Identification of age-related Human Blood factors as a therapeutic target for Alzheimer's disease

Informazioni relative al progetto

HeBe

ID dell’accordo di sovvenzione: 948677

DOI

10.3030/948677

Progetto chiuso

Data della firma CE 10 Novembre 2020

Data di avvio 1 Aprile 2021

Data di completamento 31 Marzo 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 498 915,00

Contributo UE

€ 1 498 915,00

Coordinato da

FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (18)

A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer’s disease

Autori: Armand González-Escalante, Marta Milà-Alomà, Wagner S. Brum, Nicholas J. Ashton, Paula Ortiz-Romero, Mahnaz Shekari, Marta del Campo, Federica Anastasi, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Carolina Minguillón, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Juan Domingo Gispert, Henrik Zetterberg, Natalia Vilor-Tejedor, Kaj Blennow, Marc Suárez-Calvet
Pubblicato in: eBioMedicine, Numero 116, 2026, Pagina/e 105741, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105741

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum.

Autori: Andrea Lessa Benedet; Andrea Lessa Benedet; Marta Milà-Alomà; Agathe Vrillon; Agathe Vrillon; Nicholas J. Ashton; Tharick A. Pascoal; Firoza Z. Lussier; Thomas K. Karikari; Claire Hourregue; Emmanuel Cognat; Julien Dumurgier; Jenna Stevenson; Nesrine Rahmouni; Vanessa Pallen; Nina Margherita Poltronetti; Gemma Salvadó; Mahnaz Shekari; Mahnaz Shekari; Gregory Operto; Juan Domingo Gispert; Caroli
Pubblicato in: JAMA Neurology, Numero 1, 2021, ISSN 2168-6149
Editore: American Medical Association
DOI: 10.1001/jamaneurol.2021.3671

CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease

Autori: Noëlle Warmenhoven, Gonzalo Sánchez‐Benavides, Armand González‐Escalante, Marta Milà‐Alomà, Mahnaz Shekari, David López‐Martos, Paula Ortiz‐Romero, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carolina Minguillón, Juan Domingo Gispert, Natalia Vilor‐Tejedor, Eider Arenaza‐Urquijo, Eleni Palpatzis, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Marc Suárez‐Calvet, Oriol G
Pubblicato in: Alzheimer's & Dementia, Numero 20, 2025, Pagina/e 5819-5832, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.13862

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease

Autori: Milà-Alomà M, Ashton NJ, Shekari M, Salvadó G, Ortiz-Romero P, Montoliu-Gaya L, Benedet AL, Karikari TK, Lantero-Rodriguez J, Vanmechelen E, Day TA, González-Escalante A, Sánchez-Benavides G, Minguillon C, Fauria K, Molinuevo JL, Dage JL, Zetterberg H, Gispert JD, Suárez-Calvet M, Blennow K.
Pubblicato in: Nature Medicine, 2022, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-022-01925-w

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile.

Autori: Marta Milà-Alomà; Mahnaz Shekari; Mahnaz Shekari; Gemma Salvadó; Juan Domingo Gispert; Eider M de Arenaza-Urquijo; Grégory Operto; Carles Falcon; Natalia Vilor-Tejedor; Oriol Grau-Rivera; Aleix Sala-Vila; Gonzalo Sánchez-Benavides; José Maria González-de-Echávarri; Carolina Minguillon; Karine Fauria; Aida Niñerola-Baizán; Andrés Perissinotti; Maryline Simon; Gwendlyn Kollmorgen; Henrik
Pubblicato in: Alzheimer's Research and Therapy, 13(1):134. BioMed Central Ltd., Numero 1, 2021, ISSN 1758-9193
Editore: BioMed Central
DOI: 10.1186/s13195-021-00863-y

