Project description
Taking a closer look at how cells 'talk' to each other
Cell-adhesion molecules (CAMs) play an important role in structuring the synaptic architecture through multifaceted interactions with a variety of synaptic partners and orchestrating neuronal communication. The EU-funded CellCellEM project will shed light on the mechanism governing CAMs' synaptic activities. Specifically, the project will combine single particle cryo-electron microscopy (cryo-EM), tomography and biochemical methodologies to dissect the molecular mechanisms of Latrophilins (LPHNs) – CAMs that mediate cell-cell communication at the synapse. The studies will aim at providing the structural basis for CAMs' function and will fully characterise the set of LPHN interactions with proteins at the central nervous system (CNS). The findings of the project will further enrich our knowledge of cell-cell communication in the CNS.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting Grant
Host institution
7610001 Rehovot
Israel
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Beneficiaries (1)
7610001 Rehovot
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