Deciphering and Engineering the overlooked but Universal phenomenon of Subpopulations in BIOtechnology

Project Information

DEUSBIO

Grant agreement ID: 949080

DOI 10.3030/949080

EC signature date 9 October 2020

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 998,00

EU contribution € 1 499 998,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Publications

Peer reviewed articles (10)

Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

Author(s): Jiang, Wei; Hernandez Villamor, David; Peng, Huadong; Chen, Jian; Liu, Long; Haritos, Victoria; Ledesma-Amaro, Rodrigo
Published in: Nature Chemical Biology, 2022, ISSN 1552-4469
Publisher: Nature
DOI: 10.1038/s41589-021-00836-0

A molecular toolkit of cross-feeding strains for engineering synthetic yeast communities

Author(s): Peng, H., Darlington, A.P.S., South, E.J. et al. Rodrigo Ledesma-Amaro
Published in: Nature Microbiology, 2024, ISSN 2058-5276
Publisher: Nature
DOI: 10.1038/s41564-023-01596-4

Division of labor for substrate utilization in natural and synthetic microbial communities

Author(s): Razieh Rafieenia; Eliza Atkinson; Rodrigo Ledesma-Amaro
Published in: Current opinion in Biotechnology, Issue 09581669, 2022, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2022.102706

Resource-aware whole-cell model of division of labour in a microbial consortium for complex-substrate degradation

Author(s): Ledesma Amaro, R; Stan, G-B; Atkinson, E; Perrino, G; Tuza, Z
Published in: Microbial cell factories, Issue 14752859, 2022, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-022-01842-0

Inducible expression of large gRNA arrays for multiplexed CRISPRai applications

Author(s): Shaw, W.M., Studená, L., Roy, K. et al.
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32603-7

New synthetic biology tools for metabolic control

Author(s): Xueqin Lv, Angeles Hueso-Gil, Xinyu Bi, Yaokang Wu, Yanfeng Liu, Long Liu, RodrigoLedesma-Amaro
Published in: Current opinion in Biotechnology, Issue 09581669, 2022, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2022.102724

Modular Metabolic Engineering and Synthetic Coculture Strategies for the Production of Aromatic Compounds in Yeast

Author(s): Huadong Peng; Ruiqi Chen; William M. Shaw; Piotr Hapeta; Wei Jiang; David J. Bell; Tom Ellis; Rodrigo Ledesma-Amaro
Published in: ACS synthetic Biology, Issue 9, 2023, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.3c00047

Spontaneously established syntrophic yeast communities improve bioproduction

Author(s): "Simran Kaur Aulakh # 1 2 , Lara Sellés Vidal # 3 , Eric J South # 3 , Huadong Peng 3 , Sreejith Jayasree Varma 4 , Lucia Herrera-Dominguez 1 4 , Markus Ralser 5 6 7 8 , Rodrigo Ledesma-Amaro 9"
Published in: Nature Chemical Biology, 2023, ISSN 1552-4469
Publisher: Nature
DOI: 10.1038/s41589-023-01341-2

What makes Yarrowia lipolytica well suited for industry?

Author(s): Young-KyoungPark, RodrigoLedesma-Amaro
Published in: Trends in Biotechnology, Issue 18793096, 2022, ISSN 1879-3096
Publisher: Cell Press
DOI: 10.1016/j.tibtech.2022.07.006

Synthetic biology and bioelectrochemical tools for electrogenetic system engineering

Author(s): Joshua M. Lawrence, et al [...]Rodrigo Ledesma-Amaro
Published in: Science Advances, Issue 23752548, 2022, ISSN 2375-2548
Publisher: Sciences Advanced
DOI: 10.1126/sciadv.abm5091