Identification of age-related Human Blood factors as a therapeutic target for Alzheimer's disease

Project Information

HeBe

Grant agreement ID: 948677

DOI 10.3030/948677

EC signature date 10 November 2020

Start date 1 April 2021

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 498 915,00

EU contribution € 1 498 915,00

Coordinated by

FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER
Spain

Publications

Peer reviewed articles (9)

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum.

Author(s): Andrea Lessa Benedet; Andrea Lessa Benedet; Marta Milà-Alomà; Agathe Vrillon; Agathe Vrillon; Nicholas J. Ashton; Tharick A. Pascoal; Firoza Z. Lussier; Thomas K. Karikari; Claire Hourregue; Emmanuel Cognat; Julien Dumurgier; Jenna Stevenson; Nesrine Rahmouni; Vanessa Pallen; Nina Margherita Poltronetti; Gemma Salvadó; Mahnaz Shekari; Mahnaz Shekari; Gregory Operto; Juan Domingo Gispert; Caroli
Published in: JAMA Neurology, Issue 1, 2021, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2021.3671

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease

Author(s): Milà-Alomà M, Ashton NJ, Shekari M, Salvadó G, Ortiz-Romero P, Montoliu-Gaya L, Benedet AL, Karikari TK, Lantero-Rodriguez J, Vanmechelen E, Day TA, González-Escalante A, Sánchez-Benavides G, Minguillon C, Fauria K, Molinuevo JL, Dage JL, Zetterberg H, Gispert JD, Suárez-Calvet M, Blennow K.
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-01925-w

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile.

Author(s): Marta Milà-Alomà; Mahnaz Shekari; Mahnaz Shekari; Gemma Salvadó; Juan Domingo Gispert; Eider M de Arenaza-Urquijo; Grégory Operto; Carles Falcon; Natalia Vilor-Tejedor; Oriol Grau-Rivera; Aleix Sala-Vila; Gonzalo Sánchez-Benavides; José Maria González-de-Echávarri; Carolina Minguillon; Karine Fauria; Aida Niñerola-Baizán; Andrés Perissinotti; Maryline Simon; Gwendlyn Kollmorgen; Henrik
Published in: Alzheimer's Research and Therapy, 13(1):134. BioMed Central Ltd., Issue 1, 2021, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-021-00863-y

Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays

Author(s): Ashton NJ, Puig-Pijoan A, Milà-Alomà M, Fernández-Lebrero A, García-Escobar G, González-Ortiz F, Kac PR, Brum WS, Benedet AL, Lantero-Rodriguez J, Day TA, Vanbrabant J, Stoops E, Vanmechelen E, Triana-Baltzer G, Moughadam S, Kolb H, Ortiz-Romero P, Karikari TK, Minguillon C, Hernández Sánchez JJ, Navalpotro-Gómez I, Grau-Rivera O, María Manero R, Puente-Periz V, de la Torre R, Roquer J, D
Published in: Alzheimer's & dementia, 2023, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.12841

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation

Author(s): Cacciaglia, Raffaele; Operto, Grégory; Falcón, Carles; González de Echávarri, José Maria; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Milà Alomà, Marta; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA study
Published in: Cerebral Cortex, Issue 1, 2022, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhac239

P-tau235: a novel biomarker for staging preclinical Alzheimer's disease.

Author(s): Juan Lantero-Rodriguez; Anniina Snellman; Anniina Snellman; Andrea Lessa Benedet; Andrea Lessa Benedet; Marta Milà-Alomà; Elena Camporesi; Laia Montoliu-Gaya; Nicholas J. Ashton; Agathe Vrillon; Thomas K Karikari; Thomas K Karikari; Juan Domingo Gispert; Gemma Salvadó; Mahnaz Shekari; Christina E. Toomey; T. Lashley; Henrik Zetterberg; Marc Suárez-Calvet; Gunnar Brinkmalm; Pedro Rosa Neto; Ped
Published in: EMBO Molecular Medicine, Vol 13, Iss 12, Pp n/a-n/a (2021), Issue 2, 2021, ISSN 1757-4684
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA
DOI: 10.15252/emmm.202115098

Biological brain age prediction using machine learning on structural neuroimaging data: multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex

Author(s): Cumplido-Mayoral I, García-Prat M, Operto G, Falcon C, Shekari M, Cacciaglia R, Milà-Alomà M, Lorenzini L, Ingala S, Meije Wink A, Mutsaerts HJMM, Minguillón C, Fauria K, Molinuevo JL, Haller S, Chetelat G, Waldman A, Schwarz AJ, Barkhof F, Suridjan I, Kollmorgen G, Bayfield A, Zetterberg H, Blennow K, Suárez-Calvet M, Vilaplana V, Gispert López JD
Published in: Elife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.81067

An international overview

Author(s): Constance Delaby; Charlotte E. Teunissen; Kaj Blennow; Daniel Alcolea; Ivan Arisi; Elodie Bouaziz Amar; Anne Beaume; Aurélie Bedel; Giovanni Bellomo; Edith Bigot‐Corbel; Maria Bjerke; Marie‐Céline Blanc‐Quintin; Mercè Boada; Olivier Bousiges; Miles D Chapman; Mari L. DeMarco; Mara D'Onofrio; Julien Dumurgier; Diane Dufour‐Rainfray; Sebastiaan Engelborghs; Hermann Esselmann; Anne Fogli;
Published in: Alzheimer's & dementia, Issue 1, 2021, ISSN 1552-5279
Publisher: Wiley
DOI: 10.1002/alz.12545

CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET

Author(s): Milà-Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Gispert, Juan Domingo; Vilor-Tejedor, Natalia; Arenaza-Urquijo, Eider M.; Grau-Rivera, Oriol; Sala-Vila, Aleix; Sanchez-Benavides, Gonzalo; González-de-Echávarri, José María; Minguillon, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti,
Published in: Neurology, Issue 2, 2021, Page(s) e2065-e2078, ISSN 1662-680X
Publisher: S. Karger AG
DOI: 10.1212/wnl.0000000000012853