Depression in diverse populations: Unravelling the interplay between genes and environment

Informazioni relative al progetto

DIVERGE

ID dell’accordo di sovvenzione: 948561

DOI

10.3030/948561

Data della firma CE 13 Gennaio 2021

Data di avvio 1 Febbraio 2021

Data di completamento 31 Gennaio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 495 950,00

Contributo UE

€ 2 495 950,00

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (10)

Equity in cancer genomics in the UK: a cross-sectional analysis of a national cancer cohort

Autori: T Nguyen, Sam Tallman, Yoonsu Cho, Alona Sosinsky, John Ambrose, Steve Thorn, Maxine Mackintosh, Matthew A Brown, Loukas Moutsianas, Matt J Silver, Karoline Kuchenbaecker
Pubblicato in: The Lancet Oncology, Numero 26, 2025, Pagina/e 971-980, ISSN 1470-2045
Editore: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(25)00199-8

Methodological opportunities in genomic data analysis to advance health equity

Autori: Brieuc Lehmann, Leandra Bräuninger, Yoonsu Cho, Fabian Falck, Smera Jayadeva, Michael Katell, Thuy Nguyen, Antonella Perini, Sam Tallman, Maxine Mackintosh, Matt Silver, Karoline Kuchenbäcker, David Leslie, Nilanjan Chatterjee, Chris Holmes
Pubblicato in: Nature Reviews Genetics, 2025, ISSN 1471-0056
Editore: Nature Publishing Group
DOI: 10.1038/s41576-025-00839-w

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Autori: Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss
Pubblicato in: Nature Genetics, 2024, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-023-01596-4

Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan

Autori: Valkovskaya M, Hassan A, Zartaloudi E, Hussain F, Umar M, Khizar B, Khattak I, Gill SA, Khan SA, Dogar IA, Mustafa AB, Ansari MA, Qalb I Hyder S, Ali M, Ilyas N, Channar P, Mughal N, Channa S, Mufti K, Mufti AA, Hussain MI, Shafiq S, Tariq M, Khan MK, Chaudhry ST, Choudhary AR, Ali MN, Ali G, Hussain A, Rehman M, Ahmad N, Farooq S, Naeem F, Nasr T, Lewis G, Knowles JA, Ayub M, Kuchenbaecker K
Pubblicato in: Psychiatric Genetics, 2023, ISSN 0955-8829
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ypg.0000000000000333

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants

Autori: S. C. Kanjira, M. J. Adams, Y. Jiang, C. Tian, null null, C. M. Lewis, K. Kuchenbaecker, A. M. McIntosh
Pubblicato in: Molecular Psychiatry, Numero 30, 2024, Pagina/e 151-157, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02662-x

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

Autori: "Qin Qin Huang # 1 , Neneh Sallah # 2 3 , Diana Dunca 2 3 , Bhavi Trivedi 4 , Karen A Hunt 4 , Sam Hodgson 5 , Samuel A Lambert 6 7 8 , Elena Arciero 1 , John Wright 9 , Chris Griffiths 10 , Richard C Trembath 11 , Harry Hemingway 2 12 13 , Michael Inouye 6 7 8 14 15 , Sarah Finer 4 , David A van Heel 4 , R Thomas Lumbers 2 13 16 , Hilary C Martin, Karoline K"
Pubblicato in: Nature Communications, Numero 20411723, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32095-5

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Autori: Mark J. Adams, Fabian Streit, Xiangrui Meng, Swapnil Awasthi, Brett N. Adey, Karmel W. Choi, V. Kartik Chundru, Jonathan R.I. Coleman, Bart Ferwerda, Jerome C. Foo, Zachary F. Gerring, Olga Giannakopoulou, Priya Gupta, Alisha S.M. Hall, Arvid Harder, David M. Howard, Christopher Hübel, Alex S.F. Kwong, Daniel F. Levey, Brittany L. Mitchell, Guiyan Ni, Vanessa K. Ota, Oliver Pain, Gita A. Pathak,
Pubblicato in: Cell, Numero 188, 2025, Pagina/e 640-652.e9, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2024.12.002

Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study

Autori: Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-49109-z

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Autori: Mueller, Stefanie H.; Lai, Alvina G.; Valkovskaya, Maria; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Abu-Ful, Zomoruda; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baert, Thais; Freeman, Laura E.Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermi
Pubblicato in: Genome Medicine, Numero 5, 2023, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-022-01152-5

The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study

Autori: Olga Giannakopoulou, Kuang Lin, Xiangrui Meng, Mei-Hsin Su 3 , Po-Hsiu Kuo 3 4 , Roseann E Peterson 5 , Swapnil Awasthi 6 , Arden Moscati 7 , Jonathan R I Coleman 8 9 , Nick Bass 1 , Iona Y Millwood 2 10 , Yiping Chen 2 10 , Zhengming Chen 2 10 , Hsi-Chung Chen 4 , Mong-Liang Lu 11 12 , Ming-Chyi Huang 12 13 , Chun-Hsin Chen 11 12 , Eli A Stahl 14 , Ruth J F Loos 7
Pubblicato in: JAMA Psychiatry, Numero 21686238, 2021, ISSN 2168-6238
Editore: JAMA Network
DOI: 10.1001/jamapsychiatry.2021.2099