic transcriptome and genome-wide chromatin landscape of intermittently fasting mice. Project results could help unravel fundamental homeostatic responses and significantly advance fasting research.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting Grant
Host institution
91904 Jerusalem
Israel
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Beneficiaries (1)
91904 Jerusalem
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