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Adaptation to Recurring Fasting by Chromatin-Mediated Memory

Project description

Uncovering the mechanisms that promote health during intermittent fasting

Adaptation to food deprivation is a mainstay of mammal physiology. Mammals are exquisitely fitted to tolerate frequent bouts of fasting owing to fuel production by the liver (glucose, ketones). The EU-funded MemoChrom project conjectures that mammals adapt to recurring fasting by sensitising transcriptional programmes and maximising future transcriptional responses, thereby ensuring survival. The project plans to uncover transcriptional mechanisms of fasting memory that mediate the health benefits of recurrent fasting. To this end, it will profile the hepatic transcriptome and genome-wide chromatin landscape of intermittently fasting mice. Project results could help unravel fundamental homeostatic responses and significantly advance fasting research.

Host institution

THE HEBREW UNIVERSITY OF JERUSALEM
Net EU contribution
€ 1 500 000,00
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Net EU contribution
€ 1 500 000,00
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00