Deciphering and Engineering the overlooked but Universal phenomenon of Subpopulations in BIOtechnology

Información del proyecto

DEUSBIO

Identificador del acuerdo de subvención: 949080

DOI

10.3030/949080

Fecha de la firma de la CE 9 Octubre 2020

Fecha de inicio 1 Marzo 2021

Fecha de finalización 28 Febrero 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 998,00

Aportación de la UE

€ 1 499 998,00

Coordinado por

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (26)

<i>Vibrio natriegens</i> genome‐scale modeling reveals insights into halophilic adaptations and resource allocation

Autores: Lucas Coppens, Tanya Tschirhart, Dagmar H Leary, Sophie M Colston, Jaimee R Compton, William Judson Hervey, Karl L Dana, Gary J Vora, Sergio Bordel, Rodrigo Ledesma‐Amaro
Publicado en: Molecular Systems Biology, Edición 19, 2023, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.202110523

The microbial food revolution

Autores: Alicia E. Graham, Rodrigo Ledesma-Amaro
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-37891-1

Microbial conversion of ethanol to high-value products: progress and challenges

Autores: Manman Sun, Alex Xiong Gao, Xiuxia Liu, Zhonghu Bai, Peng Wang, Rodrigo Ledesma-Amaro
Publicado en: Biotechnology for Biofuels and Bioproducts, Edición 17, 2024, ISSN 2731-3654
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13068-024-02546-w

Synthetic, marine, light-driven, autotroph-heterotroph co-culture system for sustainable β-caryophyllene production

Autores: Wenchao Chen, Young-Kyoung Park, Lucie Studená, David Bell, Piotr Hapeta, Jing Fu, Peter J. Nixon, Rodrigo Ledesma-Amaro
Publicado en: Bioresource Technology, Edición 410, 2024, Página(s) 131232, ISSN 0960-8524
Editor: Elsevier BV
DOI: 10.1016/j.biortech.2024.131232

Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

Autores: Jiang, Wei; Hernandez Villamor, David; Peng, Huadong; Chen, Jian; Liu, Long; Haritos, Victoria; Ledesma-Amaro, Rodrigo
Publicado en: Nature Chemical Biology, 2022, ISSN 1552-4469
Editor: Nature
DOI: 10.1038/s41589-021-00836-0

Fusarium-based mycoprotein: Advancements in the production of sustainable meat substitutes

Autores: Rima Gnaim, Paul S. Dyer, Rodrigo Ledesma-Amaro
Publicado en: Trends in Food Science &amp; Technology, Edición 159, 2025, Página(s) 104981, ISSN 0924-2244
Editor: Elsevier BV
DOI: 10.1016/j.tifs.2025.104981

Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity

Autores: Kiyan Shabestary, Cinzia Klemm, Benedict Carling, James Marshall, Juline Savigny, Marko Storch, Rodrigo Ledesma-Amaro
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-50602-8

A molecular toolkit of cross-feeding strains for engineering synthetic yeast communities

Autores: Peng, H., Darlington, A.P.S., South, E.J. et al. Rodrigo Ledesma-Amaro
Publicado en: Nature Microbiology, 2024, ISSN 2058-5276
Editor: Nature
DOI: 10.1038/s41564-023-01596-4

Advances in the biosynthesis of β-carotene and its derivatives in yeast

Autores: Tingan Zhou, Young-Kyoung Park, Rodrigo Ledesma-Amaro
Publicado en: Bioresource Technology, Edición 435, 2025, Página(s) 132936, ISSN 0960-8524
Editor: Elsevier BV
DOI: 10.1016/j.biortech.2025.132936

DELLA proteins recruit the Mediator complex subunit MED15 to coactivate transcription in land plants

Autores: Jorge Hernández-García, Antonio Serrano-Mislata, María Lozano-Quiles, Cristina Úrbez, María A. Nohales, Noel Blanco-Touriñán, Huadong Peng, Rodrigo Ledesma-Amaro, Miguel A. Blázquez
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2319163121

Designing synthetic microbial communities with the capacity to upcycle fermentation byproducts to increase production yields

Autores: Razieh Rafieenia, Cinzia Klemm, Piotr Hapeta, Jing Fu, María Gallego García, Rodrigo Ledesma-Amaro
Publicado en: Trends in Biotechnology, Edición 43, 2025, Página(s) 601-619, ISSN 0167-7799
Editor: Elsevier BV
DOI: 10.1016/j.tibtech.2024.10.015

Synthetic biology of Fusarium for the sustainable production of valuable bioproducts

Autores: Rima Gnaim, Rodrigo Ledesma-Amaro
Publicado en: Biotechnology Advances, Edición 81, 2025, Página(s) 108579, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2025.108579

