Role of epigenetic evolution in the development of tumour resistance to chemotherapy
Resistance to chemotherapy is a major challenge for the treatment of cancer, with genetic and non-genetic mechanisms contributing to drug resistance. The goal of the EU-funded ChromTrace project is to understand the contribution of epigenetic evolution to chemo-resistance in aggressive triple-negative breast cancer. The researchers will combine lineage tracing and targeted sequencing with a single-cell chromatin profiling approach to reconstruct the dynamics of chromatin features in the course of genetic evolution. Using a live-cell microscopy reporter system, they will evaluate the association of chromatin features with the resistance phenotype to elucidate the mechanisms of epigenetic tumour evolution. The ultimate goal is to apply this new knowledge for the development of therapeutic strategies to control chemo-resistance.
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