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Unraveling the complexity of fungal drug tolerance at multiple scales of biology

Project description

Shedding light on the mechanisms of antifungal drug tolerance

Despite the use of antifungal drugs, invasive fungal infections can lead to mortality in nearly 50 % of cases. Treatment failure may be a result of drug tolerance, which, is incompletely understood. The scope of the EU-funded FungalTolerance project is to reach a fundamental understanding of this type of tolerance. Researchers will carry out genomic and proteomic analysis of more than 1 000 fungal isolates and identify the biological mechanisms that drive drug tolerance in them. Moreover, they will screen candidate compounds that suppress tolerance and pave the way for novel, more effective antifungal strategies.

Host institution

TEL AVIV UNIVERSITY
Net EU contribution
€ 4 281 250,00
Address
Ramat Aviv
69978 Tel Aviv
Israel

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (3)

TEL AVIV UNIVERSITY
Israel
Net EU contribution
€ 4 281 250,00
Non-EU contribution
€ 0,00
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 4 989 668,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 420 000,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00