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

Autores: Dingrong Kang, Saeed Shoaie, Samuel Jacquiod, Søren J. Sørensen, Rodrigo Ledesma-Amaro
Publicado en: Microorganisms, Edición 9, 2025, Página(s) 1042, ISSN 2076-2607
Editor: MDPI AG
DOI: 10.3390/microorganisms9051042

Division of labor for substrate utilization in natural and synthetic microbial communities

Autores: Razieh Rafieenia; Eliza Atkinson; Rodrigo Ledesma-Amaro
Publicado en: Current opinion in Biotechnology, Edición 09581669, 2022, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2022.102706

Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin

Autores: Tingan Zhou, Young-Kyoung Park, Jing Fu, Piotr Hapeta, Cinzia Klemm, Rodrigo Ledesma-Amaro
Publicado en: Biotechnology for Biofuels and Bioproducts, Edición 18, 2025, ISSN 2731-3654
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13068-024-02598-y

Resource-aware whole-cell model of division of labour in a microbial consortium for complex-substrate degradation

Autores: Ledesma Amaro, R; Stan, G-B; Atkinson, E; Perrino, G; Tuza, Z
Publicado en: Microbial cell factories, Edición 14752859, 2022, ISSN 1475-2859
Editor: BioMed Central
DOI: 10.1186/s12934-022-01842-0

Inducible expression of large gRNA arrays for multiplexed CRISPRai applications

Autores: Shaw, W.M., Studená, L., Roy, K. et al.
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32603-7

New synthetic biology tools for metabolic control

Autores: Xueqin Lv, Angeles Hueso-Gil, Xinyu Bi, Yaokang Wu, Yanfeng Liu, Long Liu, RodrigoLedesma-Amaro
Publicado en: Current opinion in Biotechnology, Edición 09581669, 2022, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2022.102724

Engineered cross-feeding creates inter- and intra-species synthetic yeast communities with enhanced bioproduction

Autores: Young-Kyoung Park, Huadong Peng, Piotr Hapeta, Lara Sellés Vidal, Rodrigo Ledesma-Amaro
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-53117-4

Modular Metabolic Engineering and Synthetic Coculture Strategies for the Production of Aromatic Compounds in Yeast

Autores: Huadong Peng; Ruiqi Chen; William M. Shaw; Piotr Hapeta; Wei Jiang; David J. Bell; Tom Ellis; Rodrigo Ledesma-Amaro
Publicado en: ACS synthetic Biology, Edición 9, 2023, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.3c00047

Efficient synthesis of limonene production in Yarrowia lipolytica by combinatorial engineering strategies

Autores: Young-Kyoung Park, Lara Sellés Vidal, David Bell, Jure Zabret, Mladen Soldat, Martin Kavšček, Rodrigo Ledesma-Amaro
Publicado en: Biotechnology for Biofuels and Bioproducts, Edición 17, 2024, ISSN 2731-3654
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13068-024-02535-z

Spontaneously established syntrophic yeast communities improve bioproduction

Autores: "Simran Kaur Aulakh # 1 2 , Lara Sellés Vidal # 3 , Eric J South # 3 , Huadong Peng 3 , Sreejith Jayasree Varma 4 , Lucia Herrera-Dominguez 1 4 , Markus Ralser 5 6 7 8 , Rodrigo Ledesma-Amaro 9"
Publicado en: Nature Chemical Biology, 2023, ISSN 1552-4469
Editor: Nature
DOI: 10.1038/s41589-023-01341-2

What makes Yarrowia lipolytica well suited for industry?

Autores: Young-KyoungPark, RodrigoLedesma-Amaro
Publicado en: Trends in Biotechnology, Edición 18793096, 2022, ISSN 1879-3096
Editor: Cell Press
DOI: 10.1016/j.tibtech.2022.07.006

A primer to directed evolution: current methodologies and future directions

Autores: Lara Sellés Vidal, Mark Isalan, John T. Heap, Rodrigo Ledesma-Amaro
Publicado en: RSC Chemical Biology, Edición 4, 2024, Página(s) 271-291, ISSN 2633-0679
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2cb00231k

Investigating the Potential of Division of Labor in Synthetic Bacterial Communities for the Production of Violacein

Autores: Harman Mehta, Jose Jimenez, Rodrigo Ledesma-Amaro, Guy-Bart Stan
Publicado en: ACS Synthetic Biology, Edición 14, 2025, Página(s) 2703-2709, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.5c00120

Synthetic biology and bioelectrochemical tools for electrogenetic system engineering

Autores: Joshua M. Lawrence, et al [...]Rodrigo Ledesma-Amaro
Publicado en: Science Advances, Edición 23752548, 2022, ISSN 2375-2548
Editor: Sciences Advanced
DOI: 10.1126/sciadv.abm5091