Project description
Role of epigenetic evolution in the development of tumour resistance to chemotherapy
Resistance to chemotherapy is a major challenge for the treatment of cancer, with genetic and non-genetic mechanisms contributing to drug resistance. The goal of the EU-funded ChromTrace project is to understand the contribution of epigenetic evolution to chemo-resistance in aggressive triple-negative breast cancer. The researchers will combine lineage tracing and targeted sequencing with a single-cell chromatin profiling approach to reconstruct the dynamics of chromatin features in the course of genetic evolution. Using a live-cell microscopy reporter system, they will evaluate the association of chromatin features with the resistance phenotype to elucidate the mechanisms of epigenetic tumour evolution. The ultimate goal is to apply this new knowledge for the development of therapeutic strategies to control chemo-resistance.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting Grant
Host institution
75794 Paris
France
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Beneficiaries (2)
75794 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75231 Paris
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