The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study

Autori: Irene Cumplido-Mayoral, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Armand González-Escalante, Federica Anastasi, Marta Milà-Alomà, David López-Martos, Muge Akinci, Carles Falcón, Mahnaz Shekari, Raffaele Cacciaglia, Eider M Arenaza-Urquijo, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Marc Suárez-Calvet, Oriol Grau-Rivera, Verónica Vilaplana, Juan Domingo Gispert, R AQU
Pubblicato in: The Lancet Healthy Longevity, Numero 5, 2026, Pagina/e e276-e286, ISSN 2666-7568
Editore: Elsevier BV
DOI: 10.1016/s2666-7568(24)00025-4

Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays

Autori: Ashton NJ, Puig-Pijoan A, Milà-Alomà M, Fernández-Lebrero A, García-Escobar G, González-Ortiz F, Kac PR, Brum WS, Benedet AL, Lantero-Rodriguez J, Day TA, Vanbrabant J, Stoops E, Vanmechelen E, Triana-Baltzer G, Moughadam S, Kolb H, Ortiz-Romero P, Karikari TK, Minguillon C, Hernández Sánchez JJ, Navalpotro-Gómez I, Grau-Rivera O, María Manero R, Puente-Periz V, de la Torre R, Roquer J, D
Pubblicato in: Alzheimer's & dementia, 2023, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12841

Enhanced proteome profiling of human cerebrospinal fluid using a commercial plasma enrichment strategy

Autori: Eva Borràs, Federica Anastasi, Olga Pastor, Marc Suárez-Calvet, Eduard Sabidó
Pubblicato in: Journal of Proteomics, Numero 324, 2026, Pagina/e 105575, ISSN 1874-3919
Editore: Elsevier BV
DOI: 10.1016/j.jprot.2025.105575

Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers

Autori: Irene Cumplido-Mayoral, Gonzalo Sánchez-Benavides, Natalia Vilor-Tejedor, David López-Martos, Anna Brugulat-Serrat, Marta Milà-Alomà, Carles Falcon, Raffaele Cacciaglia, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Clara Quijano-Rubio, José Luis Molinuevo, Oriol Grau-Rivera, Marc Suárez-Calvet, Verónica Vilaplana, Juan Domingo Gispert, null null, null null
Pubblicato in: Molecular Psychiatry, Numero 30, 2025, Pagina/e 3718-3728, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-025-02961-x

Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform

Autori: Sebastian Palmqvist, Noëlle Warmenhoven, Federica Anastasi, Andrea Pilotto, Shorena Janelidze, Pontus Tideman, Erik Stomrud, Niklas Mattsson-Carlgren, Ruben Smith, Rik Ossenkoppele, Kübra Tan, Anna Dittrich, Ingmar Skoog, Henrik Zetterberg, Virginia Quaresima, Chiara Tolassi, Kina Höglund, Duilio Brugnoni, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Alessandro Padovani, Mark Mo
Pubblicato in: Nature Medicine, Numero 31, 2026, Pagina/e 2036-2043, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-025-03622-w

Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance

Autori: Federica Anastasi, Patricia Genius, Blanca Rodriguez-Fernandez, Chengran Yang, Priyanka Gorijala, Jigyasha Timsina, Felipe Hernández-Villamizar, Luigi Lorenzini, Marta del Campo, Gonzalo Sánchez-Benavides, Carolina Minguillon, Arcadi Navarro, Carlos Cruchaga, Marc Suárez-Calvet, Natalia Vilor-Tejedor
Pubblicato in: Neurobiology of Aging, Numero 157, 2026, Pagina/e 68-78, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2025.10.003

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation

Autori: Cacciaglia, Raffaele; Operto, Grégory; Falcón, Carles; González de Echávarri, José Maria; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Milà Alomà, Marta; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA study
Pubblicato in: Cerebral Cortex, Numero 1, 2022, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhac239

A head‐to‐head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic

Autori: Federica Anastasi, Aida Fernández‐Lebrero, Nicholas J. Ashton, Paula Ortiz‐Romero, Javier Torres‐Torronteras, Armand González‐Escalante, Marta Milà‐Alomà, José Contador, Greta García‐Escobar, Rosa María Manero‐Borràs, Irene Navalpotro‐Gómez, Esther Jiménez‐Moyano, Aparna Sahajan, Qinyu Hao, Bingqing Zhang, Andreas Jeromin, Nathalie Le Bastard, Alicia Nadal, Tahmine Mous
Pubblicato in: Alzheimer's & Dementia, Numero 21, 2026, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.14609

P-tau235: a novel biomarker for staging preclinical Alzheimer's disease.

