Theranostic Immune Cell

Project Information

theranoimmuno

Grant agreement ID: 950101

DOI

10.3030/950101

Project closed

EC signature date 19 February 2021

Start date 1 March 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 480 982,00

EU contribution

€ 1 480 982,00

Coordinated by

CENTRE DE LUTTE CONTRE LE CANCER CENTRE PAUL STRAUSS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Supramolecular Heterodimer Peptides Assembly for Nanoparticles Functionalization

Author(s): Clélia Mathieu, Shayamita Ghosh, Julien Draussin, Adeline Gasser, Guillaume Jacquot, Mainak Banerjee, Tanushree Gupta, Marc Schmutz, Céline Mirjolet, Olivier Tillement, François Lux, Andrey S. Klymchenko, Mariel Donzeau, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe
Published in: Advanced Healthcare Materials, 2024, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202304250

Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology

Author(s): Guillaume Jacquot, Pedro Lopez Navarro, Coralie Grange, Lotfi Boudali, Sébastien Harlepp, Xavier Pivot, Alexandre Detappe
Published in: Advanced Materials, Issue 36, 2025, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202406604

Engineering the subcutaneous delivery of antibody-drug conjugates

Author(s): Alexandre Detappe, María Gutiérrez-Blanco, Xavier Pivot
Published in: Journal of Controlled Release, Issue 395, 2026, Page(s) 114941, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2026.114941

Spacer engineering in nanoparticle–peptide conjugates boosts targeting specificity for tumor-associated antigens

Author(s): María de los Angeles Ramírez, Jolie Bou-Gharios, Barbara Freis, Julien Draussin, Clémence Cheignon, Loic J. Charbonnière, Sophie Laurent, Thomas Gevart, Adeline Gasser, Sebastian Jung, Fabien Rossetti, Olivier Tillement, Georges Noel, Xavier Pivot, Alexandre Detappe, Sylvie Bégin-Colin, Sébastien Harlepp
Published in: Nanoscale, Issue 17, 2026, Page(s) 5021-5032, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4nr02931c

Optimal Physicochemical Properties of Antibody–Nanoparticle Conjugates for Improved Tumor Targeting

Author(s): Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonnière, Xavier Pivot, Alexandre Detappe
Published in: Advanced Materials, 2022, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202110305

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects

Author(s): Marie-Charlotte Diringer, Pierre Coliat, Clélia Mathieu, Nina Laurent, Carole Mura, Mainak Banerjee, Chen Zhu, Anna Grabowska, Alison Ritchie, Philip Clarke, Alexandre Bernard, Claire Vit, Hélène Burckel, Georges Noel, Peter Harvey, Xavier Pivot, Alexandre Detappe
Published in: Small, 2023, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202205961

Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies

Author(s): Thomas Gréa, Guillaume Jacquot, Arthur Durand, Clélia Mathieu, Adeline Gasser, Chen Zhu, Mainak Banerjee, Elyse Hucteau, Joris Mallard, Pedro Lopez Navarro, Bogdan V. Popescu, Eloise Thomas, David Kryza, Jacqueline Sidi‐Boumedine, Giuseppe Ferrauto, Eliana Gianolio, Guillaume Fleith, Jérôme Combet, Susana Brun, Stéphane Erb, Sarah Cianferani, Loïc J. Charbonnière, Lyne Fellmann, Céline M
Published in: Advanced Materials, Issue 36, 2025, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308738

Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells

Author(s): Vincent Mittelheisser, Olivier Lefebvre, Mainak Banerjee, Shayamita Ghosh, Amandine Dupas, Marie‐Charlotte Diringer, Juliette Blumberger, Louis Bochler, Sébastien Harlepp, Annabel Larnicol, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Chloé Moritz, Christine Carapito, Raphaël Carapito, Loïc J. Charbonnière, François Lux, Olivier Tillement, Jacky G. Goetz, Alexandre Detappe
Published in: Advanced Science, Issue 12, 2026, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202505729

Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies

Author(s): Thomas Gréa; Guillaume Jacquot; Arthur Durand; Clélia Mathieu; Adeline Gasser; Chen Zhu; Mainak Banerjee; Elyse Hucteau; Joris Mallard; Pedro Lopez Navarro; Bogdan V. Popescu; Eloise Thomas; David Kryza; Jacqueline Sidi‐Boumedine; Giuseppe Ferrauto; Eliana Gianolio; Guillaume Fleith; Jérôme Combet; Susana Brun; Stéphane Erb; Sarah Cianferani; Loïc J. Charbonnière; Lyne Fellmann; Céline M
Published in: Advanced Materials, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308738

A Modular Supramolecular Peptide Platform Reveals Atomic-Number-Dependent Mechanisms Driving Radioenhancement

Author(s): Sebastian Jung, Pedro Lopez Navarro, Elsa Barbé, Adeline Gasser, Jolie Bou-Gharios, Mariel Donzeau, Céline Mirjolet, Georges Noel, Jean-Louis Schmitt, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe
Published in: ACS Nano, Issue 19, 2025, Page(s) 40394-40403, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.5c09326

Functionalization of chitosan with a polycarboxylic macrocycle yields injectable hydrogel with pH and salts responsiveness

Author(s): Arthur Durand, Thomas Gréa, Gabin Lebeau, Guillaume Jacquot, Augustin Tillement, Axel Aigle, Eloïse Thomas, David Kryza, Jacqueline Taleb, Giuseppe Ferrauto, Eliana Gianolio, Alain Géloën, Alexandra Montembault, Maria Gutiérrez-Blanco, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe, Laurent David, François Lux, Olivier Tillement
Published in: Materials Today Advances, Issue 25, 2025, Page(s) 100565, ISSN 2590-0498
Publisher: Elsevier BV
DOI: 10.1016/j.mtadv.2025.100565

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Author(s): Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe
Published in: Advanced Materials, Issue 38, 2026, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.74387

Anti-BCMA Immuno-nanoPET Radiotracers for Improved Detection of Multiple Myeloma

Author(s): Eloise Thomas; Clélia Mathieu; Patricia Moreno-Gaona; Vincent Mittelheisser; François Lux; François Lux; Olivier Tillement; Xavier Pivot; P. Peter Ghoroghchian; P. Peter Ghoroghchian; Alexandre Detappe
Published in: Advanced Healthcare Materials, 2021, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202101565

Non-peer reviewed articles (1)

Dynamic precision cancer nanomedicine

Author(s): Alexandre Detappe, Fabrice André
Published in: Nature Reviews Bioengineering, Issue 4, 2026, Page(s) 9-10, ISSN 2731-6092
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44222-025-00392-5