Understanding principles of neuroblastoma genome remodelling
Recent studies have revealed that cancer cells have the intrinsic ability to create and re-incorporate extrachromosomal circular DNAs. It has been shown that these genomic events are more frequent in primary human neuroblastomas, a childhood tumour, suggesting that DNA circularisation is a major driver of neuroblastoma genome remodelling. The EU-funded CancerCirculome aims to discover new principles of neuroblastoma genome remodelling, investigating the underlying mechanisms and functional consequences of extrachromosomal DNA circularisation and chromosomal re-integration. The uncovered principles will be applied to identify novel diagnostic and predictive markers for clinical risk assessment and neuroblastoma treatment.
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