Skip to main content

Circular DNA-driven cancer genome remodeling

Project description

Understanding principles of neuroblastoma genome remodelling

Recent studies have revealed that cancer cells have the intrinsic ability to create and re-incorporate extrachromosomal circular DNAs. It has been shown that these genomic events are more frequent in primary human neuroblastomas, a childhood tumour, suggesting that DNA circularisation is a major driver of neuroblastoma genome remodelling. The EU-funded CancerCirculome aims to discover new principles of neuroblastoma genome remodelling, investigating the underlying mechanisms and functional consequences of extrachromosomal DNA circularisation and chromosomal re-integration. The uncovered principles will be applied to identify novel diagnostic and predictive markers for clinical risk assessment and neuroblastoma treatment.

Call for proposal

ERC-2020-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 498 888

Beneficiaries (1)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 1 498 888
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments