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Communications at the Synapse - a Near Atomic Resolution View into Cell-Cell Communication in the CNS

Project description

Taking a closer look at how cells 'talk' to each other

Cell-adhesion molecules (CAMs) play an important role in structuring the synaptic architecture through multifaceted interactions with a variety of synaptic partners and orchestrating neuronal communication. The EU-funded CellCellEM project will shed light on the mechanism governing CAMs' synaptic activities. Specifically, the project will combine single particle cryo-electron microscopy (cryo-EM), tomography and biochemical methodologies to dissect the molecular mechanisms of Latrophilins (LPHNs) – CAMs that mediate cell-cell communication at the synapse. The studies will aim at providing the structural basis for CAMs' function and will fully characterise the set of LPHN interactions with proteins at the central nervous system (CNS). The findings of the project will further enrich our knowledge of cell-cell communication in the CNS.

Host institution

WEIZMANN INSTITUTE OF SCIENCE
Net EU contribution
€ 1 499 885,00
Address
Herzl Street 234
7610001 Rehovot
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 1 499 885,00
Address
Herzl Street 234
7610001 Rehovot

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00