Depression in diverse populations: Unravelling the interplay between genes and environment

Información del proyecto

DIVERGE

Identificador del acuerdo de subvención: 948561

DOI

10.3030/948561

Fecha de la firma de la CE 13 Enero 2021

Fecha de inicio 1 Febrero 2021

Fecha de finalización 31 Enero 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 495 950,00

Aportación de la UE

€ 2 495 950,00

Coordinado por

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (10)

Equity in cancer genomics in the UK: a cross-sectional analysis of a national cancer cohort

Autores: T Nguyen, Sam Tallman, Yoonsu Cho, Alona Sosinsky, John Ambrose, Steve Thorn, Maxine Mackintosh, Matthew A Brown, Loukas Moutsianas, Matt J Silver, Karoline Kuchenbaecker
Publicado en: The Lancet Oncology, Edición 26, 2025, Página(s) 971-980, ISSN 1470-2045
Editor: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(25)00199-8

Methodological opportunities in genomic data analysis to advance health equity

Autores: Brieuc Lehmann, Leandra Bräuninger, Yoonsu Cho, Fabian Falck, Smera Jayadeva, Michael Katell, Thuy Nguyen, Antonella Perini, Sam Tallman, Maxine Mackintosh, Matt Silver, Karoline Kuchenbäcker, David Leslie, Nilanjan Chatterjee, Chris Holmes
Publicado en: Nature Reviews Genetics, 2025, ISSN 1471-0056
Editor: Nature Publishing Group
DOI: 10.1038/s41576-025-00839-w

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Autores: Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss
Publicado en: Nature Genetics, 2024, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-023-01596-4

Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan

Autores: Valkovskaya M, Hassan A, Zartaloudi E, Hussain F, Umar M, Khizar B, Khattak I, Gill SA, Khan SA, Dogar IA, Mustafa AB, Ansari MA, Qalb I Hyder S, Ali M, Ilyas N, Channar P, Mughal N, Channa S, Mufti K, Mufti AA, Hussain MI, Shafiq S, Tariq M, Khan MK, Chaudhry ST, Choudhary AR, Ali MN, Ali G, Hussain A, Rehman M, Ahmad N, Farooq S, Naeem F, Nasr T, Lewis G, Knowles JA, Ayub M, Kuchenbaecker K
Publicado en: Psychiatric Genetics, 2023, ISSN 0955-8829
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ypg.0000000000000333

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants

Autores: S. C. Kanjira, M. J. Adams, Y. Jiang, C. Tian, null null, C. M. Lewis, K. Kuchenbaecker, A. M. McIntosh
Publicado en: Molecular Psychiatry, Edición 30, 2024, Página(s) 151-157, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-024-02662-x

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

Autores: "Qin Qin Huang # 1 , Neneh Sallah # 2 3 , Diana Dunca 2 3 , Bhavi Trivedi 4 , Karen A Hunt 4 , Sam Hodgson 5 , Samuel A Lambert 6 7 8 , Elena Arciero 1 , John Wright 9 , Chris Griffiths 10 , Richard C Trembath 11 , Harry Hemingway 2 12 13 , Michael Inouye 6 7 8 14 15 , Sarah Finer 4 , David A van Heel 4 , R Thomas Lumbers 2 13 16 , Hilary C Martin, Karoline K"
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32095-5

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Autores: Mark J. Adams, Fabian Streit, Xiangrui Meng, Swapnil Awasthi, Brett N. Adey, Karmel W. Choi, V. Kartik Chundru, Jonathan R.I. Coleman, Bart Ferwerda, Jerome C. Foo, Zachary F. Gerring, Olga Giannakopoulou, Priya Gupta, Alisha S.M. Hall, Arvid Harder, David M. Howard, Christopher Hübel, Alex S.F. Kwong, Daniel F. Levey, Brittany L. Mitchell, Guiyan Ni, Vanessa K. Ota, Oliver Pain, Gita A. Pathak,
Publicado en: Cell, Edición 188, 2025, Página(s) 640-652.e9, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2024.12.002

Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study

Autores: Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-49109-z

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Autores: Mueller, Stefanie H.; Lai, Alvina G.; Valkovskaya, Maria; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Abu-Ful, Zomoruda; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baert, Thais; Freeman, Laura E.Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermi
Publicado en: Genome Medicine, Edición 5, 2023, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-022-01152-5

The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study

Autores: Olga Giannakopoulou, Kuang Lin, Xiangrui Meng, Mei-Hsin Su 3 , Po-Hsiu Kuo 3 4 , Roseann E Peterson 5 , Swapnil Awasthi 6 , Arden Moscati 7 , Jonathan R I Coleman 8 9 , Nick Bass 1 , Iona Y Millwood 2 10 , Yiping Chen 2 10 , Zhengming Chen 2 10 , Hsi-Chung Chen 4 , Mong-Liang Lu 11 12 , Ming-Chyi Huang 12 13 , Chun-Hsin Chen 11 12 , Eli A Stahl 14 , Ruth J F Loos 7
Publicado en: JAMA Psychiatry, Edición 21686238, 2021, ISSN 2168-6238
Editor: JAMA Network
DOI: 10.1001/jamapsychiatry.2021.2099