Circular DNA-driven cancer genome remodeling

Project Information

CancerCirculome

Grant agreement ID: 949172

DOI 10.3030/949172

EC signature date 8 December 2020

Start date 1 February 2021

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 498 888,00

EU contribution € 1 498 888,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

Publications

Peer reviewed articles (6)

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Author(s): Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E.
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38747-4

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma

Author(s): Heathcliff Dorado García; Fabian Pusch; Yi Bei; Jennifer von Stebut; Glorymar Ibáñez; Kristina Guillan; Koshi Imami; Dennis Gürgen; Jana Rolff; Konstantin Helmsauer; Stephanie Meyer-Liesener; Natalie Timme; Victor Bardinet; Rocío Chamorro González; Ian C. MacArthur; Celine Y. Chen; Joachim Schulz; Antje M. Wengner; Christian Furth; Birgit Lala; Angelika Eggert; Georg Seifert; Patrick Hundsoe
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32023-7

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

Author(s): Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwar
Published in: Nature Genetics, 2023, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01386-y

The evolutionary dynamics of extrachromosomal DNA in human cancers

Author(s): Joshua T. Lange, John C. Rose, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Sabine Taschner-Mandl, Marie Bernkopf, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel
Published in: Nature Genetics, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01177-x

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH

Author(s): King L. Hung, Jens Luebeck, Siavash R. Dehkordi, Caterina I. Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H. Lomeli, Natasha E. Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E. Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G. Henssen, Julie A. Law, William J. Greenleaf, Roger S. Lo
Published in: Nature Genetics, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01190-0

ecDNA hubs drive cooperative intermolecular oncogene expression

Author(s): King L. Hung, Kathryn E. Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T. Lange, Rocío Chamorro González, Natasha E. Weiser, Celine Chen, Maria E. Valieva, Ivy Tsz-Lo Wong, Sihan Wu, Siavash R. Dehkordi, Connor V. Duffy, Katerina Kraft, Jun Tang, Julia A. Belk, John C. Rose, M. Ryan Corces, Jeffrey M. Granja, Rui Li, Utkrisht Rajkumar, Jordan Frie
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04116-8