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The evolutionary epidemiology of commensal bacteria: the case of Escherichia coli from 1980 to 2025

Project description

Improving our understanding of the evolutionary dynamics of pathogens

Understanding the rapid adaptation mechanisms of infectious pathogens is key to designing better management strategies. However, existing models often fail to explain these dynamics as the evolutionary processes causing these changes are largely unknown. The EU-funded EvoComBac project aims to address this challenge of evolutionary biology in the bacterial species Escherichia coli. To that end, it will develop a prospective cohort of 200 longitudinally followed healthy volunteers – the largest of its kind – and collect data to analyse and describe the ecology of Escherichia coli from within-host to population level. Ultimately, the project's work will lead to better predictions of evolutionary dynamics and better management policies for infectious pathogens.

Call for proposal

ERC-2020-STG
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Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Other
EU contribution
€ 1 070 018

Beneficiaries (2)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 070 018
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 429 875
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations