The hardships for life to become big – rethinking hypoxia as an evolutionary driver for the rise of complex multicellularity

Project Information

ParadOX

Grant agreement ID: 949538

DOI

10.3030/949538

EC signature date 8 September 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

LUNDS UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Sustained increases in atmospheric oxygen and marine productivity in the Neoproterozoic and Palaeozoic eras

Author(s): Richard G. Stockey, Devon B. Cole, Una C. Farrell, Heda Agić, Thomas H. Boag, Jochen J. Brocks, Don E. Canfield, Meng Cheng, Peter W. Crockford, Huan Cui, Tais W. Dahl, Lucas Del Mouro, Keith Dewing, Stephen Q. Dornbos, Joseph F. Emmings, Robert R. Gaines, Timothy M. Gibson, Benjamin C. Gill, Geoffrey J. Gilleaudeau, Karin Goldberg, Romain Guilbaud, Galen Halverson, Emma U. Hammarlund, Kalev Hant
Published in: Nature Geoscience, Issue 17, 2024, Page(s) 667-674, ISSN 1752-0894
Publisher: Nature Publishing Group
DOI: 10.1038/s41561-024-01479-1

Rapid marine oxygen variability: Driver of the Late Ordovician mass extinction

Author(s): Nevin P Kozik, Seth A Young, Sean M Newby, Mu Liu, Daizhao Chen, Emma U Hammarlund, David PG Bond, Theodore R Them, Jeremy D Owens
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abn8345

“Hypoxic” Silurian oceans suggest early animals thrived in a low-O2 world

Author(s): Emma R. Haxen, Niels H. Schovsbo, Arne T. Nielsen, Sylvain Richoz, David K. Loydell, Nicole R. Posth, Donald E. Canfield, Emma U. Hammarlund
Published in: Earth and Planetary Science Letters, Issue 622, 2024, Page(s) 118416, ISSN 0012-821X
Publisher: Elsevier BV
DOI: 10.1016/j.epsl.2023.118416

Origin and evolution of animal multicellularity in the light of phylogenomics and cancer genetics

Author(s): Florian Jacques, Etienne Baratchart, Kenneth J. Pienta & Emma U. Hammarlund
Published in: Medical Oncology, 2022, ISSN 1357-0560
Publisher: Humana Press, Inc.
DOI: 10.1007/s12032-022-01740-w

Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation

Author(s): Christopher Carroll, Auraya Manaprasertsak, Arthur Boffelli Castro, Hilda van den Bos, Diana C.J. Spierings, René Wardenaar, Anuraag Bukkuri, Niklas Engström, Etienne Baratchart, Minjun Yang, Andrea Biloglav, Charlie K. Cornwallis, Bertil Johansson, Catharina Hagerling, Marie Arsenian-Henriksson, Kajsa Paulsson, Sarah R. Amend, Sofie Mohlin, Floris Foijer, Alan McIntyre, Kenneth J. Pienta, Emma
Published in: Cancer Research Communications, Issue 4, 2024, Page(s) 691-705, ISSN 2767-9764
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/2767-9764.crc-23-0396

Sulfidic anoxia in the oceans during the Late Ordovician mass extinctions – insights from molybdenum and uranium isotopic global redox proxies

Author(s): Tais W.Dahl, Emma U.Hammarlund, Christian Mac Ørum Rasmussen, David P.G.Bond, Donald E.Canfield
Published in: Earth-Science Reviews, 2021, ISSN 0012-8252
Publisher: Elsevier BV
DOI: 10.1016/j.earscirev.2021.103748

The sedimentary geochemistry and paleoenvironments project

Author(s): Úna C Farrell, Rifaat Samawi, Savitha Anjanappa, Roman Klykov, Oyeleye O Adeboye, Heda Agic, Anne‐Sofie C Ahm, Thomas H Boag, Fred Bowyer, Jochen J Brocks, Tessa N Brunoir, Donald E Canfield, Xiaoyan Chen, Meng Cheng, Matthew O Clarkson, Devon B Cole, David R Cordie, Peter W Crockford, Huan Cui, Tais W Dahl, Lucas D Mouro, Keith Dewing, Stephen Q Dornbos, Nadja Drabon, Julie A Dumoulin, Joseph
Published in: Geobiology, 2021, ISSN 1472-4669
Publisher: Wiley-Blackwell
DOI: 10.1111/gbi.12462

Early Silurian δ13Corg excursions in the foreland basin of Baltica, both familiar and surprising

Author(s): Emma U. Hammarlund, David K. Loydell, Arne T. Nielsen, Niels H. Schovsbo
Published in: Palaeogeography, Palaeoclimatology, Palaeoecology, Issue 526, 2023, Page(s) 126-135, ISSN 0031-0182
Publisher: Elsevier BV
DOI: 10.1016/j.palaeo.2019.03.035

Hypoxia inducible factor‐2α importance for migration, proliferation, and self‐renewal of trunk neural crest cells

Author(s): Camilla U. Niklasson, Elina Fredlund, Emanuela Monni, Jessica M. Lindvall, Zaal Kokaia, Emma U. Hammarlund, Marianne E. Bronner, Sofie Mohlin
Published in: Developmental Dynamics, 2021, ISSN 1058-8388
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dvdy.253

Benthic diel oxygen variability and stress as potential drivers for animal diversification in the Neoproterozoic-Palaeozoic

Author(s): Emma U. Hammarlund, Anuraag Bukkuri, Magnus D. Norling, Mazharul Islam, Nicole R. Posth, Etienne Baratchart, Christopher Carroll, Sarah R. Amend, Robert A. Gatenby, Kenneth J. Pienta, Joel S. Brown, Shanan E. Peters, Kasper Hancke
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-57345-0

Tackling ongoing crises with collective evolutionary knowledge

Author(s): Emma U. Hammarlund, Liselotte Jauffred, Nicole R. Posth, Karina K. Sand
Published in: Evolving Earth, Issue 2, 2024, Page(s) 100043, ISSN 2950-1172
Publisher: Elsevier BV
DOI: 10.1016/j.eve.2024.100043

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

Author(s): Emma U. Hammarlund, Emily Flashman, Sofie Mohlin, Francesco Licausi
Published in: Science, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aba3512

On the Origin of Information Dynamics in Early Life

Author(s): Robert A. Gatenby, Jill Gallaher, Hemachander Subramanian, Emma U. Hammarlund, Christopher J. Whelan
Published in: Life, Issue 15, 2025, Page(s) 234, ISSN 2075-1729
Publisher: MDPI AG
DOI: 10.3390/life15020234

Hypoxia Generated by Avian Embryo Growth Induces the HIF-α Response and Critical Vascularization

Author(s): Christopher Carroll, Niklas Engström, Patrik F. Nilsson, Emma R. Haxen, Sofie Mohlin, Peter Berg, Ronnie N. Glud and Emma U. Hammarlund
Published in: Frontiers in Ecology and Evolution, 2021, ISSN 2296-701X
Publisher: Frontiers in Ecology and Evolution
DOI: 10.3389/fevo.2021.675800

Roadmap to the study of gene and protein phylogeny and evolution—A practical guide

Author(s): Florian Jacques, Paulina Bolivar, Kristian Pietras, Emma U Hammarlund
Published in: Plos One, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0279597

The contribution of evolvability to the <scp>eco‐evolutionary</scp> dynamics of competing species

Author(s): Anuraag Bukkuri, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Emma U. Hammarlund, Joel S. Brown
Published in: Ecology and Evolution, Issue 13, 2023, ISSN 2045-7758
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/ece3.10591

Development of Iron Speciation Reference Materials for Palaeoredox Analysis

Author(s): Lewis J. Alcott, Alexander J. Krause, Emma U. Hammarlund, Christian J. Bjerrum, Florian Scholz, Yijun Xiong, Andrew J. Hobson, Lesley Neve, Benjamin J. W. Mills, Christian März, Bernhard Schnetger, Andrey Bekker, Simon W. Poulton
Published in: Geostandards and Geoanalytical Research, Issue 44, 2023, Page(s) 581-591, ISSN 1639-4488
Publisher: Association Scientifique pour la Geologie et ses Applications
DOI: 10.1111/ggr.12342

Redox dynamics of later Cambrian oceans

Author(s): Benjamin C. Gill, Tais W. Dahl, Emma U. Hammarlund, Matthew A. LeRoy, Gwyneth W. Gordon, Donald E. Canfield, Ariel D. Anbar, Timothy W. Lyons
Published in: Palaeogeography, Palaeoclimatology, Palaeoecology, 2021, ISSN 0031-0182
Publisher: Elsevier BV
DOI: 10.1016/j.palaeo.2021.110623

A life history model of the ecological and evolutionary dynamics of polyaneuploid cancer cells

Author(s): Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend & Joel S. Brown
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-18137-4