Rejuvenating and ageing blood factors as therapeutic targets for Alzheimer's disease
Ageing is the most critical risk factor for Alzheimer's disease (AD). The EU-funded HeBe project aims to discover blood factors with a rejuvenating or ageing effect on the human brain for the development of therapeutic targets for AD. The hypothesis is that higher levels of rejuvenating blood factors decrease the rate of neurodegeneration, whereas higher levels of ageing blood factors increase it. The study will define extreme biological age phenotypes in women and men based on the difference between biological and chronological age. It will use proteomics and metabolomics to identify blood factors that differ between these extreme phenotypes and develop assays to measure these factors in longitudinal cohorts of cognitively unimpaired and preclinical AD individuals.
Fields of science
Funding SchemeERC-STG - Starting Grant
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