Theranostic Immune Cell

Informazioni relative al progetto

theranoimmuno

ID dell’accordo di sovvenzione: 950101

DOI

10.3030/950101

Progetto chiuso

Data della firma CE 19 Febbraio 2021

Data di avvio 1 Marzo 2021

Data di completamento 31 Agosto 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 480 982,00

Contributo UE

€ 1 480 982,00

Coordinato da

CENTRE DE LUTTE CONTRE LE CANCER CENTRE PAUL STRAUSS
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (13)

Supramolecular Heterodimer Peptides Assembly for Nanoparticles Functionalization

Autori: Clélia Mathieu, Shayamita Ghosh, Julien Draussin, Adeline Gasser, Guillaume Jacquot, Mainak Banerjee, Tanushree Gupta, Marc Schmutz, Céline Mirjolet, Olivier Tillement, François Lux, Andrey S. Klymchenko, Mariel Donzeau, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202304250

Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology

Autori: Guillaume Jacquot, Pedro Lopez Navarro, Coralie Grange, Lotfi Boudali, Sébastien Harlepp, Xavier Pivot, Alexandre Detappe
Pubblicato in: Advanced Materials, Numero 36, 2025, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202406604

Engineering the subcutaneous delivery of antibody-drug conjugates

Autori: Alexandre Detappe, María Gutiérrez-Blanco, Xavier Pivot
Pubblicato in: Journal of Controlled Release, Numero 395, 2026, Pagina/e 114941, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2026.114941

Spacer engineering in nanoparticle–peptide conjugates boosts targeting specificity for tumor-associated antigens

Autori: María de los Angeles Ramírez, Jolie Bou-Gharios, Barbara Freis, Julien Draussin, Clémence Cheignon, Loic J. Charbonnière, Sophie Laurent, Thomas Gevart, Adeline Gasser, Sebastian Jung, Fabien Rossetti, Olivier Tillement, Georges Noel, Xavier Pivot, Alexandre Detappe, Sylvie Bégin-Colin, Sébastien Harlepp
Pubblicato in: Nanoscale, Numero 17, 2026, Pagina/e 5021-5032, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/d4nr02931c

Optimal Physicochemical Properties of Antibody–Nanoparticle Conjugates for Improved Tumor Targeting

Autori: Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonnière, Xavier Pivot, Alexandre Detappe
Pubblicato in: Advanced Materials, 2022, ISSN 1521-4095
Editore: Wiley
DOI: 10.1002/adma.202110305

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects

Autori: Marie-Charlotte Diringer, Pierre Coliat, Clélia Mathieu, Nina Laurent, Carole Mura, Mainak Banerjee, Chen Zhu, Anna Grabowska, Alison Ritchie, Philip Clarke, Alexandre Bernard, Claire Vit, Hélène Burckel, Georges Noel, Peter Harvey, Xavier Pivot, Alexandre Detappe
Pubblicato in: Small, 2023, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202205961

Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies

Autori: Thomas Gréa, Guillaume Jacquot, Arthur Durand, Clélia Mathieu, Adeline Gasser, Chen Zhu, Mainak Banerjee, Elyse Hucteau, Joris Mallard, Pedro Lopez Navarro, Bogdan V. Popescu, Eloise Thomas, David Kryza, Jacqueline Sidi‐Boumedine, Giuseppe Ferrauto, Eliana Gianolio, Guillaume Fleith, Jérôme Combet, Susana Brun, Stéphane Erb, Sarah Cianferani, Loïc J. Charbonnière, Lyne Fellmann, Céline M
Pubblicato in: Advanced Materials, Numero 36, 2025, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308738

Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells

Autori: Vincent Mittelheisser, Olivier Lefebvre, Mainak Banerjee, Shayamita Ghosh, Amandine Dupas, Marie‐Charlotte Diringer, Juliette Blumberger, Louis Bochler, Sébastien Harlepp, Annabel Larnicol, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Chloé Moritz, Christine Carapito, Raphaël Carapito, Loïc J. Charbonnière, François Lux, Olivier Tillement, Jacky G. Goetz, Alexandre Detappe
Pubblicato in: Advanced Science, Numero 12, 2026, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202505729

Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies

Autori: Thomas Gréa; Guillaume Jacquot; Arthur Durand; Clélia Mathieu; Adeline Gasser; Chen Zhu; Mainak Banerjee; Elyse Hucteau; Joris Mallard; Pedro Lopez Navarro; Bogdan V. Popescu; Eloise Thomas; David Kryza; Jacqueline Sidi‐Boumedine; Giuseppe Ferrauto; Eliana Gianolio; Guillaume Fleith; Jérôme Combet; Susana Brun; Stéphane Erb; Sarah Cianferani; Loïc J. Charbonnière; Lyne Fellmann; Céline M
Pubblicato in: Advanced Materials, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308738

A Modular Supramolecular Peptide Platform Reveals Atomic-Number-Dependent Mechanisms Driving Radioenhancement

Autori: Sebastian Jung, Pedro Lopez Navarro, Elsa Barbé, Adeline Gasser, Jolie Bou-Gharios, Mariel Donzeau, Céline Mirjolet, Georges Noel, Jean-Louis Schmitt, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe
Pubblicato in: ACS Nano, Numero 19, 2025, Pagina/e 40394-40403, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.5c09326

Functionalization of chitosan with a polycarboxylic macrocycle yields injectable hydrogel with pH and salts responsiveness

Autori: Arthur Durand, Thomas Gréa, Gabin Lebeau, Guillaume Jacquot, Augustin Tillement, Axel Aigle, Eloïse Thomas, David Kryza, Jacqueline Taleb, Giuseppe Ferrauto, Eliana Gianolio, Alain Géloën, Alexandra Montembault, Maria Gutiérrez-Blanco, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe, Laurent David, François Lux, Olivier Tillement
Pubblicato in: Materials Today Advances, Numero 25, 2025, Pagina/e 100565, ISSN 2590-0498
Editore: Elsevier BV
DOI: 10.1016/j.mtadv.2025.100565

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Autori: Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe
Pubblicato in: Advanced Materials, Numero 38, 2026, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.74387

Anti-BCMA Immuno-nanoPET Radiotracers for Improved Detection of Multiple Myeloma

Autori: Eloise Thomas; Clélia Mathieu; Patricia Moreno-Gaona; Vincent Mittelheisser; François Lux; François Lux; Olivier Tillement; Xavier Pivot; P. Peter Ghoroghchian; P. Peter Ghoroghchian; Alexandre Detappe
Pubblicato in: Advanced Healthcare Materials, 2021, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202101565

Non-peer reviewed articles (1)

Dynamic precision cancer nanomedicine

Autori: Alexandre Detappe, Fabrice André
Pubblicato in: Nature Reviews Bioengineering, Numero 4, 2026, Pagina/e 9-10, ISSN 2731-6092
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44222-025-00392-5