Depression in diverse populations: Unravelling the interplay between genes and environment

Project Information

DIVERGE

Grant agreement ID: 948561

DOI

10.3030/948561

EC signature date 13 January 2021

Start date 1 February 2021

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 495 950,00

EU contribution

€ 2 495 950,00

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Equity in cancer genomics in the UK: a cross-sectional analysis of a national cancer cohort

Author(s): T Nguyen, Sam Tallman, Yoonsu Cho, Alona Sosinsky, John Ambrose, Steve Thorn, Maxine Mackintosh, Matthew A Brown, Loukas Moutsianas, Matt J Silver, Karoline Kuchenbaecker
Published in: The Lancet Oncology, Issue 26, 2025, Page(s) 971-980, ISSN 1470-2045
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(25)00199-8

Methodological opportunities in genomic data analysis to advance health equity

Author(s): Brieuc Lehmann, Leandra Bräuninger, Yoonsu Cho, Fabian Falck, Smera Jayadeva, Michael Katell, Thuy Nguyen, Antonella Perini, Sam Tallman, Maxine Mackintosh, Matt Silver, Karoline Kuchenbäcker, David Leslie, Nilanjan Chatterjee, Chris Holmes
Published in: Nature Reviews Genetics, 2025, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-025-00839-w

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Author(s): Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss
Published in: Nature Genetics, 2024, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01596-4

Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan

Author(s): Valkovskaya M, Hassan A, Zartaloudi E, Hussain F, Umar M, Khizar B, Khattak I, Gill SA, Khan SA, Dogar IA, Mustafa AB, Ansari MA, Qalb I Hyder S, Ali M, Ilyas N, Channar P, Mughal N, Channa S, Mufti K, Mufti AA, Hussain MI, Shafiq S, Tariq M, Khan MK, Chaudhry ST, Choudhary AR, Ali MN, Ali G, Hussain A, Rehman M, Ahmad N, Farooq S, Naeem F, Nasr T, Lewis G, Knowles JA, Ayub M, Kuchenbaecker K
Published in: Psychiatric Genetics, 2023, ISSN 0955-8829
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ypg.0000000000000333

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants

Author(s): S. C. Kanjira, M. J. Adams, Y. Jiang, C. Tian, null null, C. M. Lewis, K. Kuchenbaecker, A. M. McIntosh
Published in: Molecular Psychiatry, Issue 30, 2024, Page(s) 151-157, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02662-x

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

Author(s): "Qin Qin Huang # 1 , Neneh Sallah # 2 3 , Diana Dunca 2 3 , Bhavi Trivedi 4 , Karen A Hunt 4 , Sam Hodgson 5 , Samuel A Lambert 6 7 8 , Elena Arciero 1 , John Wright 9 , Chris Griffiths 10 , Richard C Trembath 11 , Harry Hemingway 2 12 13 , Michael Inouye 6 7 8 14 15 , Sarah Finer 4 , David A van Heel 4 , R Thomas Lumbers 2 13 16 , Hilary C Martin, Karoline K"
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32095-5

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Author(s): Mark J. Adams, Fabian Streit, Xiangrui Meng, Swapnil Awasthi, Brett N. Adey, Karmel W. Choi, V. Kartik Chundru, Jonathan R.I. Coleman, Bart Ferwerda, Jerome C. Foo, Zachary F. Gerring, Olga Giannakopoulou, Priya Gupta, Alisha S.M. Hall, Arvid Harder, David M. Howard, Christopher Hübel, Alex S.F. Kwong, Daniel F. Levey, Brittany L. Mitchell, Guiyan Ni, Vanessa K. Ota, Oliver Pain, Gita A. Pathak,
Published in: Cell, Issue 188, 2025, Page(s) 640-652.e9, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.12.002

Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study

Author(s): Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49109-z

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Author(s): Mueller, Stefanie H.; Lai, Alvina G.; Valkovskaya, Maria; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Abu-Ful, Zomoruda; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baert, Thais; Freeman, Laura E.Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermi
Published in: Genome Medicine, Issue 5, 2023, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-022-01152-5

The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study

Author(s): Olga Giannakopoulou, Kuang Lin, Xiangrui Meng, Mei-Hsin Su 3 , Po-Hsiu Kuo 3 4 , Roseann E Peterson 5 , Swapnil Awasthi 6 , Arden Moscati 7 , Jonathan R I Coleman 8 9 , Nick Bass 1 , Iona Y Millwood 2 10 , Yiping Chen 2 10 , Zhengming Chen 2 10 , Hsi-Chung Chen 4 , Mong-Liang Lu 11 12 , Ming-Chyi Huang 12 13 , Chun-Hsin Chen 11 12 , Eli A Stahl 14 , Ruth J F Loos 7
Published in: JAMA Psychiatry, Issue 21686238, 2021, ISSN 2168-6238
Publisher: JAMA Network
DOI: 10.1001/jamapsychiatry.2021.2099