Autori: Juan Lantero-Rodriguez; Anniina Snellman; Anniina Snellman; Andrea Lessa Benedet; Andrea Lessa Benedet; Marta Milà-Alomà; Elena Camporesi; Laia Montoliu-Gaya; Nicholas J. Ashton; Agathe Vrillon; Thomas K Karikari; Thomas K Karikari; Juan Domingo Gispert; Gemma Salvadó; Mahnaz Shekari; Christina E. Toomey; T. Lashley; Henrik Zetterberg; Marc Suárez-Calvet; Gunnar Brinkmalm; Pedro Rosa Neto; Ped
Pubblicato in: EMBO Molecular Medicine, Vol 13, Iss 12, Pp n/a-n/a (2021), Numero 2, 2021, ISSN 1757-4684
Editore: WILEY-VCH Verlag GmbH & Co. KGaA
DOI: 10.15252/emmm.202115098

Biological brain age prediction using machine learning on structural neuroimaging data: multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex

Autori: Cumplido-Mayoral I, García-Prat M, Operto G, Falcon C, Shekari M, Cacciaglia R, Milà-Alomà M, Lorenzini L, Ingala S, Meije Wink A, Mutsaerts HJMM, Minguillón C, Fauria K, Molinuevo JL, Haller S, Chetelat G, Waldman A, Schwarz AJ, Barkhof F, Suridjan I, Kollmorgen G, Bayfield A, Zetterberg H, Blennow K, Suárez-Calvet M, Vilaplana V, Gispert López JD
Pubblicato in: Elife, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.81067

An international overview

Autori: Constance Delaby; Charlotte E. Teunissen; Kaj Blennow; Daniel Alcolea; Ivan Arisi; Elodie Bouaziz Amar; Anne Beaume; Aurélie Bedel; Giovanni Bellomo; Edith Bigot‐Corbel; Maria Bjerke; Marie‐Céline Blanc‐Quintin; Mercè Boada; Olivier Bousiges; Miles D Chapman; Mari L. DeMarco; Mara D'Onofrio; Julien Dumurgier; Diane Dufour‐Rainfray; Sebastiaan Engelborghs; Hermann Esselmann; Anne Fogli;
Pubblicato in: Alzheimer's & dementia, Numero 1, 2021, ISSN 1552-5279
Editore: Wiley
DOI: 10.1002/alz.12545

The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging

Autori: Farhad Imam, Rowan Saloner, Jacob W. Vogel, Varsha Krish, Gamal Abdel-Azim, Muhammad Ali, Lijun An, Federica Anastasi, David Bennett, Alexa Pichet Binette, Adam L. Boxer, Martin Bringmann, Jeffrey M. Burns, Carlos Cruchaga, Jeff L. Dage, Amelia Farinas, Luigi Ferrucci, Caitlin A. Finney, Mark Frasier, Oskar Hansson, Timothy J. Hohman, Erik C. B. Johnson, Mika Kivimaki, Roxanna Korologou-Linden, Ag
Pubblicato in: Nature Medicine, Numero 31, 2025, Pagina/e 2556-2566, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-025-03834-0

CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET

Autori: Milà-Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Gispert, Juan Domingo; Vilor-Tejedor, Natalia; Arenaza-Urquijo, Eider M.; Grau-Rivera, Oriol; Sala-Vila, Aleix; Sanchez-Benavides, Gonzalo; González-de-Echávarri, José María; Minguillon, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti,
Pubblicato in: Neurology, Numero 2, 2021, Pagina/e e2065-e2078, ISSN 1662-680X
Editore: S. Karger AG
DOI: 10.1212/wnl.0000000000012853