In-situ spatiotemporal imaging of membrane hydration, electrostatics, tension and curvature to understand cell response to osmotic shocks and cell migration.

Información del proyecto

R2-TENSION

Identificador del acuerdo de subvención: 951324

DOI

10.3030/951324

Fecha de la firma de la CE 14 Enero 2021

Fecha de inicio 1 Noviembre 2021

Fecha de finalización 31 Octubre 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 4 947 465,00

Aportación de la UE

€ 4 947 465,00

Coordinado por

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

Ion-Induced Transient Potential Fluctuations Facilitate Pore Formation and Cation Transport through Lipid Membranes.

Autores: David Roesel; Maksim Eremchev; Chetan S. Poojari; Jochen S. Hub; Sylvie Roke
Publicado en: J. Am. Chem. Soc., Edición 1, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.48550/arxiv.2207.10963

HydroFlipper membrane tension probes: imaging membrane hydration and mechanical compression simultaneously in living cells

Autores: José García-Calvo; Javier López-Andarias; Jimmy Maillard; Vincent Mercier; Chloé Roffay; Aurélien Roux; Alexandre Fürstenberg; Naomi Sakai; Stefan Matile
Publicado en: Chemical science, Edición 1, 2022, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sc05208j

Passive coupling of membrane tension and cell volume during active response of cells to osmosis

Autores: Chloé Roffay, Guillaume Molinard, Kyoohyun Kim, Marta Urbanska, Virginia Andrade, Victoria Barbarasa, Paulina Nowak, Vincent Mercier, José García-Calvo, Stefan Matile, Robbie Loewith, Arnaud Echard, Jochen Guck, Martin Lenz, Aurélien Roux
Publicado en: Proceedings of the National Academy of Sciences, 2021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2103228118

Sum-Frequency Scattering Spectroscopy Reveals the Charging Mechanism and Surface Structure of hBN Nanoflakes in Solution

Autores: Benjamin Rehl, Nathan Ronceray, Li Zhang, Aleksandra Radenovic, Sylvie Roke
Publicado en: ACS Nano, Edición 19, 2025, Página(s) 24912-24919, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.5c03589

Integer topological defects organize stresses driving tissue morphogenesis

Autores: Pau Guillamat, Carles Blanch-Mercader, Guillaume Pernollet, Karsten Kruse, Aurélien Roux
Publicado en: Nature Materials, 2022, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-022-01194-5

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

Autores: O. B. Tarun, N. Dupertuis, David. M. Wilkins, S. Roke
Publicado en: The Journal of Physical Chemistry B, Edición 129, 2025, Página(s) 8798-8805, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.5c03073

Passive transport of Ca2+ ions through lipid bilayers imaged by wide-field second harmonic microscopy

Autores: M. Eremchev; D. Roesel; C. S. Poojari; A. Roux; J. S. Hub; S. Roke
Publicado en: Biophys. J., 2023, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2023.01.018

Epithelial cells adapt to curvature induction via transient active osmotic swelling

Autores: Caterina Tomba, Valeriy Luchnikov, Luca Barberi, Carles Blanch-Mercader, Aurélien Roux
Publicado en: Developmental Cell, 2022, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2022.04.017

Membrane potential fluctuations and water asymmetry on plasma cell and model lipid membranes: origins, implications and properties

Autores: Zhi Li, Iwona Swiderska, Lena Dalifoski, Seonwoo Lee, Nelson Alonso Correa-Rojas, David Roesel, Maksim Eremchev, Mischa Flor, Orly B. Tarun, Arianna Marchioro, Sylvie Roke
Publicado en: Faraday Discussions, Edición 259, 2025, Página(s) 342-365, ISSN 1359-6640
Editor: Royal Society of Chemistry
DOI: 10.1039/d4fd00197d

Interfacial Inversion, Interference, and IR Absorption in Vibrational Sum Frequency Scattering Experiments

Autores: S. Pullanchery, L. Zhang, S. Kulik, and S. Roke
Publicado en: Journal Of Physical Chemistry B, 2023, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.3c02727

Water as a contrast agent to quantify surface chemistry and physics using second harmonic scattering and imaging: A perspective

Autores: D. Roesel, M. Eremchev, T. Schönfeldová, S. Lee, S. Roke
Publicado en: Appl. Phys. Lett., 2022, ISSN 0003-6951
Editor: American Institute of Physics
DOI: 10.1063/5.0085807

Dissecting the membrane association mechanism of aerolysin pore at femtomolar concentrations using water as a probe

Autores: T. Roesel, C. Cao, JF. Bada Juarez, M. Dal Peraro, S. Roke
Publicado en: Nano Letters, 2024, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1101/2024.01.18.576179

Liposomes and Lipid Droplets Display a Reversal of Charge-Induced Hydration Asymmetry

Autores: Saranya Pullanchery, Nathan Dupertuis, Tereza Roesel, Sylvie Roke
Publicado en: Nano Letters, 2023, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.3c02653

Finite Volume Effects in Water Nanodroplets: A Molecular Level Investigation

Autores: Li Zhang, Saranya Pullanchery, Paul S. Cremer, Sylvie Roke
Publicado en: ACS Nano, Edición 19, 2025, Página(s) 23829-23839, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.5c04422

Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes

Autores: S. Lee, C. S. Poojari, A. Maznichenko, D. Roesel, I. Swiderska, P. Pohl, J. S. Hub, S. Roke
Publicado en: Journal of the American Chemical Society, 2024, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1021/jacs.4c02810

High throughput wide field second harmonic imaging of giant unilamellar vesicles

Autores: M. Eremchev, D. Roesel, P.-M. Dansette, A. Michailovas, S. Roke
Publicado en: Biointerphases, 2023, ISSN 1559-4106
Editor: American Vacuum Society
DOI: 10.1116/6.0002640

Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair

Autores: Souvik Naskar, Andrea Merino, Javier Espadas, Jayanti Singh, Aurelien Roux, Adai Colom, Harry H. Low
Publicado en: Nature Structural & Molecular Biology, 2024, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-024-01401-8

Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement

Autores: Morphogenesis requires spatiotemporal regulation of proliferation, both by biochemical and mechanical cues. In epithelia, this regulation is called contact inhibition of proliferation, but disentangling biochemical from mechanical cues remains challenging. Here, we show that epithelia growing under confinement accumulate pressure that inhibits proliferation above a threshold value. During growth,
Publicado en: Cell Reports, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111227

Interfacial Self-Assembly of Sugars at Nanoscale Membranes Leads to Micron-Scale, Spectroscopically Ice-Like Chiral Suprastructures of Water

Autores: Li Zhang, Jinchan Liu, Kislon Voïtchovsky, Chaudhary E. Rani, Saranya Pullanchery, Jan Dedic, Victor S. Batista, Georg E. Fantner, Sylvie Roke
Publicado en: Journal of the American Chemical Society, Edición 147, 2025, Página(s) 33413-33423, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.5c05215

Thesis and dissertations (2)

Correlated vibrational spectroscopy: A new window into molecular interactions

Autores: Mischa FLÓR
Publicado en: 2025
Editor: Ecole Polytechnique Fédérale Lausanne - EPFL

Droplets inside out: Molecular level studies of water at nanoscale aqueous interfaces

Autores: Li Zhang
Publicado en: 2025
Editor: Ecole Polythechnique fédérale Lausanne - EPFL